Spegra Tablet - 30 Tablets Pack

Brand Name Spegra Tablet - 30 Tablets Pack
Salt Composition Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)
Strength 50mg + 200mg + 25mg
Product Form Tablet
Storage Store at room temperature (10-30°C)
Category HIV
Country of Origin India
Manufacturer Emcure Pharmaceuticals Ltd
Manufacturer/Marketer AddressEmcure Pharmaceuticals Ltd, 255/2, Hinjawadi, Pune - 411057, India.
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Spegra Tablet, Dolutegravir 50mg, Emtricitabine 200mg, Tenofovir Alafenamide 25mg, price, Uses, Side Effects - Drugcarts watermark
M.R.P : Rs.4388.50       Price : Rs.3291.38

You Save : Rs.1,097.12    Inclusive of all taxes

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Availability : In Stock


    Medical Description of Spegra Tablet - 30 Tablets Pack

    Spegra Tablet contains Dolutegravir 50mg, Emtricitabine 200mg and Tenofovir Alafenamide 25mg. Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)) is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection. Dolutegravir is an integrase strand transfer inhibitor. Emtricitabine and Tenofovir Alafenamide is a nucleoside reverse transcriptase inhibitor. Spegra tablet works by reducing the viral load of HIV in your body. Spegra tablet improves your immune system and reduces the risk of conditions associated with HIV infection. 


    Spegra Tablet - 30 Tablets Pack Uses

    Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)) tablet is used to treat adults and children above the weight class 40kg only who are infected by HIV-1. Spegra tablet is not indicated for its use as pre-exposure prophylaxis.


    Spegra Tablet - 30 Tablets Pack Benefits

    Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)) tablet is used to help control HIV infection. Spegra tablet helps to decrease the amount of HIV in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Spegra tablet is not a cure for HIV infection, it improves immunity that results in longevity of life. It is recommended for use in children from 40 kgs and in adults.


    Spegra Tablet - 30 Tablets Pack Indication

    Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)) tablet is indicated in the treatment of HIV infection that causes AIDS in humans. Spegra tablet boosts the immunity of the affected hosts. Spegra tablet is indicated in adults and children above 40kgs.


    Mechanism of action of Spegra Tablet - 30 Tablets Pack

    Spegra Tablet contains Dolutegravir 50mg, Emtricitabine 200mg and Tenofovir Alafenamide 25mg. Dolutegravir inhibits strand transfer activity of integrase in DNA thus blocks replication of HV-1. Emtricitabine is an analogue of cytidine that is phosphorylated to its active form Emtricibine 5 triphosphate that inhibits the activity of HIV-1 reverse transcriptase and incorporates themselves into the DNA thus results in termination of the replication process. Tenofovir Alafenamide enters hepatocytes where it is converted to tenofovir by hydrolysis. Hepatocyte tenofovir is then phosphorylated into tenofovir-diphosphate that incorporates themselves into the DNA strand thus stops the replication of viral particles. Thus, the active HIV molecules become inactive and further reproduction and multiplication process is stopped.


    How Spegra Tablet - 30 Tablets Pack works

    Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)) tablet is an integrase inhibitor and nucleoside reverse transcriptase inhibitor. Dolutegravir inhibits the transfer of integrase in DNA and Emtricitabine and tenofovir incorporates themselves into the DNA thus stops the replication of viral particles. Thereby preventing the formation of mature virus particles into infectious virions that spreads the infection.


    Spegra Tablet - 30 Tablets Pack Contraindication

    Absolute contraindication:

    • if you are allergic to Spegra (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)) tablet and its contents
    • if you are pregnant
    • if you are diabetic

    Relative contraindication:

    • if you have a liver disorder like hepatitis B or C or Child-Pugh disease
    • if you have blood disorders
    • if you have renal diseases


    Spegra Tablet - 30 Tablets Pack Side Effects

    Very common side effects that occur in more than 1:10 patients: Diarrhea, headache, nausea

    Common side effects that occur 1:10 patients: Rash, pruritus, vomiting, Flatulence, Abdominal pain, Anemia, Allergic reaction, Impaired concentration, Lipodystrophy, Metabolic acidosis, Leukopenia, Thrombocytopenia, Weakness, insomnia, abnormal dreams, depression dizziness, tiredness, changes in LFT and increased creatine kinase

    Uncommon side effects that occur 1:100 patients: lactic acidosis, hepatitis B flare up, suicidal thoughts and behaviours, joint and muscle pain

    Rare side effects that occur 1:1000 patients: osteonecrosis


    FAQs for Spegra Tablet - 30 Tablets Pack

    Is Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg))  safe during pregnancy?

    No, Spegra tablet is not safe during pregnancy. Consult your physician.

    Can Spegra tablet be taken while breastfeeding?

    No, in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding.

    Can Spegra tablet be taken while alcohol consumption?

    The interaction is unknown but this medication causes side effects. Thus, consult your physician.

    Can I take a drive or operate heavy machineries while on Spegra tablet?

    This medication causes side effects thus caution is used while driving or operating machineries.

    Can Spegra tablet be taken as a prophylactic to exposure?

    No, Spegra tablet cannot be taken as a prophylactic.


    Precautions and general warning of Spegra Tablet - 30 Tablets Pack

    Alcohol

    Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution as Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg))  causes side effects. For further queries, consult your physician.

    Pregnancy

    The use of Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)) is not recommended during pregnancy. Consult your physician.

    Breast Feeding

    The use of Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)) during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effects in newborn.

    Kidney Problem

    Renal filtration impairment and kidney stone formation – monitor function. For further queries, consult your physician.

    Liver Disease

    Liver disorders and diseases like hepatitis B or C, Child-Pugh disease

    Monitor liver function before and during therapy, especially in patients with other


    How to Take Spegra Tablet - 30 Tablets Pack

    Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg))  is taken orally with or without food at regular time.

    Spegra tablet should not be crushed or chewed it must be swallowed.

    After therapy has been initiated, do not take more or less of Spegra medicine than prescribed or stop taking it without your physicians’ approval. Skipping or changing the Spegra tablet dose without approval may cause the amount of the virus to increase making the infection more difficult to treat, or worsen side effects.


    Use of Spegra Tablet - 30 Tablets Pack in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.

    The recommended dosage for Spegra (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)) tablet is one tablet taken once per day

    These medicines must be taken with food on a regular time basis.


    Use of Spegra Tablet - 30 Tablets Pack in children

    The recommended dosage of Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg))  is one tablet taken once per day


    Use of Spegra Tablet - 30 Tablets Pack in Elderly Patients

    Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)) has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • New onset diabetes mellitus or hyperglycaemia – Monitor blood glucose and insulin levels. When needed add oral hypoglycemic and insulin
    • Blood disorders Hemophilia, hemolytic anemia
    • Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
    • Accumulation or Redistribution of body fat or
    • immune reconstitution syndrome.
    • Any sign of infection – fever or lymph node enlargement
    • Lactose intolerance or galactose malabsorption


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have a kidney problem

    If you are pregnant or breastfeeding


    General instructions

    Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg))  is an antiviral taken orally as a prescribed dosage at a specific time regularly with food.


    Drug Interaction of Spegra Tablet - 30 Tablets Pack

    Drug-Drug Interaction

    Side effects are increased by aceclofenac, acyclovir, amikacin

    Serum concentration increased by Bisoprolol, Clarithromycin, clomifene, acetaminophen

    Decreased absorption caused by Magnesium/aluminum-containing antacid, Acetazolamide

    Drug-Food Interaction

    Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg))  can be safely taken with food, if doubts arise kindly refer to your physician. Spegra tablet generally causes side effects thus it is advised not to be taken with alcohol.

    Drug-Disease Interaction

    • Electrolyte disorders – Gettleman or Barter syndrome. Consult physician before use
    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
    • Pancreatitis disorders – used with caution in pancreatitis. Consult a physician before use


    Over Dose

    Contact your doctor, pharmacist or nurse immediately.


    Missed Dose

    In general, if you take once a day dosage, the missed single dose of Spegra tablet can be taken within the next 12 hrs, you can take it. If it is more than 12 hrs, skip the dose and take the next dose at the recommended time. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 30?C


    Fast Tag

    Spegra tablet (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg))  is a reverse transcriptase and integrase inhibitor.

    Spegra tablet is used to control and treat HIV infection.

    Do not use this medication while pregnant or lactation period.

    Don’t use this medication with liver disease and kidney diseases.

    This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury, etc.