Pazonat 200mg Tablet
Brand Name | Pazonat 200mg Tablet |
Salt Composition |
Pazopanib (200mg) |
Strength | 200mg |
Product Form | Tablet |
Pack | 30 Tablet(s) in Bottle |
Storage | Store below 30°C |
Category |
Anti-Cancer |
SubCategory |
Kidney Cancer |
Country of Origin | India |
Manufacturer |
Natco Pharma Ltd |
Manufacturer/Marketer Address | Natco Pharma Ltd,Natco House, Road No:2, Banjara Hills, Hyderabad, (A.P ) 500 033 India |
You Save : Rs.1,300.00 Inclusive of all taxes
- Advanced renal cell carcinoma
- Advanced soft tissue sarcoma except for the adipocytic type
- Increased liver enzymes
- Diarrhea
- Hypertension
- Hair color changes
- Leukopenia
- Thrombocytopenia
- Decreased sodium level
- Vomiting
- Fatigue
- Abdominal pain
- Weight loss
- Hair loss
- Are there any food restrictions while I’m taking a Pazonat 200mg Tablet?
- Can I stop using the Pazonat 200mg Tablet immediately or do I have to slowly wean off the use?
- Does the Pazonat 200mg Tablet cause hair loss?
- Patients who are above 65 years are at higher risk for developing hepatotoxicity
- The use of this medicine may increase the liver enzymes ALT, AST, and Bilirubin
- Indirect hyperbilirubinemia may occur in patients with Gilbert’s syndrome
- Hemorrhage, fatal arterial thromboembolic events, and cerebral intracranial hemorrhage were reported
- Venous thromboembolic events including venous thrombosis and pulmonary embolus were reported
- Thrombotic microangiopathy, gastrointestinal perforation, and pneumonitis has been reported
- The use of this medicine may cause hypothyroidism, infection, and proteinuria
- Kindly avoid pregnancy because the use of this medicine may cause fetal harm
- Kindly avoid this medicine if you planned for surgery because the use of this medicine impair the wound healing
- You are not responding to the treatment
- You have experienced any allergic reaction like rashes and itching
- You have a receiving any concomitant medication and disease
- Stored at 10-30°C room temperature.
- Protect from light and heat.
- Keep away from children and pets. Otherwise, it becomes toxic to them.
- Disposed of properly in a suitable bag.
- Pazopanib 200mg is an anti-cancer medication, a tyrosine kinase inhibitor
- It is used to treat advanced renal cell carcinoma (kidney cancer) and soft tissue sarcomas.
- Closely monitor the patient kidney function and blood cell count while you are receiving this medicine
- Kindly inform your doctor if you have experienced headache, stomach pain, and blood in your stool and urine while you are receiving this medicine.
- Kindly use birth control to avoid pregnancy while you are receiving this medicine.
- The major side effect of this medicine is diarrhea, drink plenty of fluids to avoid dehydration
- Monitor blood pressure, thyroid function, and bleeding problem while you are receiving this medicine
Medical Description of Pazonat 200mg Tablet
Pazonat 200mg Tablet contains Pazopanib 200mg used to treat cancer that occurs in and around joints, muscles, tendons, blood vessels, and organs. It works by inhibiting the enzyme which is responsible for the growth and multiplication of cancer cells. It is not recommended for children.
Pazonat 200mg Tablet Uses
It is used in the treatment of the following conditions as advanced renal cell carcinoma (kidney cancer) and soft tissue sarcomas.
Pazonat 200mg Tablet Benefits
Advanced renal cell carcinoma
It is a common type of kidney cancer found in adults. It is caused by obesity, smoking cigarettes, polycystic kidney disease, and some genetic condition. Symptoms include blood in urine, loss of appetite, weight loss, tiredness, and fever.
Advanced soft tissue sarcomas
It is a type of cancer that usually develops in the soft tissue of your body that begins in the tissue that connects other body structures. Symptoms include swelling and lumps, and muscle pain.
Pazonat 200mg Tablet Indication
The Pazonat 200mg Tablet is prescribed in the following indications as
Mechanism of action of Pazonat 200mg Tablet
Pazonat 200mg Tablet contains Pazopanib 200mg is an anti-cancer medication, tyrosine kinase inhibitor. It produces its action by targeting several tyrosine kinase proteins which are present on the surface of VEGF receptors, PDGF receptor, FGF receptor, cytokine receptor called as kit, IL 2 receptor, lymphocyte tyrosine kinase receptor, transmembrane tyrosine kinase receptor. By inhibiting the function of the above-mentioned receptor, the growth of abnormal cells is inhibited.
How Pazonat 200mg Tablet works
Pazonat 200mg Tablet contains Pazopanib 200mg is an anti-cancer medication, tyrosine kinase inhibitor. It produces its action by inhibiting the function of tyrosine kinase protein which is present on receptors of vascular or platelet or lymphocyte etc. Thus, alters the function of receptors thereby inhibiting the proliferation and growth of abnormal cells.
Pazonat 200mg Tablet Contraindication
Do not take this medicine if you are allergic to Pazopanib
Pazonat 200mg Tablet Side Effects
FAQs for Pazonat 200mg Tablet
Yes, kindly avoid taking grapefruit and grapefruit juice while you are receiving this medicine because it may affect the effectiveness of this medicine.
You should not withdraw the medicine immediately, you should taper the dose to avoid rebound effects
Yes, one of the common side effects of this medicine is hair loss. Kindly consult with your doctor if your symptoms even persist after withdrawal of the medicines.
Precautions and general warning of Pazonat 200mg Tablet
Alcohol
It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.
Driving or operating machinery
It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive, decrease alertness, and make you feel sleepy and drowsy. Kindly consult with your doctor.
Pregnancy
The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor
Breast Feeding
The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor
Kidney Problem
It is considered safe to use this medicine in patients who are having a renal impairment. Kindly consult with your doctor.
Liver Disease
Therapy should be administered with caution in patients who are having hepatic impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.
How to Take Pazonat 200mg Tablet
Pazonat 200mg Tablet is to be taken on an empty stomach. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.
Use of Pazonat 200mg Tablet in Adult
It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor
Use of Pazonat 200mg Tablet in children
Safety and efficacy were not established in children who are below 18 years old. Kindly consult with your doctor.
Use of Pazonat 200mg Tablet in Elderly Patients
Pazonat 200mg Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.
Other general warnings
Talk to your doctor if
General instructions
Pazopanib 200mg is used to treat advanced renal cell carcinoma (kidney cancer) and soft tissue sarcomas. It produces its action by inhibiting the function of tyrosine kinase protein which is present on receptors of vascular or platelet or lymphocyte etc. Thus, alters the function of receptors thereby inhibiting the proliferation and growth of abnormal cells.
Drug Interaction of Pazonat 200mg Tablet
Drug-Drug Interaction
Aluminum hydroxide
It is contraindicated to use this medicine because the use of aluminum hydroxide will decrease the effect of pazopanib by increasing its gastric pH.
Deferiprone
Use alternative drug because the combination of this medicine either increases the toxicity of the other by pharmacodynamic synergism
Escitalopram
Use alternative drugs because the use of escitalopram increases the toxicity of the pazopanib by QTc interval
Apalutamide
Therapy should be administered with caution because the use of apalutamide will decrease the effect of pazopanib by increasing its elimination
Dexamethasone
Therapy should be administered with caution because the use of dexamethasone will decrease the effect of pazopanib by affecting its hepatic and intestinal enzyme metabolism
Dextromethorphan
Therapy should be administered with caution because the use of pazopanib increases the level of dextromethorphan by decreasing its metabolism.
Drug-Food Interaction
The use of grapefruit juice increases the blood level of Sunitinib and also increases the risk of side effects such as dizziness, confusion, hallucinations, mood changes, insomnia, drowsiness, congestive heart failure, and QT prolongation.
Drug-Disease Interaction
Bleeding
Kindly avoid this medicine if you have a history of hemoptysis and cerebral hemorrhage because the use of this medicine increases the risk of bleeding
Liver dysfunction
Therapy should be administered with caution because the use of this medicine may cause severe and fatal hepatotoxicity. No dosage adjustment is required in patients with mild hepatic impairment.
GI perforation
Kindly avoid this medicine in patients with ovarian cancer because the use of vascular endothelial growth factor receptors may cause GI perforation.
QT prolongation
Therapy should be administered with caution in patients with a history of QT interval prolongation because the use of this medicine may increase the risk of developing ventricular arrhythmias
Over Dose
Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.
Missed Dose
Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).
Storage and Disposal
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