Nintenib 100mg Capsule

Brand Name Nintenib 100mg Capsule
Salt Composition

Nintedanib (100mg)

Strength 100mg
Product Form Soft Gelatin Capsule
Pack 10 Capsule(s) in Strip
Storage Store below 30°C
Category

Antifibrotic

SubCategory

Idiopathic Pulmonary Fibrosis

Country of Origin India
Manufacturer

BDR Pharmaceuticals Internationals Pvt

Manufacturer/Marketer Address BDR Pharmaceuticals Internationals Pvt, 407-408, Sharda Chambers, New Marine Lines, Mumbai 400 020 (Maharashtra), New Marine Lines, Marine Lines, Mumbai, Maharashtra 400020
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Nintenib 100mg Capsule, Nintedanib 100mg, Price, Uses, Side effects - Drugcarts watermark
M.R.P : Rs.750.00       Price : Rs.622.50

You Save : Rs.127.50    Inclusive of all taxes

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10 Capsule(s) in Strip

Availability : In Stock

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    Medical Description of Nintenib 100mg Capsule

    Nintenib 100mg Capsule contains Nintedanib 100mg it is a tyrosine kinase inhibitor. Nintedanib inhibits metastasis, angiogenesis and oncogenesis of abnormal cancer cells and used in the treatment of lung disease like fibrosis and cancers. This medication is recommended only for adults.


    Nintenib 100mg Capsule Uses

    This capsule is used in treatment of lung cancer, Idopathic pulmonary fibrosis (IPF) and interstitial lung disease. It is not used in children. 


    Nintenib 100mg Capsule Benefits

    Nintenib 100mg Capsule inhibits the progression of abnormal cells. It is used in treatment of non-small cell lung cancer, idiopathic pulmonary fibrosis (IPF) and interstitial lung disease. This capsule is recommended only in adults.


    Nintenib 100mg Capsule Indication

    Nintedanib is a tyrosine kinase inhibitor. It is an antineoplastic and antiangiogenic medication. It inhibits the multiplication or proliferation of abnormal cells by inhibiting endothelial growth factors. It must be used only in adults. This medication is recommended in the treatment of non-small cell lung cancer which is locally advanced or metastatic or recurrent caused by adenocarcinoma. It is used in the treatment of idiopathic pulmonary fibrosis with slowly decreasing pulmonary function. This capsule is used in the case of systemic sclerosis-associated interstitial lung disease with a decrease in pulmonary function.


    Mechanism of action of Nintenib 100mg Capsule

    Nintenib 100mg (Nintedanib 100mg) Capsule is an antineoplastic and an antiangiogenic agent. It is a tyrosine kinase inhibitor. It inhibits receptor tyrosine kinase and non-receptor tyrosine kinase. Receptor tyrosine kinase inhibits platelet-derived growth factor, fibroblast growth factor receptor, vascular endothelial growth factor receptor. It binds to ATP location in receptor thus blocks signalling activity that causes proliferation and migration of lung fibroblasts thus inhibits proliferation and induces apoptosis. Nintenib 100mg Capsule also inhibits non-receptor tyrosine kinase that inhibits the SRC pathway thus reduces fibrosis in the lungs and improves the function of the lungs


    How Nintenib 100mg Capsule works

    This capsule is an antineoplastic, an antineoplastic and a tyrosine kinase inhibitor. It inhibits tyrosine kinase and non-tyrosine kinase receptors thus inhibit vasculature and decrease migration of fibroblasts. It inhibits proliferation and induces apoptosis improving the function of the lungs.


    Nintenib 100mg Capsule Contraindication

    • if you are allergic to Nintenib 100mg (Nintedanib 100mg) Capsule or its constituents
    • if you have a liver disorder
    • if you are pregnant
    • if you are breastfeeding


    Nintenib 100mg Capsule Side Effects

    • Diarrhea
    • Nausea
    • Abdominal pain
    • Elevated liver enzymes
    • Vomiting
    • Decreased appetite
    • Skin ulcer
    • Bleeding events
    • Headache
    • Hypertension
    • Arterial thromboembolic events
    • Myocardial infarction
    • Bronchitis
    • Hypothyroidism
    • Pneumonia
    • Lung neoplasm malignant
    • Gastrointestinal perforation
    • Pancreatitis
    • Thrombocytopenia
    • Drug-induced liver injury
    • Pruritus
    • Alopecia


    FAQs for Nintenib 100mg Capsule

    • Is Nintenib 100mg (Nintedanib 100mg) Capsule safe during pregnancy?

    No, taking this medication during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

    • Can Nintenib 100mg Capsule be taken while breast feeding?

    No, in general, it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that this medication can also pass via breastfeeding.

    • Can Nintenib 100mg Capsule be taken while alcohol consumption?

    The interaction is unknown but this medication causes side effects. Thus, consult your physician.

    • Can I take a drive or operate heavy machinery while on Nintenib 100mg Capsule?

    This medication causes side effects thus caution is used while driving or operating machinery.


    Precautions and general warning of Nintenib 100mg Capsule

    Alcohol

    Alcohol intake with this medication causes side effects thus caution is required. Consult your physician

    Driving or operating machinery

    Driving or operating heavy machinery with this medication causes side effects thus caution is required. Consult your physician.

    Pregnancy

    Nintedanib causes embryo-fetal toxicity

    Breast Feeding

    The infant who is breast fed shows cardiotoxic effects similar to adults

    Kidney Problem

    During Nintedanib therapy monitor creatinine clearance levels before and during treatment

    Liver Disease

    During the treatment with Nintedanib monitor liver function before and during treatment


    How to Take Nintenib 100mg Capsule

    Nintenib 100mg (Nintedanib 100mg) Capsule is taken orally. It must be taken at the same time as prescribed by your physician.

    This capsule should be taken with food.

    Don’t drink grape juice or eat grapes.

    It must be swallowed as a whole. Don’t open or crush this capsule.

    After therapy has been initiated, do not take more or less of this drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing your dose without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.


    Use of Nintenib 100mg Capsule in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.

    The recommended dosage in idiopathic pulmonary fibrosis is 100mg taken orally with food twice a day

    The recommended dosage in Systemic Sclerosis-associated Interstitial Lung Disease is 100mg taken orally with food twice a day

    Nintenib 100mg Capsule is used as an orphan drug in the case of mesothelioma

    Dosage modification is done in the case of hepatotoxicity or renal toxicity or GI toxicity or cardiotoxicity occurs.


    Use of Nintenib 100mg Capsule in children

    Nintenib 100mg Capsule is not recommended in children.


    Use of Nintenib 100mg Capsule in Elderly Patients

    Nintenib 100mg Capsule has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    Pulmonary toxicity – interstitial lung disease/pneumonitis

    Cardiotoxicity - Cardiac failure/left ventricular dysfunction/prolonged QT syndrome/bradycardia/electrolyte imbalance

    Arterial thromboembolic event – MI/stroke


    Talk to your doctor if

    • If you have any allergy
    • If you have a liver problem
    • If you have lung problem
    • If you are pregnant or breastfeeding


    General instructions

    Nintenib 100mg Capsule is taken orally as prescribed dosage at the specific time regularly with food to avoid adverse effects. Do not take grape juice or eat grapes with this medication. Do not take medications that alter the PH of the stomach like PPI, H2 blockers and if you are taking them, it is best to take them either 1 hr before or 2 hrs after intake of food.


    Drug Interaction of Nintenib 100mg Capsule

    Drug-Drug Interaction

    Metabolism is increased by Calcitriol, St. John's Wort and Vitamin E

    Serum level is increased by Folic acid

    Metabolism is decreased by Ginkgo biloba, Niacin

    Drug-Food Interaction

    Do not take grapes and grape juice while taking this medication. To avoid diarrhea, take small sips of sugar free drinks or take small amounts of meal or take spicy food with this medication. It should be taken either with food, if doubts arise kindly refer to your physician. It generally causes side effects thus it is advised not to be taken with alcohol. It is preferred to drive or operate heavy machinery with caution while taking this medication.

    Drug-Disease Interaction

    • Lung disorders – used with caution in interstitial lung disease. Consult a physician before use
    • Electrolyte disorders – used with caution in electrolyte imbalance. Consult a physician before use
    • Bone disorders – used with caution in hypocalcemia and hypopotassemia. Consult a physician before use
    • Cardiac disorders – used with caution in hypotension or hypertension and heart failure. Consult a physician before use
    • Haematological disorders – used with caution in bleeding disorders like thrombosis. Consult a physician before use
    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory depression. Consult a physician before use


    Over Dose

    Overdosage of Nintenib 100mg Capsule has less literature thus Contact your physician.


    Missed Dose

    You can take the missed dosage if you notice within 6 hours. If it is more than 6 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 30°C


    Fast Tag

    Nintenib 100mg Capsule is an antiangiogenic antineoplastic

    Nintedanib is a tyrosine kinase inhibitor

    It is used to control and treat fibrosis of the lung

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease or kidney disease