Nevivir 200mg Tablet
Brand Name | Nevivir 200mg Tablet |
Salt Composition |
Nevirapine (200mg) |
Strength | 200mg |
Product Form | Tablet |
Pack | 60 Tablet(s) in 1 Bottle |
Storage | Store below 30°C |
Category |
HIV |
SubCategory |
HIV |
Country of Origin | India |
Manufacturer |
Hetero Healthcare Ltd |
Manufacturer/Marketer Address | Hetero Healthcare Ltd, S.no: 80-84, Melange towers, PatrikaNagar,Madhapur,Hyderabad. Telangana-500081. |
You Save : Rs.293.49 Inclusive of all taxes
- if you are allergic to Nevivir (Nevirapine (200mg)) tablet or its contents
- use of Nevivir tablet as a prophylactic to exposure in occupational diseases
- if you have severe liver problems like Child-Pugh class B or C or hepatic impairment
- if you are breastfeeding
- if you have kidney disease
- if you are diabetic
- if you have bleeding disorder like haemophilia
- if you have heart diseases
- Increase in weight
- Increase in glucose levels
- Increase in lipid levels
- Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
- Accumulation or Redistribution of body fat or immune reconstitution syndrome.
- Granulocytopenia
- Liver disorders – used with caution in severe liver diseases. Consult physician before use
- Kidney disorders – used with caution in severe kidney diseases. Consult physician before use
- Cardiac disorders – used with caution in heart failure and MI. Consult physician before use
- Respiratory disorders – used with caution in respiratory distress. Consult physician before use
Medical Description of Nevivir 200mg Tablet
Nevivir tablet contains Nevirapine 200mg. Nevivir (Nevirapine (200mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV)-1 infection. Nevivir tablet is a non-nucleoside reverse transcriptase inhibitor. Nevirapine works by acting on reverse transcriptase which is required for HIV active particles multiplication process thus reduces viral load of HIV in your body. Nevivir tablet is used in combination with other antiviral HIV medications.
Nevivir 200mg Tablet Uses
Nevivir (Nevirapine (200mg)) tablet is an antiviral belonging to the family of non-nucleoside reverse transcriptase inhibitor which is used to treat HIV – 1 infection in paediatric and adults. Nevivir tablet is also used in treating pregnant women since it prevents maternal-fetal HIV transmission who have not taken any other antivirals before. Nevivir tablet must be taken in combination with a low dose of other anti-HIV medicines. Your doctor will discuss which combination of medicines is best for you.
Nevivir 200mg Tablet Benefits
Nevivir (Nevirapine (200mg)) tablet is used with other anti-HIV medication to help control HIV infection and maternal-fetal transmission of HIV. Nevivir tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Nevivir tablet is a non-nucleoside reverse transcriptase inhibitor. Nevivir tablet is not a cure for HIV infection, it improves immunity that results in longevity of life; thus, precautions are necessary while sexual intercourse, surgery etc.
Nevivir 200mg Tablet Indication
Nevivir (Nevirapine (200mg)) tablet is indicated in the treatment of HIV-1 infection that causes AIDS in humans. Nevivir tablet is also used in case of pregnancy as it reduces maternal-fetal transmission of active virions that causes HIV infection in new-born. Nevivir tablet is used with other antiviral medications to boost the immunity of the affected hosts by reducing the viral load of the infected cells.
Mechanism of action of Nevivir 200mg Tablet
Nevivir (Nevirapine (200mg)) tablet is a non-nucleoside reverse transcriptase inhibitor that binds to reverse transcriptase of HIV-1 particle thus blocks RNA and DNA dependant DNA polymerase actions that are required for replication of HIV-1. Bioavailability of Nevirapine is >90%. Nevirapine can cross placenta, CSF, and breast milk.
How Nevivir 200mg Tablet works
Nevivir (Nevirapine (200mg)) tablet is a non-nucleoside reverse transcriptase inhibitor. Nevirapine binds to reverse transcriptase and blocks DNA polymerase-dependent actions on RNA and DNA. Thus, Nevirapine causes disruption in the enzyme catalyse site of HIV-1 particles which is required for the replication of HIV-1. Nevirapine decreases the viral load and increases CD4+ T cell count thus promotes immunity in HIV-infected patients.
Nevivir 200mg Tablet Contraindication
Absolute contraindication:
Relative contraindications:
Nevivir 200mg Tablet Side Effects
Very common side effect that occurs in more than 1:10 patients: rash
Common side effects that occur 1:10 patients: granulocytopenia, hypersensitivity, headache, nausea, vomiting, abdominal pain, diarrhoea, hepatitis, fatigue, fever.
Uncommon side effects that occur 1:100 patients: swelling of the face, difficulty breathing, anaphylactic shock, anaemia, jaundice, Stevens Johnson Syndrome/toxic epidermal necrolysis, urticaria, angioedema, arthralgia, myalgia, decreased blood phosphorus, increased blood pressure
Rare side effects that occur 1:1000 patients: fulminant hepatitis, drug reaction with eosinophilia and systemic symptoms, decreased numbers of red blood cells or platelets, inflammation of the pancreas, decrease in skin sensations
FAQs for Nevivir 200mg Tablet
Is Nevivir (Nevirapine (200mg)) tablet safe during pregnancy?
This medication can be taken safely during pregnancy unless pros outweigh the cons. Consult your physician.
Can Nevivir tablet be taken while breastfeeding?
There is no specific study to detail this. But in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding. Thus, consult your physician.
Can Nevivir tablet be taken while alcohol consumption?
The interaction is unknown. Thus, consult your physician.
Can I take Nevivir tablet alone?
No, Nevivir tablet should be used with other antivirals for the treatment.
Can I take Nevivir tablet as a precaution for exposure?
No, Nevivir tablet should not be taken as a precaution to exposure. Kindly consult your physician.
Precautions and general warning of Nevivir 200mg Tablet
Alcohol
Nevivir (Nevirapine (200mg)) tablet generally causes fatigue thus it is advised not to be taken with alcohol. For further queries, consult your physician.
Driving or operating machinery
It is preferred to drive or operate heavy machinery with caution as Nevivir (Nevirapine (200mg)) tablet causes fatigue. For further queries, consult your physician.
Pregnancy
The use of Nevivir (Nevirapine (200mg)) tablet causes no fetal toxicity or any malformation in the uterine. If CD4+ cells are>250/mm3 the incidence rate of hepatotoxicity is increased, thus caution is used.
Breast Feeding
Nevivir (Nevirapine (200mg)) tablet crosses the placenta and breast milk thus it is not advised to breastfeed while on this medicine. for queries consult your physician.
Kidney Problem
Consult your physician
Liver Disease
Caution is advised in case of hepatitis B or C or Child Purg disease
Nevivir (Nevirapine (200mg)) tablet causes severe and fatal fulminant hepatitis. The risk is higher during the first 6 weeks of treatment thus close monitoring is advised. It causes abnormal liver function values like elevation of GGT thus close monitoring is advised and after 2 months of treatment monitoring with blood work for signs of jaundice is advised every 2 weeks and after 3 months of treatment monthly blood work is advised.
How to Take Nevivir 200mg Tablet
Nevivir (Nevirapine (200mg)) tablet should not be taken alone and must be combined with at least 2 other antivirals.
Nevivir tablet is taken orally with food.
Swallow Nevivir tablet as a whole.
Don’t crush, break or chew Nevivir tablet.
After therapy has been initiated, do not take more or less of Nevivir than prescribed or stop taking it without your physicians’ approval. Skipping or changing Nevivir tablet dose without approval would increase the viral load making the infection more difficult to treat, or worsen side effects. For further queries consult your physician.
Use of Nevivir 200mg Tablet in Adult
Nevivir (Nevirapine (200mg)) tablet is taken once a day for 14 days which is called as ‘lead in period’ until tolerance is developed and then 400mg prolonged-release tablets once a day is recommended.
Use of Nevivir 200mg Tablet in children
The recommended dosage is Nevivir (Nevirapine (200mg)) tablet taken once a day for 14 days if no rash occurs it is followed by 200mg twice per day
Use of Nevivir 200mg Tablet in Elderly Patients
Nevivir (Nevirapine (200mg)) tablet has only been used in few patients 60 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.
Other general warnings
Talk to your doctor if
If you have any allergy
If you have a liver problem
If you have any bleeding problem
If you are pregnant or breastfeeding
General instructions
Nevivir (Nevirapine (200mg)) tablet is taken with other antivirals orally as prescribed dosage at a specific time regularly with food. If It is taken separately or without food, the efficiency of the medicine is reduced significantly, thus it is ill-advised.
Drug Interaction of Nevivir 200mg Tablet
Drug-Drug Interaction
Decrease in metabolism by Clarithromycin, Amiodarone, Diltiazem
Increase in metabolism by Methadone, verapamil
Increase in serum concentration by Fluconazole, Ketoconazole, Itraconazole
Severity of side effect increased by Acetylcholine, Ganciclovir, Dopamine, Histamine, Metformin
Drug-Food Interaction
Nevivir (Nevirapine (200mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. It generally causes fatigue thus it is advised not to be taken with alcohol.
Drug-Disease Interaction
Over Dose
There is no clear studies thus contact your doctor immediately.
Missed Dose
You can take the missed dosage if you notice within 8 hours. Always take with ritonavir and food. If it is more than 8 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.
Storage and Disposal
Keep the medication out of children’s reach
Keep the medication away from pets
Once expired dispose immediately
There are no special conditions for storage
Fast Tag
Nevivir (Nevirapine (200mg)) tablet is a non-nucleoside reverse transcriptase inhibitor.
Nevivir tablet can be safely used in pregnancy
Don’t use this medication with liver disease or if you develop a rash
This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury, etc.