Septran DS Tablet

Septran DS Tablet contains Sulfamethoxazole 800mg and Trimethoprim 160mg used to treat bacterial infections such as Bronchitis, Pneumonia, Toxoplasmosis, Nocardiosis, Urinary tract infections, Intraabdominal infections enteritis, Ear infections, Traveler’s diarrhea, Granuloma inguinale, and Chancroid. Mainly this bacterial infection targets the lungs (pneumonia, bronchitis), urinary tract, ear, and abdomen infection. Sulfamethoxazole, Trimethoprim is a Sulfonamide, Antibiotic that produces its action by preventing bacterial growth and helps to cure the infection. This medicine is not used for common flu and cold symptoms that occur due to viral infections. This medicine is commonly prescribed for cough and colds caused by bacterial infections.

It is used in the treatment of the following conditions as bacterial infections such as Bronchitis, Pneumonia, Toxoplasmosis, Nocardiosis, Urinary tract infections, Intraabdominal infections enteritis, Ear infections, Traveler’s diarrhea, Granuloma inguinale, and Chancroid

Bacterial infections

Bacterial infection occurs when bacteria enter your body and start multiplying which may cause tissue damage and make you sick. Mostly it is caused by Staphylococcus and Streptococcus organisms. The bacterial diseases are cholera, bacterial meningitis, tetanus, gonorrhea, pneumonia, and syphilis. Symptoms include fever, chills, and sweats, inflamed lymph nodes, headache, diarrhea, abdominal pain

Bronchitis

Infection of the swelling and irritation of bronchial tubes (air passage tubes in the lungs) called bronchitis caused by the bacteria. This medicine is used to treat this bacterial infection.

Pneumonia

Infection and inflammation to the respiratory air sacs of lungs called pneumonia caused by pneumocystis jiroveci bacteria. This medicine is used to treat this bacterial infection.

Toxoplasmosis

Infection caused by toxoplasma bacteria leads to develops muscle pain, fever and headache called toxoplasmosis. This medicine is used to treat this bacterial infection.

Nocardiosis

Infection to the lungs or whole body is caused by Nocardia bacteria called nocardiasis. This medicine is used to treat this bacterial infection.

Urinary tract infections

Infection to the urinary tract includes the kidneys, bladder, ureters, or urethra is called urinary tract infection caused by bacteria. Most common infection in humans. In some cases, this infection is caused by fungi or viruses. This medicine is used to treat this infection.

Intraabdominal infections enteritis

Infection and inflammation to the internal organs of the abdomen are caused by bacteria called Intraabdominal infection. This medicine is used to treat this bacterial infection.

Ear infections

Infection and inflammation to the ears caused by bacteria called ear infections include otitis media. This medicine is used to treat this bacterial infection.

Traveler’s diarrhea

Infection to the stomach and intestine caused by bacteria leads to abdominal cramps, bloating, and passage of loose stools, more than 3 or 4 times per day called traveler’s diarrhea. This medicine is used to treat this bacterial infection.

Granuloma inguinale

Infection to the anus and genital parts leads to damage to the affected parts caused by Klebsiella granulomatis called granuloma inguinale. This medicine is used to treat this bacterial infection,

Chancroid

It is a sexually transmitted infection caused by bacteria that develops painful genital ulcers. This medicine is used to treat this bacterial infection.

The Septran DS Tablet is prescribed in the following indications as Bronchitis, Pneumonia, Toxoplasmosis, Nocardiosis, Urinary tract infections, Intraabdominal infections enteritis, Ear infections, Traveler’s diarrhea, Granuloma inguinale, and Chancroid

Septran DS Tablet contains Sulfamethoxazole 800mg and Trimethoprim 160mg is a sulfonamide antibiotic that produces its action by inhibiting the production of folic acid which is a nutrient required for the bacteria for multiplication. The combination of this medicine effectively treats the infection.

Septran DS Tablet contains Sulfamethoxazole 800mg and Trimethoprim 160mg is a sulfonamide antibiotic that produces its action by inhibiting the production of folic acid which is a nutrient required for the bacteria for multiplication. The combination of this medicine effectively treats the infection.

• Do not take this medicine if you are allergic to Sulfamethoxazole and Trimethoprim
• It is contraindicated to use this medicine along with dofetilide
• The use of this medicine can cause megaloblastic or folate anemia
• It is contraindicated to use this medicine in patients who are having a history of drug-induced immune thrombocytopenia
• The use of this medicine may cause renal impairment

• Vertigo
• Seizure
• Peripheral neuritis
• Erythema multiforme
• Hyperkalemia
• Urticaria
• Stevens-Johnson syndrome
• Toxic epidermal necrolysis
• Agranulocytosis
• Hyponatremia
• Thrombocytopenia

• Is it safe to use Septran DS Tablet?

Yes, it is safe to use this medicine. But in some patients, the use of this medicine may cause uncommon side effects like nausea, vomiting, skin rash, allergic reaction. Kindly inform your doctor if your condition gets worsens.

• Can I stop taking Septran DS Tablet when my symptoms get relieved?

No, you should not stop taking this medicine until you finish full-course of treatment because it may worsen your condition

• What if I don’t get better after using this Septran DS Tablet?

Kindly inform your doctor if your symptoms don’t get better.

Alcohol

It is not clear that consuming alcohol may produce any harmful effect while you are receiving this medicine. Kindly consult with your doctor.

Driving or operating machinery

It is not clear that the use of this medicine may affect your ability to drive. Kindly consult with your doctor

Pregnancy

The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects on the fetus. Kindly consult with your doctor

Breast Feeding

The use of this medicine is considered safe during breastfeeding because it does not excrete via breast milk. Kindly consult with your doctor

Kidney Problem

The medicine should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

Liver Disease

The medicine should be used with caution in patients with hepatic impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

Septran DS Tablet is taken orally with food. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.

It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor.

It is considered unsafe to use this medicine in children who are below 2 years old. Kindly consult with your doctor.

Septran DS Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

• The use of this medicine can cause severe hyponatremia, acute or delayed lung injury
• The patients with a history of recent exposure to sulfamethoxazole-trimethoprim cause circulatory shock with fever, hypotension, and confusion
• Cough, shortness of breath, and pulmonary infiltrates are reported while you are using these medicines
• Therapy should be administered with caution in elderly people because it may increase the risk of developing bone marrow suppression
• At long-term, the use of this medicine may cause fungal or bacterial superinfection
• Therapy should be administered with caution in a patient who are having renal and hepatic impairment with folate deficiency
• The use of this medicine may cause Hemolysis in patients who are having G6PD deficiency
• When used along with leucovorin treatment failure and excess mortality were observed.

                 Diarrhea

• This medicine kills the good helpful bacteria in your stomach or intestine and causes diarrhea. It leads to worsening the patient’s health condition. Better to take probiotics with this medicine to avoid diarrhea.

                Antibiotic resistance

• Finish the complete course of antibiotics even if you feel better. Otherwise, it will lead to Antibiotic resistance (the bacteria may be resistant to antibiotics). After taking of complete course not feel better.

                  Porphyria

• It should be used with caution in patients with porphyria (group of disorders caused by excessive accumulation of porphyrin protein and it is linked to hemoglobin, which is essential for carrying oxygen supply in the blood), it leads to develops organ damage.

                 Hyperkalemia

• Using this medicine develops increased potassium levels in the blood leads to hyperkalemia. Monitor regularly potassium levels.

• You have a history of gastrointestinal disease
• You are not responding to the treatment
• You have experienced any allergic reaction like rashes and itching
• Do you have any concomitant diseases or receive any medication

Sulfamethoxazole 800mg and Trimethoprim 160mg is a sulfonamide antibiotic that produces its action by inhibiting the production of folic acid which is a nutrient required for the bacteria for multiplication. The combination of this medicine effectively treats the infection.

Drug-Drug Interaction

BCG vaccine live

The use of this medicine is contraindicated because the use of trimethoprim decreases the effect of the BCG vaccine live by pharmacodynamic antagonism

Abametapir

Use alternative drugs because the use of abametapir will increase the effect of trimetho[rim by affecting its hepatic and intestinal enzyme metabolism.

Amiodarone

Use alternative drug because the combination of this drug increases the QTc interval

Antithrombin 111

Use alternative drugs because the use of sulfamethoxazole increases the effect of antithrombin 111 by plasma protein binding competition.

Benazepril

Therapy should be administered with caution because the combination of this drug increases the serum potassium level and it also decreases the urinary potassium excretion

Cimetidine

Therapy should be administered with caution because the use of cimetidine increases the effect of sulfamethoxazole by basic drug competition for renal tubular clearance.

Drug-Food Interaction

Use of alcohol with sulfamethoxazole produces unpleasant side effects such as fast heartbeat, redness under your skin, tingly feeling, nausea, vomiting.

Drug-Disease Interaction

Colitis

This medicine kills the good helpful bacteria in your stomach or intestine and causes diarrhea. This drug should be used caution in patients with gastrointestinal disease, especially colitis (swelling of the colon inner lining). It leads to worsening the patient’s health condition.

Hematologic toxicity

Therapy should be administered with caution in patients who are having blood dyscrasias or bone marrow suppression because the use of sulfonamides may cause hematologic toxicity including methemoglobinemia, leucopenia, granulocytopenia, eosinophilia, hemolytic anemia, aplastic anemia, purpura, thrombocytopenia, and hypoprothrombinemia.

Liver diseases:

Therapy should be administered with caution  in patients with hepatic impairment because the use of sulfonamides may cause hepatotoxicity including jaundice, diffuse hepatocellular necrosis, hepatitis, and hepatic failure

Urinary obstruction

Therapy should be administered with caution in patients with urinary obstruction because the use of sulfonamides `increase the risk for developing renal toxicity such as uro and nephrolithiasis, nephritis, toxic nephrosis, hematuria, proteinuria, and elevated BUN and creatinine

Crystalluria

Using this medicine develops Crystalluria (precipitation of this drug occurs in the urinary tract), which leads to cloudy urine. Drink more liquids adequately to avoid this condition.

Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.

Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

• Stored at 10-30°C room temperature.
• Protect from light and heat.
• Keep away from children and pets. Otherwise, it becomes toxic to them.
• Disposed of properly in a suitable bag.

Septran DS Tablet contains Sulfamethoxazole 800mg and Trimethoprim 160mg used to treat bacterial infections such as Bronchitis, Pneumonia, Toxoplasmosis, Nocardiosis, Urinary tract infections, Intraabdominal infections enteritis, Ear infections, Traveler’s diarrhea, Granuloma inguinale, and Chancroid.

Sulfamethoxazole 800mg and Trimethoprim 160mg combination is a sulfonamide antibiotic used to treat bacterial infection by binding the folic acid nutrient (essential nutrient for bacterial multiplication) production. This drug combination together prevents infections effectively.

This medicine is not used for common flu and cold symptoms. And not treat viral infections. This medicine is commonly prescribed for cough and colds caused by bacterial and parasitic infections.

This medicine is contraindicated to allergic symptoms such as skin rash, itching, swelling and breathing difficulties, porphyria, and severe liver diseases.