Synmega 250mg/125mg Tablet

Synmega 250mg/125mg Tablet contains Ampicillin 250mg and Salbactum 125mg used to treat bacterial infections such as Gynecologic infections, Intra-Abdominal infections, Skin and skin structure infections, Orbital cellulitis, Pelvic inflammatory diseases, Pneumonia, and Urinary tract infections. Mainly this medicine targets the throat, ear, nasal sinuses, respiratory tract, urinary tract, skin, and soft tissue. Ampicillin 250mg is a penicillin derivative that is effective against both gram-negative and gram-positive bacteria and helps to kill the bacteria. Sulbactam 125mg is an antibiotic used to treat severe bacterial infections. Usually, it is prescribed in a combination with other antibiotics to prevent the infection and reduce the resistance against the antibiotics. The combination of this medicine helps to fight against the infection. This medicine is not used for common flu and cold symptoms that occur due to viral infections. This medicine is commonly prescribed for cough and colds caused by bacterial infections.

It is used in the treatment of the following conditions Bacterial infections, Gynecologic infections, Intra-Abdominal infections, Skin and skin structure infections, Orbital cellulitis, Pelvic inflammatory diseases, Pneumonia, and Urinary tract infections.

Bacterial infections

Bacterial infection occurs when bacteria enter your body and start multiplying which may cause tissue damage and make you sick. Mostly it is caused by Staphylococcus and Streptococcus organisms. The bacterial diseases are cholera, bacterial meningitis, tetanus, gonorrhea, pneumonia, and syphilis. Symptoms include fever, chills, and sweats, inflamed lymph nodes, headache, diarrhea, abdominal pain

Urinary tract infection

It is a type of infection that affects the urethra, kidneys, and bladder. It is caused by Escherichia coli (E.coli). Symptoms include abdominal pain, frequent urination, dysuria, blood in urine, foul-smell while urinating

Acute bronchitis

It is a viral infection that causes inflammation in the bronchial tubes. It is mostly caused by rhinovirus, adenovirus, influenza A and B, and parainfluenza virus. Symptoms include cough, fatigue, breathing difficulty, fever and chills, and chest discomfort.

Lower respiratory tract infections

Infection in the lungs especially in the lower airways Common infections are Bronchiolitis and Pneumonia which are caused by Streptococcus pneumonia. Symptoms include runny nose, dry cough, sore throat, low-grade fever, and headache.

Acute sinusitis

It is also called acute rhinosinusitis.  It is an inflammation inside your nose which is called sinusitis. It is usually caused by the common cold, or by any viral or bacterial infection. Symptoms include runny nose, postnasal drainage, congestion, swelling around your eyes, ear pressure, headache, cough, bad breath, fatigue, and fever.

Ear, Nose and Throat infection

Ear, Nose, and Throat infection includes Tonsillitis, Ear infections, Sinus infections.

Tonsillitis

Inflammation of tonsils is called tonsillitis which causes server throat pain and is caused by Streptococcus pyogenic. Symptoms include inflamed tonsils, sore throat, difficulty in swallowing, bad breath, headache, and inflamed lymph nodes

Ear infection

While compared with adults children are more prone to this infection. It is caused by Streptococcus pneumonia. Symptoms include ear pain, difficulty in sleeping, loss of balance, headache, loss of appetite, and drainage of fluid from the ear.

Genitourinary tract infection

It is a type of infection that affects the urethra, kidneys, and bladder. It is caused by Escherichia coli (E.coli). Symptoms include abdominal pain, frequent urination, dysuria, blood in urine, foul-smell while urinating

Skin infection

It is usually caused by bacteria, fungi, viruses, and parasites. Common skin infection includes cellulitis, impetigo. Symptoms include red skin, blisters, swelling, pain, red spots, and tenderness

Gynecological infections

Infection to the vagina or genital tract caused by E.coli, anaerobic gram-positive coccus, etc called gynecological infections to include endometriosis, pelvic inflammatory diseases, etc.

Pelvic inflammatory diseases

It is also called pelvic infection. It is an infection of the female reproductive organs that occur in the female upper genital tract. It usually occurs when sexually transmitted bacteria spread via the vagina to the uterus, fallopian tubes, and ovaries. Symptoms include pain in the pelvic region, abnormal vaginal discharge, uterine bleeding, pain during intercourse, fever, and difficulty in urination.

Gonorrhea

It is a sexually transmitted infection caused by bacteria called Neisseria gonorrhoeae. It affects both males and females. Symptoms include thick discharge from the penis, increased vaginal discharge, pain while urinating, anal itching, discharge, and spotting between menstrual bleeding.

Community-acquired pneumonia

Pneumonia that occurs outside of the hospital. It is caused by Streptococcus pneumonia, Mycoplasma pneumonia. Symptoms include chest pain, cough, confusion, shortness of breath, and fatigue.

Synmega 250mg/125mg Tablet is prescribed in the following indications such Bacterial infections, Gynecologic infections, Intra-Abdominal infections, Skin and skin structure infections, Orbital cellulitis, Pelvic inflammatory diseases, Pneumonia, and Urinary tract infections.

The Synmega 250mg/125mg Tablet contains Ampicillin 250mg and Sulbactam 125mg it is a combination of two medicines. Ampicillin 250mg is a penicillin derivative that has a bactericidal effect that produces its action by killing the bacterial cell wall which is needed for the multiplication of bacteria. Sulbactam 125mg is a beta-lactamase inhibitor that produces its action by inhibiting the enzymes which are produced by the bacteria. This enzyme inactivates the effect of the antibiotic. The combination with Subactum helps to reduce the development of resistance and increase the action of ampicillin against bacteria.

The Synmega 250mg/125mg Tablet contains Ampicillin 250mg and Sulbactam 125mg it is a combination of two medicines. Ampicillin 250mg is a penicillin derivative that has a bactericidal effect that produces its action by killing the bacterial cell wall which is needed for the multiplication of bacteria. Sulbactam 125mg is a beta-lactamase inhibitor that produces its action by inhibiting the enzymes which are produced by the bacteria. This enzyme inactivates the effect of the antibiotic. The combination with Subactum helps to reduce the development of resistance and increase the action of ampicillin against bacteria.

• Do not take this medicine if you are allergic to penicillins, cephalosporins, and Carbapenems
• It is contraindicated to use this medicine in patients who are having a previous history of cholestatic jaundice, hepatic dysfunction that is associated with ampicillin and sulbactam

• Diarrhea
• Thrombophlebitis
• Black, hairy tongue
• Candidiasis
• Dysuria
• Flatulence
• Glossitis
• Mucosal bleeding
• Pseudomembranous colitis
• Thrombocytopenia

• How long does the Synmega 250mg/125mg Tablet take to work?

Usually, the use of this medication produces its action as soon as you started taking this medicine. But it may 2 to 3 days to get relief from symptoms.

• Can I stop taking Synmega 250mg/125mg Tablet when my symptoms are relieved?

No, you should withdraw the medicine without completing the full course of treatment even if you feel better because it may worsen your condition

• Can the use of the Synmega 250mg/125mg Tablet cause diarrhea?

Yes, the use of this medicine may cause diarrhea since it is an antibiotic it kills both harmful and good bacteria in your intestine and stomach and leads to diarrhea. Kindly consult with your doctor if your symptom persists.

Alcohol

The use of alcohol does not produce harmful effects while you are receiving this treatment. Kindly consult with your doctor.

Driving or operating machinery

It is not clear that the use of this medicine may affect the ability to drive. Kindly consult with your doctor.

Pregnancy

It is considered safe to use this medicine during pregnancy. It does not produce a harmful effect on the fetus. Kindly consult with your doctor

Breast Feeding

Therapy should be administered with caution in patients who are receiving this medicine during pregnancy. Kindly consult with your doctor.

Kidney Problem

The medicine should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

Liver Disease

Limited information is available regarding the use of this medicine in patients who are having a history of hepatic impairment. Kindly consult with your doctor.

Synmega 250mg/125mg Tablet is taken orally on an empty stomach. You should not chew, cut or crush the tablet. Take this medicine as per the dose and duration advised by your doctor. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.

It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor.

It is considered unsafe to use this medicine in children who are below 1 year old. Kindly consult with your doctor.

The Synmega 250mg/125mg Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

• Kindly adjust the dose in patients who are with renal failure
• Long-term use may cause fungal or bacterial superinfection
• The use of this medicine may cause hepatic dysfunction like hepatitis, cholestatic jaundice, and hepatic toxicity
• The patients who are with infectious mononucleosis have higher chances for developing rash during the therapy
• The use of this medicine may cause severe skin reactions such as toxic epidermal necrolysis, stevens-Johnson syndrome, dermatitis, and erythema multiforme

                 Antibiotic resistance

• Finish the complete course of antibiotics even if you feel better. Otherwise, it will lead to Antibiotic resistance (the bacteria may be resistant to antibiotics).

• You have a history of gastrointestinal disease
• You are not responding to the treatment
• You are having any concomitant diseases

Ampicillin 250mg and Sulbactam 125mg are a combination of two medicines. Ampicillin 250mg is a penicillin derivative that has a bactericidal effect that produces its action by killing the bacterial cell wall which is needed for the multiplication of bacteria. Sulbactam 125mg is a beta-lactamase inhibitor that produces its action by inhibiting the enzymes which are produced by the bacteria. This enzyme inactivates the effect of the antibiotic.

Drug-Drug Interaction

BCG vaccine live

The use of this drug is contraindicated because the use of ampicillin decreases the effect of the BCG vaccine live by pharmacodynamic synergism

Demeclocycline

Use alternative drugs because the use of demeclocycline decreases the effect of ampicillin by pharmacodynamic antagonism

Mycophenolate

Use an alternative drug because the combination of this drug either increases the effect of the other by decreasing its renal clearance.

Aspirin

Therapy should be administered with caution because the combination of this medicine either increases the effect of the other by plasma protein binding competition.

Chloroquine

Therapy should be administered with caution because the use of chloroquine decreases the effect of ampicillin by inhibiting the absorption of GI

Pantoprazole

Therapy should be administered with caution because the use of pantoprazole will decrease the effect of ampicillin by increasing its gastric PH.

Ethinyl estradiol

Therapy should be administered with caution because the use of ampicillin will decrease the effect of Ethinyl estradiol by altering the intestinal flora and it also increases the risk for developing contraceptive failure.

Drug-Food Interaction

Ampicillin should be administered one hour before or two hours after your meals because the use of this medicine may reduce absorption.

Drug-Disease Interaction

Hemodialysis

During Hemodialysis penicillin antibiotics get removed from the body. So doses should be rescheduled after the dialysis process

Mononucleosis

Ampicillin should not be used in patients with mononucleosis because they develop pruritic erythematous maculopapular skin rash which occurs after 5-10 days of therapy

Colitis

Therapy should be administered with caution in patients who are having a history of gastrointestinal diseases like colitis, pseudomembranous colitis. Clostridioides dificile-associated diarrhea has been reported while using anti-bacterial drugs.

Renal dysfunction

The serum concentration of beta-lactam antibiotics increases the half-life in a patient with impaired renal functions. Depending upon your renal function dose should be adjusted

Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.

Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

• Stored at 10-30°C room temperature.
• Protect from light and heat.
• Keep away from children and pets. Otherwise, it becomes toxic to them.
• Disposed of properly in a suitable bag.

Synmega 250mg/125mg Tablet contains Ampicillin 250mg and Salbactum 125mg used to treat bacterial infections such as Gynecologic infections, Intra-Abdominal infections, Skin and skin structure infections, Orbital cellulitis, Pelvic inflammatory diseases, Pneumonia, and Urinary tract infections. Mainly this medicine targets the throat, ear, nasal sinuses, respiratory tract, urinary tract, skin, and soft tissue.

Ampicillin 250mg is the first-line antibiotic for a wide range of bacterial infections. It can cause interactions if having allergic penicillin drugs are in the past. It can be used in treating stomach ulcers along with a combination of other drugs, must be used in caution if having allergic to cephalosporins. Sulbactam 125mg is an antibiotic used to treat severe bacterial infections. Usually, it is prescribed in a combination with other antibiotics to prevent the infection and reduce the resistance against the antibiotics. The combination of this medicine helps to fight against the infection