Nevilast Baby Tablet

Brand Name Nevilast Baby Tablet
Salt Composition

Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)

Strength 150mg + 30mg + 200mg
Product Form Tablet
Pack 30 Tablet(s) in strip
Storage Store below 30°C
Category

HIV

SubCategory

HIV

Country of Origin India
Manufacturer

Hetero Healthcare Ltd

Manufacturer/Marketer Address Hetero Healthcare Ltd, S.no: 80-84, Melange towers, PatrikaNagar,Madhapur,Hyderabad. Telangana-500081.
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M.R.P : Rs.210.00       Price : Rs.178.50

You Save : Rs.31.50    Inclusive of all taxes

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30 Tablet(s) in strip

Availability : In Stock


    Medical Description of Nevilast Baby Tablet

    Nevilast Baby tablet contains Lamivudine 150mg, stavudine 30mg and nevirapine 200mg. Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection. Nevilast Baby tablet is a nucleoside analogue. Nevilast Baby tablet works by reducing the viral load of HIV in your body. Nevilast Baby tablet improves your immune system and reduces the risk of conditions associated with HIV infection.


    Nevilast Baby Tablet Uses

    Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is used to treat adults and adolescence >50 kgs of weight or >12 years of age who are infected by HIV-1. Caution is used in cases of liver and renal impairment.


    Nevilast Baby Tablet Benefits

    Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is used with other anti-HIV medication to help control HIV infection. Nevilast Baby tablet helps to decrease the amount of HIV in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Nevilast Baby tablet is a nucleoside analogue. Nevilast Baby tablet is not a cure for HIV infection, it improves immunity that results in longevity of life. It is not recommended for use in children less than 12 years of age or less than 50 kgs of weight due to the increased risk of serious side effects.


    Nevilast Baby Tablet Indication

    Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is indicated in the treatment of HIV-1 infection that causes AIDS in humans. Nevilast Baby tablet is used to boost the immunity of the affected hosts. Nevilast Baby tablet is indicated in ages above 12 years of age who weigh more than 50 Kgs.


    Mechanism of action of Nevilast Baby Tablet

    Nevilast Baby tablet contains Lamivudine 150mg, stavudine 30mg and nevirapine 200mg. Lamivudine is HIV-1 nucleoside reverse transcriptase inhibitor. Lamivudine is phosphorylated to its active forms lamivudine triphosphate that is incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Stavudine is a nucleoside reverse transcriptase inhibitor that is phosphorylated into stavudine -5- triphosphate. Stavudine-5-triphosphate battle with deoxythymidine triphosphate and incorporate themselves into the DNA of HIV molecular structure. After they incorporate within the DNA of HIV molecule the further process such as transcription, reverse transcriptase enzyme is inhibited. Nevirapine is a non-nucleoside reverse transcriptase inhibitor that binds to reverse transcriptase of HIV-1 particle thus blocks RNA and DNA dependant DNA polymerase actions that is required for replication of HIV-1. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.


    How Nevilast Baby Tablet works

    Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Nevilast Baby tablet inhibits the action of HIV-1 reverse transcriptase enzyme by incorporating themselves into the nucleotide sequence thus inhibits the action of the reverse transcriptase of HIV-1, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection and improves immunity.


    Nevilast Baby Tablet Contraindication

    Absolute contraindication:

    • if you are allergic to Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet and its contents
    • if you are pregnant
    • if you are breastfeeding
    • children <12 years of age.

    Relative contraindication:

    • if you have a liver disorder like hepatitis B or C or Child-Pugh disease
    • if you have neurologic disorders
    • if you have pancreatitis
    • if you have renal diseases or filtration impairment


    Nevilast Baby Tablet Side Effects

    Very common side effects that occur in more than 1:10 patients: rash

    Common side effects that occur 1:10 patients: Headache, Cough, nausea, vomiting, abdominal pain, diarrhea, alopecia, Arthralgia, Myalgia, Fatigue, malaise, fever, Back pain. Neutropenia, Thrombocytopenia, increase in AST, ALT bilirubin levels, granulocytopenia, hepatitis

    Uncommon side effects that occur 1:100 patients: anemia, Insomnia, Anxiety, Depression, Pancreatitis, Peripheral neuropathy, difficulty breathing, anaphylactic shock, jaundice, Stevens-Johnson Syndrome/toxic epidermal necrolysis, urticaria, angioedema, arthralgia, myalgia, decreased blood phosphorus, increased blood pressure

    Rare side effects that occur 1:1000 patients: Pure red cell aplasia, Lactic acidosis, Pancreatitis, elevations in serum amylase, Angioedema, Rhabdomyolysis, cardiomyopathy, convulsions, lipodystrophy, lactic acidosis, fulminant hepatitis, drug reaction with eosinophilia, decrease in skin sensations


    FAQs for Nevilast Baby Tablet

    Is Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet safe during pregnancy?

    No, taking Nevilast Baby tablet during is not recommended. Consult your physician.

    Can Nevilast Baby tablet be taken while breastfeeding?

    No, in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding.

    Can Nevilast Baby tablet be taken while alcohol consumption?

    The interaction is unknown but this medication causes neurological side effects. Thus, consult your physician.

    Can I take drive or operate heavy machineries while on Nevilast Baby tablet?

    This medication causes neurological side effects thus caution is used while driving or operating machineries.

    What is the most common side effect of Nevilast Baby tablet?

    Nevilast Baby tablet causes rash (skin manifestation) and jaundice (systemic manifestation)


    Precautions and general warning of Nevilast Baby Tablet

    Alcohol

    Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution as Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet causes side effects. For further queries, consult your physician.

    Pregnancy

    The use of Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is not recommended during pregnancy. It causes serious fatal toxicity and fetal death.

    Breast Feeding

    The use of Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effects in newborn.

    Kidney Problem

    Renal filtration impairment – monitor function of creatinine clearance rate before and during treatment. caution is used in case creatinine clearance is <50ml/min.

    Liver Disease

    Liver disorders and diseases like hepatitis B or C, hepatic steatosis

    Monitor liver function like AST, ALT and bilirubin levels before and during therapy


    How to Take Nevilast Baby Tablet

    Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is taken orally without food.

    Nevilast Baby tablet must be taken at the same time every day as prescribed by your physician.

    After therapy has been initiated, do not take more or less of Nevilast Baby medicine than prescribed or stop taking it without your physicians’ approval. Skipping or changing Nevilast Baby tablet dose without approval may cause the amount of the virus to increase making the infection more difficult to treat, or worsen side effects.


    Use of Nevilast Baby Tablet in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.

    The recommended age for the use of Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is >18 years who are >60 kgs

    Follow the instructions provided above.


    Use of Nevilast Baby Tablet in children

    The recommended age for the use of Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet  is >12 years who are >50 kgs

    The lead-in period for Nevilast Baby tablet to build tolerance is 14 days.

    The recommended dosage is one tablet of Nevilast Baby tablet taken once a day followed by an oral dose of Lamivudine 150mg and Stavudine 30mg after 12 hours.

    After the lead-in period the tolerance is checked (skin rash occurrence/ liver and kidney/ blood workup) the recommended maintenance dosage for Nevilast Baby tablet taken twice a day orally

    Nevilast Baby tablet should be taken as prescribed by the physician without fail. These medicines must be taken without food on a regular time basis either 2 hours before food or 2 hours after food intake


    Use of Nevilast Baby Tablet in Elderly Patients

    Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Pancreatitis
    • Accumulation or Redistribution of body fat or
    • immune reconstitution syndrome.
    • Any sign of infection – fever or lymph node enlargement


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have a kidney problem

    If you have a blood disorder

    If you are pregnant or breastfeeding


    General instructions

    Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is taken with other antivirals orally as prescribed dosage at a specific time regularly.


    Drug Interaction of Nevilast Baby Tablet

    Drug-Drug Interaction

    Serum concentration decreased by Acetazolamide, Potassium citrate

    Serum concentration increased by Aceclofenac, Acetaminophen, Ketoconazole, Itraconazole

    Severity of adverse effects is increased by Acyclovir, Dopamine, Histamine, Metformin

    Drug-Food Interaction

    Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. It is best to take Nevilast Baby tablet on an empty stomach either 2 hrs before or after food. Nevilast Baby tablet generally causes side effects thus it is advised not to be taken with alcohol.

    Drug-Disease Interaction

    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
    • Pancreases disorders – used with caution in pancreatitis. Consult a physician before use


    Over Dose

    Contact your doctor, pharmacist or nurse immediately.


    Missed Dose

    If you take twice a day dosage, then the missed dosage if you notice within 6 hours. If it is more than 6 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 30°C


    Fast Tag

    Nevilast Baby (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is a nucleoside analogue.

    Nevilast Baby tablet is used to control and treat HIV infection with other antivirals

    Do not use this medication while pregnant or lactation period.

    Don’t use this medication with liver disease and kidney diseases.

    This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury, etc.