Stadin Plus Tablet
Brand Name | Stadin Plus Tablet |
Salt Composition |
Lamivudine (150mg) + Stavudine (30mg) |
Strength | 150mg + 30mg |
Product Form | Tablet |
Pack | 10 Tablet(s) in Strip |
Storage | Store below 30°C |
Category |
HIV |
SubCategory |
HIV |
Country of Origin | India |
Manufacturer |
Sain Medicaments Pvt Ltd |
Manufacturer/Marketer Address | Sain Medicaments Pvt Ltd, 10, H.V.E.S, Building Complex, Kandaswamy Lane, Sultan Bazar Hyderabad-500029, Andhra Pradesh, India |
You Save : Rs.16.12 Inclusive of all taxes
- if you are allergic to Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet and its contents
- if you are pregnant
- if you are breastfeeding
- if you have a liver disorder like hepatitis B or C or Child-Pugh disease
- if you have neurologic disorders
- if you have pancreatitis
- if you have renal diseases
- if you are diabetic
- Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
- Pancreatitis
- Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
- New onset diabetes mellitus or hyperglycemia – Monitor blood glucose and insulin levels. When needed add oral hypoglycemic and insulin
- Accumulation or Redistribution of body fat or
- immune reconstitution syndrome.
- Any sign of infection – fever or lymph node enlargement
- Liver disorders – used with caution in severe liver diseases. Consult a physician before use
- Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
- Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
- Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
- Pancreases disorders – used with caution in pancreatitis. Consult a physician before use
Medical Description of Stadin Plus Tablet
Stadin Plus Tablet contains Lamivudine 150mg and stavudine 30mg. Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection. Stadin Plus tablet is a nucleoside reverse transcriptase inhibitor. Stadin Plus tablet works by reducing the viral load of HIV in your body. It improves your immune system and reduces the risk of conditions associated with HIV infection.
Stadin Plus Tablet Uses
Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet is used to treat adults and children above 12 years of age who are infected by HIV-1. Stadin Plus tablet can be taken in combination with other anti-HIV medicines. Your doctor will discuss which combination of medicines is best for you.
Stadin Plus Tablet Benefits
Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet is used with other anti-HIV medicines to help control HIV infection. Stadin Plus tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Stadin Plus tablet is a nucleoside reverse transcriptase inhibitor. It is not a cure for HIV infection, it improves immunity that results in longevity of life. It is not recommended for use in children less than 12 years of age due to the increased risk of serious side effects.
Stadin Plus Tablet Indication
Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet is indicated in the treatment of HIV-1 infection that causes AIDS in humans. Stadin Plus tablet is used with other antiviral medications to boost the immunity of the affected hosts. Stadin Plus tablet is indicated in ages above 12 years of age.
Mechanism of action of Stadin Plus Tablet
Stadin Plus tablet contains Lamivudine 150mg and Stavudine 30mg. Lamivudine present in Stadin Plus tablet is an HIV-1 nucleoside reverse transcriptase inhibitor. Lamivudine is phosphorylated to its active forms lamivudine triphosphate that is incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Stavudine is a nucleoside reverse transcriptase inhibitor that is phosphorylated into stavudine -5- triphosphate. Stavudine-5-triphosphate battle with deoxythymidine triphosphate and incorporate themselves into the DNA of HIV molecular structure. After they incorporate within the DNA of HIV molecule the further process such as transcription, reverse transcriptase enzyme is inhibited. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.
How Stadin Plus Tablet works
Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Stadin Plus tablet inhibits the action of HIV-1 reverse transcriptase enzyme by incorporating themselves into the nucleotide sequence thus inhibits the action of the reverse transcriptase of HIV-1, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection and improves immunity.
Stadin Plus Tablet Contraindication
Absolute contraindication:
Relative contraindication:
Stadin Plus Tablet Side Effects
Common side effects that occur 1:10 patients: Headache, Cough, nausea, vomiting, abdominal pain or cramps, diarrhoea, Rash, alopecia, Arthralgia, Myalgia, Fatigue, malaise, fever, Back pain. Neutropenia, Thrombocytopenia, increase in AST, ALT bilirubin levels.
Uncommon side effects that occur 1:100 patients: anaemia, Insomnia, Anxiety, Depression, Pancreatitis, Peripheral neuropathy
Rare side effects that occur 1:1000 patients: Pure red cell aplasia, Lactic acidosis, Pancreatitis, elevations in serum amylase, Hepatitis, Angioedema, Rhabdomyolysis, cardiomyopathy, convulsions, lipodystrophy, lactic acidosis
Very rare side effects that occur 1:10,000 patients: erythema multiform, Stevens–Johnson syndrome, toxic epidermal necrolysis, hepatic failure
FAQs for Stadin Plus Tablet
Is Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet safe during pregnancy?
No, taking Stadin Plus tablet during is not recommended unless the pros outweigh the cons. Consult your physician.
Can Stadin Plus tablet be taken while breastfeeding?
No, in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding.
Can Stadin Plus tablet be taken while alcohol consumption?
The interaction is unknown but this medication causes side effects. Thus, consult your physician.
Can I take a drive or operate heavy machineries while on Stadin Plus tablet?
This medication causes side effects thus caution is used while driving or operating machineries.
Is Stadin Plus tablet habit forming?
No, Stadin Plus tablet is not habit-forming.
Precautions and general warning of Stadin Plus Tablet
Alcohol
Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, Consult your physician.
Driving or operating machinery
It is preferred to drive or operate heavy machinery with caution as Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet causes side effects. For further queries, consult your physician.
Pregnancy
The use of Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet is not recommended during pregnancy unless the pros outweigh the cons.
Breast Feeding
The use of Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effects in newborn.
Kidney Problem
Renal filtration impairment – monitor function.
Liver Disease
Liver disorders and diseases like hepatitis B or C, Child-Pugh disease
Monitor liver function before and during therapy
How to Take Stadin Plus Tablet
Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet is taken orally without food.
Stadin Plus tablet must be taken at the same time every day as prescribed by your physician.
Stadin Plus tablet can be taken with other antivirals.
After therapy has been initiated, do not take more or less Stadin Plus medicine than prescribed or stop taking it without your physicians’ approval. Skipping or changing Stadin Plus tablet dose without approval may cause the amount of the virus to increase making the infection more difficult to treat, or worsen side effects.
Use of Stadin Plus Tablet in Adult
If you are pregnant or breastfeeding inform your physician as they are not advisable.
The recommended dosage for Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet is one tablet taken twice per day
Stadin Plus tablet can be taken with other antivirals as prescribed by the physician without fail. These medicines must be taken without food on a regular time basis either 2 hours before food or 2 hours after food intake
Use of Stadin Plus Tablet in children
The recommended dosage is one tablet of Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet taken twice a day on empty stomach.
Stadin Plus tablet can be taken with other antivirals as prescribed by the physician without fail. These medicines must be taken without food on a regular time basis either 2 hours before food or 2 hours after food intake
Caution is used in cases where the creatine clearance rate is <50ml/min
Use of Stadin Plus Tablet in Elderly Patients
Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.
Other general warnings
Talk to your doctor if
If you have any allergy
If you have a liver problem
If you have a kidney problem
If you are pregnant or breastfeeding
General instructions
Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet is taken with other antivirals orally as prescribed dosage at a specific time regularly.
Drug Interaction of Stadin Plus Tablet
Drug-Drug Interaction
Serum concentration decreased by Acetazolamide, Potassium citrate
Serum concentration increased by Aceclofenac, Acetaminophen, Alprazolam
severity of adverse effects is increased by Acyclovir, Amphotericin B, Baclofen
Drug-Food Interaction
Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. Stadin Plus tablet generally causes side effects thus it is advised not to be taken with alcohol.
Drug-Disease Interaction
Over Dose
Contact your doctor, pharmacist or nurse immediately.
Missed Dose
If you take twice a day dosage, then the missed dosage if you notice within 6 hours. If it is more than 6 hours, then skip the dosage and take the next doses as usual. Always take with other antivirals Don’t take a double dose for a forgotten dose.
Storage and Disposal
Keep the medication out of children’s reach
Keep the medication away from pets
Once expired dispose immediately
Store at 30°C
Fast Tag
Stadin Plus (Lamivudine (150mg) + Stavudine (30mg)) tablet is a nucleoside reverse transcriptase inhibitor.
Stadin Plus tablet is used to control and treat HIV infection with other antivirals
Do not use this medication while pregnant or lactation period.
Don’t use this medication with liver disease and kidney diseases.
This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury etc.