Synthivan Tablet

Brand Name Synthivan Tablet
Salt Composition Atazanavir (300mg) + Ritonavir (100mg)
Strength 300mg + 100mg
Product Form Tablet
Storage Store at room temperature (10-30°C)
Category HIV
Country of Origin India
Manufacturer Cipla Ltd.
Manufacturer/Marketer AddressCipla Ltd, Cipla House, Peninsula Business Park, Ganpatrao, kadam Marag, Lower Parel, Mumbai-400013.India
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Synthivan Tablet, Atazanavir 300mg, Ritonavir 100mg, Price, Uses, Side Effects - Drugcarts watermark
M.R.P : Rs.3246.09       Price : Rs.2596.87

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    Medical Description of Synthivan Tablet

    Synthivan Tablet contains Atazanavir 300mg and Ritonavir 100mg. Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet is a combination antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) infection. Synthivan tablet acts as a protease inhibitor and CYP3A inhibitor. Synthivan tablet works by reducing the viral load of HIV in your body. Synthivan tablet improves your immune system and reduces the risk of conditions associated with HIV infection. It is used in children above 6 years old and in adults.


    Synthivan Tablet Uses

    Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet is used to treat adults and children above 6 years of age or above 35Kgs who are infected by HIV. Synthivan tablet contains Atazanavir which is a protease inhibitor that interferes with the multiplication of HIV particles and Ritonavir is also a potent CYP3A inhibitor. Thus, Synthivan tablet control and treat HIV-1 infection.


    Synthivan Tablet Benefits

    Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet is used to help control HIV infection. Synthivan tablet doesn’t cure It helps to decrease the amount of virions in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Synthivan tablet is not recommended for use in children less than 6 years due to the increased risk of serious side effects.


    Synthivan Tablet Indication

    Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet is indicated in the treatment of HIV infection that causes AIDS in humans. Synthivan tablet is indicated in ages above 6 years or patients who weigh more >35kgs


    Mechanism of action of Synthivan Tablet

    Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet is a HIV protease inhibitor. Protease inhibitors are used as a part of highly active antiviral therapy (HAART) in HIV-infected patients. Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet prevents HIV replication by binding to this specific enzyme thus selectively inhibits the cleavage of HIV-1 encoded Gag-Pol polyproteins in cells affected by the virus, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection.


    How Synthivan Tablet works

    Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet is a HIV protease inhibitor. Synthivan tablet binds to different sites on the enzyme namely the active site and the surface of one of the flexible flaps in the protease dimer on HIV-1. Synthivan prevents HIV replication by binding to this specific enzyme thus selectively inhibits the cleavage of HIV-1 encoded Gag-Pol polyproteins in cells affected by the virus, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection.


    Synthivan Tablet Contraindication

    Absolute contraindications:

    • if you are allergic to Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet
    • if you have severe liver problems like hepatitis B/C or hepatic insufficiency
    • if you are breastfeeding
    • if <6 yrs of age
    • if <35kgs

    Relative contraindication:

    • if you have kidney disease
    • if you are diabetic
    • if you have a bleeding disorder like haemophilia
    • if you have a lipid disorder like hyperlipidaemia
    • if you have heart diseases
    • if you are pregnant – this medication lowers the risk of passing HIV infection to the baby
    • if you are on any other medications


    Synthivan Tablet Side Effects

    Common side effects that occur 1:10 patients: headache, ocular icterus, vomiting, diarrhea, abdominal pain, nausea, dyspepsia, jaundice, rash, fatigue, flushing, dizziness, cough, tingling sensation or numbness in the hands, feet or around the lips and mouth, bad taste in the mouth, itching, rash, joint pain and back pain, anxiety, fever, seizure, weight loss.

    Uncommon side effects that occur 1:100 patients: hypersensitivity, weight decreased, weight gain, anorexia, appetite increased, depression, disorientation, anxiety, insomnia, sleep disorder, abnormal dream, peripheral neuropathy, syncope, amnesia, dizziness, hepatitis, cholelithiasis, cholestasis, erythema multiforme, toxic skin eruptions, DRESS, angioedema, urticaria, alopecia, pruritus,  muscle atrophy, arthralgia, myalgia, nephrolithiasis, haematuria, proteinuria, pollakiuria, interstitial nephritis, gynecomastia,  chest pain,

    Rare side effects that occur 1:1000 patients: gait disturbance, kidney pain, myopathy, Stevens-Johnson syndrome, toxic epidermal necrolysis, vesiculobullous rash, eczema, vasodilatation, hepatosplenomegaly, cholecystitis, QTc prolongation, edema, palpitation.


    FAQs for Synthivan Tablet

    Is Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet safe during pregnancy?

    This medication is not recommended in pregnancy unless the pros outweigh the cons. Consult your physician.

    Can Synthivan tablet be taken while breastfeeding?

    There is no specific study to detail this. But in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding. Thus, consult your physician.

    Can Synthivan tablet be taken while alcohol consumption?

    The interaction is unknown. Thus, consult your physician.

    Can I take painkillers with Synthivan tablet?

    The safest pain killer to be taken with Synthivan tablet is paracetamol but prolonged usage should be taken only when advised by the physician.

    Can I take health supplements with Synthivan tablet?

    Yes, most health supplements that contain calcium or iron can be taken. For precautious use kindly consult your physician.


    Precautions and general warning of Synthivan Tablet

    Alcohol

    Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet generally causes blurry vision, fainting, and movement disorders thus it is advised not to be taken with alcohol. For further queries, consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution as Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet causes fainting spells and movement disorders. For further queries, consult your physician.

    Pregnancy

    The use of Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet is cautiously used during pregnancy. In addition, it decreases the rate of HIV transmission to the fetus and decreases mortality rate. Thus, consult your physician.

    Breast Feeding

    The use of Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effect in newborn.

    Kidney Problem

    Renal calculus and renal filtration impairment – monitor function. For further queries, consult your physician.

    Liver Disease

    Inform your physician if you have hepatitis B or C or any history of gall stones or marked transaminase elevation because it could cause abnormal liver function. Thus, monitor with regular blood work.


    How to Take Synthivan Tablet

    Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet is taken orally with food.

    Swallow Synthivan tablet as a whole.

    Don’t chew, break or crush the tablet.

    After therapy has been initiated, do not take more or less of Synthivan than prescribed or stop taking it without your physicians’ approval. Skipping or changing Synthivan tablet dose without approval would increase the viral load making the infection more difficult to treat, or worsen side effects. For further queries consult your physician.


    Use of Synthivan Tablet in Adult

    If you are pregnant or breastfeeding inform your physician since pros and cons need to be discussed.

    The recommended dose of Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet is once tablet taken once daily and with food.

    Synthivan tablet must be taken with food and the medicine must be swallowed.


    Use of Synthivan Tablet in children

    Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet is used in children above age 6 who are not below 35kgs weight

    Synthivan tablet is taken once per day orally.

    Synthivan tablet should not be administered with Proton pump inhibitors or efavirenz.


    Use of Synthivan Tablet in Elderly Patients

    Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet has only been used in few patients 60 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Any sign of infection – fever or lymph node enlargement
    • Pancreatitis – discontinue treatment
    • Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
    • New onset or of diabetes mellitus, hyperglycemia
    • Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Accumulation or Redistribution of body fat or immune reconstitution syndrome.
    • Immune Reconstitution Syndrome
    • Haemophilia may develop increased bleeding events.


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have any kidney diseases

    If you have hypertension or any heart problem

    If you have any bleeding problem

    If you are pregnant or breastfeeding


    General instructions

    Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet must be taken orally at the prescribed dosage at a specific time regularly with food. If Synthivan tablet is taken separately or without food, the efficiency of medicine is reduced significantly, thus it is ill-advised.


    Drug Interaction of Synthivan Tablet

    Drug-Drug Interaction

    Decreased metabolism caused by Alfuzosin, Sildenafil

    Increased metabolism caused by Rifampin

    Increased Serum concentration caused by midazolam, Lovastatin, simvastatin

    Increased severity of side effects by Aceclofenac, Amphotericin B

    St. John’s wort (Hypericum perforatum)

    Drug-Food Interaction

    Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. Synthivan tablet generally causes blurry vision, fainting, and movement disorders thus it is advised not to be taken with alcohol.

    Drug-Disease Interaction

    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
    • Blood disorders – used with caution in anemia and thrombocytopenia. Consult a physician before use


    Over Dose

    Overdosing may cause breathing difficulty, dizziness, chest palpitations and numbness of extremities. The dosage considered at overdose in Synthivan is 1200mg taken once and 1500mg taken twice a day respectively. It causes renal failure with eosinophilia and heart block due to an increase in PR interval. Contact your doctor immediately.


    Missed Dose

    You can take the missed dosage if you notice within 12 hours. Always take Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet with food. If it is more than 12 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Store them away from heat and moisture Store at 25?C

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately


    Fast Tag

    Synthivan tablet contains Atazanavir 300mg and Ritonavir 100mg.

    Synthivan (Atazanavir (300mg) + Ritonavir (100mg)) tablet is a protease inhibitor.

    Synthivan tablet is used to control and treat HIV infection.

    Do not use this medication while pregnant and lactation period without caution. Consult your physician.

    Don’t use this medication with liver disease, kidney disease, and bleeding disorder. Consult your physician.

    This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury etc.