Synclar Paediatric Dry Syrup

Synclar Paediatric Dry Syrup contains Clarithromycin 125mg used to treat bacterial infections such as Bronchitis, Community-acquired pneumonia, Tonsillitis/Pharyngitis, Sinusitis, Otitis media, Skin and skin structure infections, and Peptic ulcer disease. Clarithromycin 125mg is an antibiotic used to treat various bacterial infections in children. Mainly this bacterial infection targets the respiratory tract, ear, nose, throat, lungs, and skin. It is also used to treat bacterial infections that occur in children who are with HIV due to their weak immune systems and it is also effective against H.pylori-associated peptic ulcer diseases. This medicine is not used for common flu and cold symptoms that occur due to viral infections. This medicine is commonly prescribed for cough and colds caused by bacterial infections.

It is used in the treatment of the following conditions as bacterial infections such as Bronchitis, Community-acquired pneumonia, Tonsillitis/Pharyngitis, Sinusitis, Otitis media, Skin and skin structure infections, and Peptic ulcer disease.

Bacterial infections

Bacterial infection occurs when bacteria enter your body and start multiplying which may cause tissue damage and make you sick. Mostly it is caused by Staphylococcus and Streptococcus organisms. The bacterial diseases are cholera, bacterial meningitis, tetanus, gonorrhea, pneumonia, and syphilis. Symptoms include fever, chills, and sweats, inflamed lymph nodes, headache, diarrhea, abdominal pain

Acute bronchitis

It is a viral infection that causes inflammation in the bronchial tubes. It is mostly caused by rhinovirus, adenovirus, influenza A and B, and parainfluenza virus. Symptoms include cough, fatigue, breathing difficulty, fever and chills, and chest discomfort.

Lower respiratory tract infections

Infection in the lungs especially in the lower airways Common infections are Bronchiolitis and Pneumonia which are caused by Streptococcus pneumonia. Symptoms include runny nose, dry cough, sore throat, low-grade fever, and headache.

Skin infection

It is usually caused by bacteria, fungi, viruses, and parasites. Common skin infection includes cellulitis, impetigo. Symptoms include red skin, blisters, swelling, pain, red spots, and tenderness

Community-acquired pneumonia

Infection and inflammation to the respiratory air sacs of lungs called pneumonia caused by bacteria. This medicine is used to treat this bacterial infection.

Tonsillitis/Pharyngitis

Infection of the swelling and soreness in the throat and tonsils is called pharyngitis and tonsillitis. The infection that affects both throat and tonsil is called pharyngotonsillitis. It is caused by bacteria. This medicine is used to treat this infection.

Sinusitis

Infection to the nasal passages is caused by bacteria called sinusitis. This medicine is used to treat this bacterial infection.

Otitis media

It is also called an ear infection. While compared with adults children are more prone to this infection. It is caused by Streptococcus pneumonia. Symptoms include ear pain, difficulty in sleeping, loss of balance, headache, loss of appetite, and drainage of fluid from the ear.

Infection to the ear is called otitis media. It should be caused by bacteria. This medicine is used to treat this bacterial infection.

Peptic ulcer

It is a disease caused by Helicobacter pylori bacteria then it causes gastritis and peptic ulcer disease. H.Pylori bacteria mainly affects the lining of the stomach and has less effect on acid secretion. This medicine is used to treat this bacterial infection.

The Synclar Paediatric Dry Syrup is prescribed in the following indications as Bronchitis, Community-acquired pneumonia, Tonsillitis/Pharyngitis, Sinusitis, Otitis media, Skin and skin structure infections, and Peptic ulcer disease.

Synclar Paediatric Dry Syrup contains Clarithromycin 125mg is a macrolide antibiotic that produces its action by preventing the protein synthesis which is essential for the bacteria to function and it also prevents the infection from spreading.

Synclar Paediatric Dry Syrup contains Clarithromycin 125mg is a macrolide antibiotic that produces its action by preventing the protein synthesis which is essential for the bacteria to function and it also prevents the infection from spreading.

• Do not take this medicine if you are allergic to Clarithromycin
• It is contraindicated to use this medicine along with pimozide, cisapride, ergotamine and dihydroergotamine
• Kindly avoid taking this medicine if you have a history of cholestatic jaundice or any hepatic dysfunction
• Avoid taking Clarithromycin with Colchicine in patients with renal or hepatic impairment
• Combination with HMG-CoA reductase inhibitors (statins) metabolized by CYP3A4 due to an increased risk of developing myopathy including rhabdomyolysis

• Gastrointestinal effects
• Abnormal taste
• Diarrhea
• Elevated blood urea nitrogen
• Abdominal pain
• Rash
• Dyspepsia
• Heartburn
• Elevated prothrombin time
• Clostridium difficile colitis
• Hallucinations
• Hypoglycemia
• Increased alkaline phosphatase
• Increased aspartate aminotransferase
• Leukopenia
• Neutropenia

• Is the Synclar Paediatric Dry Syrup is effective?

Yes, it is considered effective when you have taken the medication as per the dose and duration advised by the doctor. If you stop the medicine without completing the course of treatment it may worsen the conditions

• My child is suffering from a muscle weakness disorder. Is it safe to give Synclar Paediatric Dry Syrup?

The medicine should be administered with caution in children who are having neuromuscular disorders like Myasthenia gravis because the use of this medicine may worsen your conditions

• Can I get my child vaccinated while on treatment with Synclar Paediatric Dry Syrup?

The use of antibiotics does not interfere with the ingredients in the vaccines. But as a preventive measure do not vaccinate your children until they recover from the illness.

Alcohol

Since it is used in children's no information is available regarding the use of this medicine. Kindly consult with your doctor

Driving or operating machinery

Since it is used in children's no information is available regarding the use of this medicine. Kindly consult with your doctor

Pregnancy

Since it is used in children's no information is available regarding the use of this medicine. Kindly consult with the doctor

Breast Feeding

Since it is used in children's no information is available regarding the use of this medicine. Kindly consult with the doctor

Kidney Problem

The medicine should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

Liver Disease

It is considered safe to use this medicine if you have liver dysfunctions. It does not require dose modification. Kindly consult with your doctor.

Synclar Paediatric Dry Syrup is taken orally with or without food. You can measure the dose with the help of a measuring cup and shake well before using this dry syrup. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.

It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor.

It is considered unsafe to use this medicine in children who are below 6 months old. Kindly consult with your doctor.

Since it is used in children's no information is available regarding the use of this medicine. Kindly consult with the doctor

• Therapy should be administered with caution because it is associated with QT interval prolongation and arrhythmias
• The use of this medicine may cause hepatic dysfunction like increased liver enzyme activity, hepatocellular and cholestatic hepatitis with or without jaundice.
• Kindly discontinue the treatment if you have noticed dark urine, tender abdomen, jaundice, anorexia, and pruritus
• The use of this medicine may cause Clostridium difficile associated diarrhea

• You have a history of gastrointestinal disease
• You are not responding to the treatment
• You have experienced any allergic reaction like rashes and itching

Synclar Paediatric Dry Syrup contains Clarithromycin 125mg used to treat bacterial infections such as Bronchitis, Community-acquired pneumonia, Tonsillitis/Pharyngitis, Sinusitis, Otitis media, Skin and skin structure infections, and Peptic ulcer disease. Clarithromycin is an antibiotic used to treat various bacterial infections in children. Mainly this bacterial infection targets the respiratory tract, ear, nose, throat, lungs, and skin. It is also used to treat bacterial infections that occur in children who are with HIV due to their weak immune systems and it is also effective against H.pylori-associated peptic ulcer diseases.

Drug-Drug Interaction

BCG vaccine live

The use of this drug is contraindicated because the use of medicine decreases the effect of the BCG vaccine live by pharmacodynamic antagonism

Cabergoline

The use of this medicine is contraindicated because the use of clarithromycin may increase the effect of cabergoline by decreasing its metabolism.

Chloroquine

The use of this medicine is contraindicated because the use of chloroquine increases the toxicity of clarithromycin by QTc interval

Lovastatin

The use of clarithromycin will increase the effect of lovastatin by P-glycoprotein efflux transporter

Aripiprazole

Use alternative drugs because the use of clarithromycin will increase the effect of aripiprazole by affecting hepatic or intestinal enzyme metabolism

Digoxin

Therapy should be administered with caution because the use of clarithromycin will increase the effect of digoxin by P-glycoprotein efflux transporter

Drug-Food Interaction

The use of grape juice along with clarithromycin may affect gastrointestinal absorption and it also inhibits the metabolism of clarithromycin.

Drug-Disease Interaction

Gastrointestinal diseases

It should be used with caution in patients with gastrointestinal diseases, particularly colitis (infection to the inner lining of the colon). It will lead to worsening the patient’s health condition. If you are noticed severe diarrhea, abdominal pain, blood in stools, etc. immediately inform the doctor. Based on the patient clinical condition, dose adjustment is needed.

QT Prolongation

Therapy should be administered with caution because the use of clarithromycin may cause prolonged cardiac repolarization, QT interval in patients who are having a history of congenital long QT syndrome, bradyarrhythmias, proarrhythmic conditions such as uncorrected hypokalemia, hypomagnesemia

Renal dysfunction

Clarithromycin should be administered with caution because the use of this medicine gets eliminated by the kidney. It is not necessary to adjust the dose in patients with mild to moderate renal impairment.

Myasthenia gravis

Therapy should be administered with caution in patients with a history of myasthenia gravis because the use of macrolide antibiotics may worsen the conditions

Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.

Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

• Stored at 10-30°C room temperature.
• Protect from light and heat.
• Keep away from children and pets. Otherwise, it becomes toxic to them.
• Disposed of properly in a suitable bag.

Synclar Paediatric Dry Syrup contains Clarithromycin 125mg used to treat bacterial infections such as Bronchitis, Community-acquired pneumonia, Tonsillitis/Pharyngitis, Sinusitis, Otitis media, Skin and skin structure infections, and Peptic ulcer disease. It reduces bacterial growth by preventing the synthesis of essential proteins required by bacteria to carry out vital functions.

This medicine is not used for common flu and cold symptoms. And not treat viral infections. This medicine is commonly prescribed for cough and colds caused by bacterial and parasitic infections.

This medicine is contraindicated to allergic symptoms such as skin rash, itching, swelling and breathing difficulties, liver damage, and statins.

• Chambers HF, Dougall CM. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1370-75.

• KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 755-756.

• · Drugs, H., 2020. Clarithromycin: Medlineplus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 19 December 2020].

• https://medlineplus.gov/druginfo/meds/a692005.html>

• · Drugbank.ca. 2020. Clarithromycin | Drugbank Online. [online] Available at: < [Accessed 19 December 2020].

• https://www.drugbank.ca/drugs/DB01211>

• · Accessdata.fda.gov. 2020. [online] Available at: < [Accessed 19 December 2020].

• https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050662s042,050698s024,050775s013lbl.pdf>

• · Medicines.org.uk. 2020. Clarithromycin 250 Mg/5Ml Suspension-Summary Of Product Characteristics (Smpc)-(Emc). [online] Available at: < [Accessed 19 December 2020].

• https://www.medicines.org.uk/emc/product/4230/smpc>