Smaclif Plus Syrup

The Smaclif Plus Syrup contains Aceclofenac (50mg), and Paracetamol (125mg) used to reduce the body temperature, pain and inflammation in both infants and children. The combination of this medicine produces its action by inhibiting the release of chemical substances which cause pain and inflammation in your body.

It is used in the treatment of fever and as pain relief.

Pain relief

The use of this medicine helps to relieve moderate to severe pain in conditions like rheumatoid arthritis, osteoarthritis, muscle pain, back pain, and toothache by inhibiting the chemical messengers in the brain.

Fever

It is a temporary increase in your body temperature. It usually occurs in the area of your brain called the hypothalamus. Symptoms include sweating, chills, shivering, headache, muscle aches, loss of appetite, dehydration, and weakness.

The Smaclif Plus Syrup is prescribed in the following indications as a pain reliever and to reduce fever

Smaclif Plus Syrup contains Aceclofenac (50mg), and Paracetamol (125mg).Aceclofenac is an anti-inflammatory medication and Paracetamol is an antipyretic agent. The combination of this medicine produces its action by inhibiting the release of chemical messengers which is responsible for pain and inflammation

Smaclif Plus Syrup contains Aceclofenac (50mg), and Paracetamol (125mg).Aceclofenac is an anti-inflammatory medication and Paracetamol is an antipyretic agent. The combination of this medicine produces its action by inhibiting the release of chemical messengers which is responsible for pain and inflammation

• Do not take this medicine if you are allergic to Aceclofenac and Paracetamol
• It is contraindicated to use this medicine in patients with a history of asthma, urticaria, or coronary artery bypass graft surgery.
• It is contraindicated to use this medicine in patients with severe active liver disease.

• Edema
• Headache
• Dizziness
• Abdominal pain
• Constipation
• Diarrhea
• Flatulence
• Heartburn
• GI ulcers
• Abnormal renal function
• Elevated liver enzymes
• Hepatotoxicity
• Live failure
• Pneumonitis
• Nephrotoxicity

• Can I get my child vaccinated while on treatment with Smaclif Plus Syrup?

The use of antibiotics does not interfere with the ingredients in the vaccines. But as a preventive measure do not vaccinate your children until they recover from the illness.

• When will my child feel better?

Depending upon the severity of the infection the use of this medicine may take a few days to weeks to feel better.

• Can I increase or decrease the dose of Smaclif Plus Syrup for my child by myself according to the severity of the illness?

No, without consulting with your doctor you should not decrease or increase the dose because it may increase the toxicity or it may cause recurrence of symptoms.

Alcohol

Since it is used in children no information is available regarding the use of this medicine. Kindly consult with your doctor

Driving or operating machinery

Since it is used in children no information is available regarding the use of this medicine. Kindly consult with your doctor

Pregnancy

Since it is used in children no information is available regarding the use of this medicine. Kindly consult with the doctor

Breast Feeding

Since it is used in children no information is available regarding the use of this medicine. Kindly consult with the doctor

Kidney Problem

The medicine should be used with caution in patients with severe kidney impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

Liver Disease

The medicine should be used with caution in patients with severe liver impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

The Syrup is taken orally with or without food. Shake well before using this Syrup. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.

It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor.

It is considered safe to use this medicine in children. Kindly consult with your doctor.

Since it is used in children no information is available regarding the use of this medicine. Kindly consult with the doctor

•  Nonsteroidal anti-inflammatory drugs may increase the risk of developing cardiovascular thrombotic events, myocardial infarction, and stroke
• The use of this medicine also increases the risk of developing serious GI adverse events including bleeding, ulceration, and gastric perforation
• Therapy should be administered with caution in patients with bronchospasm, cardiac diseases, hepatic porphyria, hypertension, fluid retention, severe renal impairment, smoking, and systemic lupus erythematosus
• The use of this medicine decrease platelet aggregation and may prolong the bleeding time
• Therapy should be administered with caution in patients with blood dyscrasias, and bone marrow depression
• The use of this medicine may increase the risk of hyperkalemia and aseptic meningitis
• Therapy should be administered with caution in patients with severe hepatic impairment, renal impairment, chronic malnutrition, and G6PD deficiency.
• The use of this medicine increase the risk of developing hepatotoxicity, and serious skin reactions

• You have a history of gastrointestinal disease
• You are not responding to the treatment
• You have experienced any allergic reactions like rashes and itching
• You are suffering from anemia
• You have watery diarrhea, stomach pain, and fever

Aceclofenac (50mg), and Paracetamol (125mg) are used to reduce body temperature, pain, and inflammation in both infants and children. The combination of this medicine produces its action by inhibiting the release of chemical substances which cause pain and inflammation in your body.

Drug-Drug Interaction

Apixaban

The use of this drug is contraindicated because the combination of this drug increases the effect of anticoagulation

Captopril

Use alternative drug because the use of the non-steroidal anti-inflammatory drug may decrease the effectiveness of the antihypertensive drug and the combination of these drugs also decrease the renal functions

Aliskiren

Therapy should be administered with caution because the use of aceclofenac will decrease the effect of aliskiren on other

Apalutamide

Therapy should be administered with caution because the use of apalutamide will decrease the effect of acetaminophen by increasing its elimination.

Eltrombopog

Therapy should be administered with caution because the use of eltrombopag increases the levels of acetaminophen by decreasing its metabolism.

Isoniazid

Isoniazid will increase the effect of acetaminophen by affecting its hepatic enzyme metabolism. Therapy should be administered with caution.

Colestipol

Colestipol decreases the effect of acetaminophen by inhibiting GI absorption. Use alternative drugs.

Drug-Food Interaction

The use of alcohol should be avoided in patients who are taking this medicine because it may increase the risk of bleeding in the stomach which includes tarry, bloody stools, or coughing up blood while vomiting.Do not withdraw the medication without consulting with the doctor

Drug-Disease Interaction

Asthma

Therapy should be administered with caution in patients who are having asthma because the use of the non-steroidal anti-inflammatory drug (NSAIDs) in asthma patients may cause nasal polyposis, pansinusitis, eosinophilia, and rhinitis. Before initiating the therapy ask the patients whether they are allergic to salicylate salts.

Heart failure

Therapy should be administered with caution in patients with heart failure because the use of NSAIDs may cause fluid retention and edema

Hepatotoxicity

Therapy should be administered with caution in a patient with liver diseases because the use of NSAIDs may increase the serum transaminases, LDH, and alkaline phosphatase. And in rare cases, it may cause hepatotoxicity including liver cirrhosis, jaundice, and hepatic failure

Hypertension

Therapy should be administered with caution in patients with hypertension because the use of NSAIDs may increase blood pressure and cardiovascular events. During this course of treatment monitor the patient blood pressure

Renal toxicities

Therapy should be administered with caution in a patient with renal diseases because the use of NSAIDs may increase the serum creatinine, BUN, tubular necrosis, glomerulus, renal papillary necrosis, nephrotic syndrome, and cause renal failure.

Liver diseases

Therapy should be administered with caution in patients with hepatic insufficiency because severe liver injury including acute liver failure resulting in liver transplant and death has been reported in patients using acetaminophen. Patients with hepatic impairment may increase the risk of toxicity due to increased metabolic pathway activity. During acetaminophen-containing treatment, patients should avoid consuming alcohol.

Alcoholism

Therapy should be administered with caution in patients who are consuming alcohol because severe liver injury including acute liver failure resulting in liver transplant and death has been reported in patients using acetaminophen. During acetaminophen-containing treatment, patients should avoid consuming alcohol. The patient should immediately seek the hospital if they experience signs and symptoms of liver injury such as fever, rash, anorexia, nausea, vomiting, fatigue, dark urine, and jaundice.

Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose on this medicine immediately meet the doctor and rush to the nearby hospital.

Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

• Stored at 10-30°C room temperature.
• Protect from light and heat.
• Keep away from children and pets. Otherwise, it becomes toxic to them.
• Disposed of properly in a suitable bag.

• The Smaclif Plus Syrup contains Aceclofenac (50mg), and Paracetamol (125mg) used to reduce the body temperature, pain, and inflammation in both infants and children.
• The combination of this medicine produces its action by inhibiting the release of chemical substances which cause pain and inflammation in your body.
• Monitor the patient's kidney functions, liver function, and levels of blood components
• Avoid consuming alcohol because it may cause excessive drowsiness and stomach problems