Tenolam Tablet

Brand Name Tenolam Tablet
Salt Composition Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)
Strength 300mg + 300mg
Product Form Tablet
Storage Store at room temperature (10-30°C)
Category HIV
Country of Origin India
-10%
Tenolam Tablet, Lamivudine 300mg, Tenofovir Disoproxil Fumarate 300mg, price, Uses, Side Effects - Drugcarts watermark
M.R.P : Rs.1279.75       Price : Rs.1151.78

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    Medical Description of Tenolam Tablet

    Tenolam contains Lamivudine 300mg and Tenofovir disoproxil fumarate 300mg. Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV)-1 infection. Tenolam tablet is a nucleoside analogue. Tenolam tablet acts on HIV reverse transcriptase thus interfere with their reproduction cycle.


    Tenolam Tablet Uses

    Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is used to treat adults and adolescence above 18 years of age who are infected by HIV. Tenolam tablet is used in caution with hepatitis B and renal impairment.


    Tenolam Tablet Benefits

    Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Tenolam tablet is not a cure for HIV infection, it improves immunity that results in longevity of life; thus, precautions are necessary while sexual intercourse, surgery etc. Tenolam tablet is safely used in adolescence above age 18 and adults


    Tenolam Tablet Indication

    Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is indicated in the treatment of HIV infection that causes AIDS in humans. Tenolam tablet is used to boost the immunity of the affected hosts by reducing the viral load of the infected cells. Prior to administration of Tenolam tablet screening for hepatitis B infection and renal impairment is noted. Tenolam tablet causes flare up of hepatitis B infection and end-stage renal failure. Tenolam tablet is indicated in ages above 18 years.


    Mechanism of action of Tenolam Tablet

    Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is a nucleoside analogue that acts as a reverse transcriptase inhibitor. Tenofovir disoproxil fumarate present in Tenolam tablet is an analogue of adenosine 5-monophosphate which is converted to tenofovir after hydrolysis after which tenofovir inhibits HIV-1 reverse transcriptase. Tenofovir competes with AMP as a substrate and competes to incorporate themselves into the DNA strand thus stops the replication of viral particles.  Lamivudine present in Tenolam tablet is an analogue that is phosphorylated to its active forms lamivudine triphosphate that incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.


    How Tenolam Tablet works

    Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is a nucleoside analogue that acts as reverse transcriptase inhibitor. The active substance of tenofovir disoproxil fumarate and lamivudine competes with AMP and incorporates themselves into DNA strand and thus replication process of viral particle is terminated. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.


    Tenolam Tablet Contraindication

    • if you are allergic to Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet and its contents
    • if you have a liver disease like hepatitis B or C or hepatomegaly with steatosis
    • if you have kidney impairment
    • if <18 years of age
    • if you are breastfeeding
    • if you are pregnant


    Tenolam Tablet Side Effects

    Common side effects that occur 1:10 patients: Headache, insomnia, Cough, Nausea, vomiting, abdominal pain or cramps, diarrhoea, Rash, alopecia, Arthralgia, Fatigue, malaise, fever, hypophosphataemia, asthenia

    Uncommon side effects that occur 1:100 patients: Neutropenia and anaemia, thrombocytopenia, hypokalaemia, proximal renal tubulopathy 

    Rare side effects that occur 1:1,000 patients: Pancreatitis, Hepatitis, Angioedema, hepatic steatosis, osteomalacia, acute renal failure, renal failure, acute tubular necrosis, nephritis 2, nephrogenic diabetes insipidus,  

    Very rare side effects that occur 1:10,000 patients: Pure red cell aplasia, Lactic acidosis, Peripheral neuropathy, Rhabdomyolysis


    FAQs for Tenolam Tablet

     

    Is Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet safe during pregnancy?

    This medication is used with caution in pregnancy when pros outweigh the cons. Consult your physician.

    Can Tenolam tablet be taken while breastfeeding?

    There is no specific study to detail this. But in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding. Thus, consult your physician.

    Can Tenolam tablet be taken while alcohol consumption?

    The interaction is unknown but this medication causes dizziness. Thus, consult your physician.

    Can I take drive or operate heavy machineries while on Tenolam tablet?

    This medication causes dizziness and instability thus caution is used while driving or operating machineries.

    Can Tenolam tablet be taken in case of hepatitis B?

    No, Tenolam tablet must be taken when diagnosed with hepatitis B as this medication may cause failure


    Precautions and general warning of Tenolam Tablet

    Alcohol

    Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution as Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet causes side effects. For further queries, consult your physician.

    Pregnancy

    Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is cautiously used during pregnancy as it may cause some side effects on the fetus. Thus, consult your physician.

    Breast Feeding

    The use of Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effects in newborn.

    Kidney Problem

    Inform your physician if you have compromised kidney function as Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet may cause renal disorders that results in end-stage kidney failure

    Liver Disease

    Inform your physician if you have hepatitis B or C


    Use of Tenolam Tablet in children

    Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is not recommended for ages below 18.


    Use of Tenolam Tablet in Elderly Patients

    Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Bone density loss
    • Pancreatitis
    • Lactic acidosis
    • Hepatic decompensation
    • Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
    • Accumulation or Redistribution of body fat
    • immune reconstitution syndrome.


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have any kidney diseases

    If you have blood disorders

    If you are pregnant or breastfeeding


    General instructions

    Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is taken at a specific time regularly with food. If Tenolam tablet is taken without food the efficiency of medicine is reduced significantly, thus it is ill-advised.


    Drug Interaction of Tenolam Tablet

    Drug-Drug Interaction

    Side effects are increased by Amphotericin B, acyclovir, amikacin

    Serum concentration is decreased by Acetazolamide, carbamazepine, Potassium citrate

    Serum concentration is increased by Carvedilol, clomifene, acetaminophen, Aceclofenac

    Drug-Food Interaction

    Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. Tenolam tablet generally causes dizziness and instability thus it is advised not to be taken with alcohol.


    Over Dose

    Symptoms of overdose include dizziness, palpitations etc. Contact your doctor immediately.


    Missed Dose

    You can take the missed dosage if you notice within 12 hours if you take them once a day. If it is more than 12 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Store them at <30?C

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately


    Fast Tag

    Tenolam (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is a nucleotide reverse transcriptase inhibitor

    It is used to control and treat HIV infection

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease and kidney disease.

    This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury, etc.