Drug Interaction of Spiropirf 200mg Tablet
Carbamazepine + Pirfenidone
Carbamazepine decreases the effect of pirfenidone by affecting the hepatic enzymes metabolism. The use of this drug is contraindicated.
Aminolevulinic acid + Pirfenidone
A combination of this drug either increases the toxicity of the other by pharmacodynamic synergism. Use alternative drug
Cimetidine + Pirfenidone
Cimetidine increases the effect of pirfenidone by affecting the hepatic enzyme metabolism. Use alternative drug
Ciprofloxacin + Pirfenidone
Ciprofloxacin increases the effect of pirfenidone by affecting the hepatic enzyme metabolism. Use alternative drugs.
Smoking may alter the effect of pirfenidone so the patient should not smoke while taking pirfenidone
The patient who is taking pirfenidone has been noticed that there is an increase in ALT and AST levels with or without an increase in bilirubin. Pirfenidone should be administered with caution to the patient with mild to moderate hepatic impairment.
Pirfenidone should be administered with caution to the patient with mild to moderate, severe renal impairment due to serious side effects.