Sorafenat 200mg Tablet

Brand Name Sorafenat 200mg Tablet
Salt Composition

Sorafenib (200mg)

Strength 200mg
Product Form Tablet
Pack 120 Tablet(s) in Bottle
Storage Store below 30°C
Category

Anti-Cancer

SubCategory

Kidney Cancer

Country of Origin India
Manufacturer

Natco Pharma Ltd

Manufacturer/Marketer Address Natco Pharma Ltd,Natco House, Road No:2, Banjara Hills, Hyderabad, (A.P ) 500 033 India
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M.R.P : Rs.8880.00       Price : Rs.7104.00

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120 Tablet(s) in Bottle

Availability : In Stock


    Medical Description of Sorafenat 200mg Tablet

    Sorafenat 200mg Tablet contains Sorafenib 200mg used to treat renal cell carcinoma (kidney cancer), Hepatocellular carcinoma (hepatic cancer), and Thyroid Cancer. It is not recommended in pediatric use


    Sorafenat 200mg Tablet Uses

    It is used in the treatment of the following conditions as renal cell carcinoma (kidney cancer), Hepatocellular carcinoma (hepatic cancer), and Thyroid cancer


    Sorafenat 200mg Tablet Benefits

    Renal cell carcinoma

    It is a common type of kidney cancer found in adults. It is caused by obesity, smoking cigarettes, polycystic kidney disease, and some genetic condition. Symptoms include blood in urine, loss of appetite, weight loss, tiredness, and fever.

    Hepatocellular carcinoma

    It is also called malignant hepatoma, it is a common type of liver cancer. It usually occurs in people who are having a chronic liver disease such as cirrhosis, hepatitis B or C. Symptoms include weight loss, inflamed liver, loss of appetite, stomach pain, and jaundice

    Thyroid cancer

    Abnormal cell growth in the thyroid gland leads to the formation of tumor and cause cancer. Symptoms include a lump on your neck, change in your voice, pain in your neck and throat, inflamed lymph nodes in your neck, and difficulty in swallowing.


    Sorafenat 200mg Tablet Indication

    The Sorafenat 200mg Tablet is prescribed in the following indications as

    • Unresectable hepatocellular carcinoma
    • Advanced renal cell carcinoma
    • Differentiated thyroid tumor – only when radioactive iodine treatment has failed


    Mechanism of action of Sorafenat 200mg Tablet

    Sorafenat 200mg Tablet contains Sorafenib 200mg is an anti-cancer medication, tyrosine kinase inhibitor. It produces its action by targeting several tyrosine kinase proteins present on surface receptors and intracellular structures of VEGF receptors, PDGF receptor, FGF receptor, cytokine receptor called as kit, IL 2 receptor, lymphocyte tyrosine kinase receptor, transmembrane tyrosine kinase receptor. In general, these receptors signal for angiogenesis and decrease apoptosis function. Sorafenib inhibits signals of angiogenesis and decreases the size of the tumor by starvation and increases apoptosis function.


    How Sorafenat 200mg Tablet works

    Sorafenat 200mg Tablet contains Sorafenib 200mg is an anti-cancer medication, tyrosine kinase inhibitor. It produces its action by inhibiting the function of tyrosine kinase protein present on receptors of vascular or platelet or lymphocyte etc. Thus, alters the function of receptors thereby inhibiting angiogenesis of abnormal cells and increasing apoptosis function thus proliferation of abnormal cells is inhibited.


    Sorafenat 200mg Tablet Contraindication

    • Do not take this medicine if you are allergic to Sorafenib
    • It is contraindicated to use this medicine in patients with squamous cell lung cancer along with carboplatin and paclitaxel


    Sorafenat 200mg Tablet Side Effects

    • Thrombocytopenia
    • Anemia
    • Rash
    • Diarrhea
    • Abdominal pain
    • Weight loss
    • Alopecia
    • Lymphopenia
    • Hypertension
    • Neuropathy
    • Dry skin


    FAQs for Sorafenat 200mg Tablet

    • I have developed redness and pain in my palms and soles ever since I started taking the Sorafenat 200mg Tablet and my skin is also coming off. Is this dangerous? What should I do?

    It looks like you have developed foot and hand skin reactions due to this medicine. Kindly consult with your doctor and apply cream or lotion to treat this issue.

    • Does Sorafenat 200mg Tablet interfere with blood sugar levels?

    Yes, the use of this medicine decreases the blood glucose level and makes the patients faint. Kindly monitor your blood sugar level regularly.

    • When can I plan a pregnancy if I am taking a Sorafenat 200mg Tablet?

    Avoid planning for pregnancy while you are receiving this medicine and also use an effective contraceptive for at least 1 month after taking the last medicine.


    Precautions and general warning of Sorafenat 200mg Tablet

    Alcohol

    It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

    Driving or operating machinery

    It is considered safe to drive while you are receiving this medicine it does not affect your ability to drive. Kindly consult with your doctor.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

    Breast Feeding

    The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

    Kidney Problem

    It is considered safe to use this medicine in patients who are having a renal impairment. Kindly consult with your doctor.

    Liver Disease

    Therapy should be administered with caution in patients who are having hepatic impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.


    How to Take Sorafenat 200mg Tablet

    Sorafenat 200mg Tablet is taken orally with food. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.


    Use of Sorafenat 200mg Tablet in Adult

    It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor


    Use of Sorafenat 200mg Tablet in children

    Safety and efficacy were not established in children who are below 18 years old. Kindly consult with your doctor.


    Use of Sorafenat 200mg Tablet in Elderly Patients

    Sorafenat 200mg Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • The use of this medicine may cause osteonecrosis of the jaw
    • The use of this medicine may increase the risk of developing cardiac ischemia, hypertension, and hemorrhage
    • Hepatitis, QT prolongation, Congestive heart failure, and Gastrointestinal perforation were reported while you are receiving this medicine
    • Avoid pregnancy
    • The use of this medicine has a high incidence for developing skin toxicity, rash, and bleeding


    Talk to your doctor if

    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You have a receiving any concomitant medication and disease


    General instructions

    Sorafenib 200mg is used to treat renal cell carcinoma (kidney cancer), Hepatocellular carcinoma (hepatic cancer), and Thyroid Cancer. It produces its action by inhibiting the function of tyrosine kinase protein present on receptors of vascular or platelet or lymphocyte etc. Thus, alters the function of receptors thereby inhibiting angiogenesis of abnormal cells and increasing apoptosis function thus proliferation of abnormal cells is inhibited.


    Drug Interaction of Sorafenat 200mg Tablet

    Drug-Drug Interaction

    Dronedarone

    It is contraindicated to use this medicine because the combination of this medicine increase the QTc interval

    Carbamazepine

    Use alternative drugs because the use of carbamazepine decreases the effect of sorafenib by increasing its metabolism.

    Ketoconazole

    Use alternative drugs because the use of ketoconazole increases the level of sorafenib by affecting its hepatic and intestinal enzyme metabolism.

    Dichlorphenamide

    Therapy should be administered with caution because the combination of this medicine may decrease the serum potassium

    Fingolimod

    Therapy should be administered with caution because the use of sorafenib increases the effect of fingolimod by immunosuppressive effect and it also increases the risk for developing infections.

    Drug-Food Interaction

    Sorafenib 200mg should be taken on an empty stomach one hour before the meal or 2 hours after the meal because the use of this medicine delays the absorption in presence of food.

    Drug-Disease Interaction

    Lung toxicity

    Therapy should be administered with caution in patients who are with a history of interstitial pneumonia and pulmonary fibrosis because the use of these multikinase inhibitors may cause pulmonary toxicity.


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 30°C in a refrigerator.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag


    Fast Tag

    • Sorafenat 200mg Tablet contains Sorafenib 200mg used to treat renal cell carcinoma (kidney cancer), Hepatocellular carcinoma (hepatic cancer), and Thyroid Cancer. It is not recommended in pediatric use.
    • Take this medicine 1 hour before or 2 hours after your meal
    • Closely monitor the patient kidney function and blood cell count while you are receiving this medicine
    • Kindly inform your doctor if you have experienced headache, stomach pain, and blood in your stool and urine while you are receiving this medicine.


    References