Tofashine 5mg Tablet

Brand Name Tofashine 5mg Tablet
Salt Composition Tofacitinib (5mg)
Strength 5mg
Product Form Tablet
Pack 10 Tablet(s) in strip
Storage Store at room temperature (10-30°C)
Category Arthritis
Country of Origin India
Manufacturer Sun Pharmaceutical Industries Limited
Manufacturer/Marketer AddressSun Pharmaceutical Industries Limited Acme Plaza, Andheri Kurla Road, Andheri (East), Mumbai, 400059 India
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M.R.P : Rs.350.00       Price : Rs.280.00

You Save : Rs.70.00    Inclusive of all taxes

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10 Tablet(s) in strip

Availability : In Stock

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    Medical Description of Tofashine 5mg Tablet

    Tofashine (Tofacitinib (5mg)) tablet is a class of medication called immunomodulators which are intended for oral use only. Tofashine tablet is used to treat Rheumatoid arthritis, Psoriatic arthritis, and ulcerative colitis by inhibiting the action of the enzyme, Janus Kinase and helps to reduces the inflammation, pain, tenderness, and swelling in the joints.


    Tofashine 5mg Tablet Uses

    Tofashine (Tofacitinib (5mg)) tablet is used to treat

    • Rheumatoid arthritis
    • Psoriatic arthritis
    • Ulcerative colitis


    Tofashine 5mg Tablet Benefits

    Tofashine (Tofacitinib (5mg)) tablet is used in the treatment for the following condition such as

    Rheumatoid arthritis:

    It is a chronic inflammatory disorder this will mainly affect joints in the hands and feet. Here our body's immune system attacks its healthy tissue including joints. Symptoms include tender, warm and swollen joints, joint stiffness and fatigue, fever, and loss of appetite.

    Psoriatic arthritis:

    It is a type of inflammatory arthritis that usually occurs in a patient who already has a skin condition called psoriasis. It is an autoimmune condition it occurs when your body’s immune system mistakenly attacks your healthy tissues. Symptoms include swollen fingers and toes, foot pain, lower back pain, fatigue, stiffness and tiredness in the morning, scaly skin on your knees, elbows, and scalp.

    Ulcerative colitis:

    It is an inflammatory bowel disease that causes irritation and ulcers in the digestive tract. It affects the innermost lining of your large intestine and rectum. Symptoms include diarrhea with blood and pus, abdominal pain and cramping, rectal pain, rectal bleeding, weight loss, fatigue, and fever.


    Tofashine 5mg Tablet Indication

    Tofashine (Tofacitinib (5mg)) tablet is a Janus Kinase inhibitor that produces its action by inhibiting the action of the enzyme, Janus Kinase and helps to reduce the inflammation, pain, tenderness, and swelling in the joints.  


    Mechanism of action of Tofashine 5mg Tablet

    Tofashine (Tofacitinib (5mg)) tablet is a Janus kinases inhibitor, it modulates a signaling pathway that influences the cellular processes of hematopoiesis and immune cell function. Signals in this pathway arise from cytokines on the cellular membrane. Inhibition of Janus kinases prevents the phosphorylation and activation of signal transducers and activators of transcription, which modulates gene expression and other intracellular activity.


    How Tofashine 5mg Tablet works

    Tofashine (Tofacitinib (5mg)) tablet is a Janus Kinase inhibitor that produces its action by inhibiting the action of the enzyme, Janus Kinase and helps to reduce the inflammation, pain, tenderness, and swelling in the joints.


    Tofashine 5mg Tablet Contraindication

    If you are allergic to the composition of the medicines

    Abatacept + Tofacitinib

    The combination of this drug either increases the toxicity of the others by immunosuppressive effects. Use alternative drugs because the use of this drug may increase the risk of infections.

    Atazanavir + Tofacitinib

    Atazanavir increases the level of tofacitinib by affecting hepatic and intestinal enzyme metabolism. Use alternative drugs.

    Cimetidine + Tofacitinib

    Cimetidine increases the level of tofacitinib by decreasing its metabolism. Use alternative drugs.

    Deferiprone + Tofacitinib

    The combination of this drug either increases the toxicity of the others by pharmacodynamic synergism. Use alternative drugs because the use of this drug may increase the risk of neutropenia and agranulocytosis.

    Fluconazole + Tofacitinib

    Therapy should be administered with caution because the use of fluconazole increases the effect of tofacitinib by affecting its hepatic enzyme metabolism.


    Tofashine 5mg Tablet Side Effects

    • Infection
    • Diarrhea
    • Nasopharyngitis
    • Hypertension
    • Malignancies
    • Anemia


    FAQs for Tofashine 5mg Tablet

    Can I take a Tofashine (Tofacitinib (5mg)) tablet if I have liver problems?

    Before initiating the treatment inform your doctor if you have liver problems. Because the tablet can be given to patients with mild to moderate liver problems, but it should be given to patients with severe hepatic impairment.

    Can Tofashine tablet cause cancer?

    The use of this tablet may increase the chances of developing certain cancers by affecting the immune system. Kindly inform your doctor before initiating the treatment.

    What is the Tofashine tablet used for?

    Tofashine tablet is in a class of medication called immunomodulators which are intended for oral use only. Tofashine tablet is used to treat Rheumatoid arthritis, Psoriatic arthritis, and ulcerative colitis by inhibiting the action of the enzyme, Janus Kinase and helps to reduces the inflammation, pain, tenderness, and swelling in the joints.

    How long does it take for the Tofashine tablet to start working?

    Tofashine tablet usually takes about 2 to 8 weeks to start feeling better, and it takes 3 to 6 months to feel the maximum effect of this medication.


    Precautions and general warning of Tofashine 5mg Tablet

    Alcohol

    Tofashine (Tofacitinib (5mg)) tablet is not known that consuming alcohol may affect the drug. Kindly consult with your doctor

    Driving or operating machinery

    Tofashine (Tofacitinib (5mg)) tablet is considered safe during driving and it does not affect your ability to drive. Kindly consult with your doctor

    Pregnancy

    Tofashine (Tofacitinib (5mg)) tablet is considered unsafe during pregnancy it may cause harmful effects to the fetus. Kindly consult with your doctor.

    Breast Feeding

    Tofashine (Tofacitinib (5mg)) tablet is considered unsafe during breastfeeding it may excrete via breast milk. Kindly consult with your doctor.

    Kidney Problem

    Use caution to the patient who is having a renal impairment. Kindly consult with your doctor. Closely monitor the patient renal function

    Liver Disease

    Use caution to the patients who are having cardiovascular diseases. Kindly consult with your doctor


    How to Take Tofashine 5mg Tablet

    Tofashine (Tofacitinib (5mg)) tablet is taken orally by mouth twice daily with or without food. The extended-release tablet is usually taken once daily with or without food. Do not chew, crush or break the tablet. Follow the direction mentioned in the label if you did not understand the application kindly ask your doctor or pharmacist to explain the details. Do not discontinue the medicine when you feel better kindly consult with your doctor. Tofacitinib controls the condition but does not cure it.


    Use of Tofashine 5mg Tablet in Adult

    Consult your doctor.


    Use of Tofashine 5mg Tablet in children

    Tofashine (Tofacitinib (5mg)) tablet is considered unsafe to use this medicine in children. kindly consult with your doctor.


    Use of Tofashine 5mg Tablet in Elderly Patients

    Tofashine (Tofacitinib (5mg)) tablet is considered safe to an elderly patient if the medicine is prescribed by your doctor


    Other general warnings

    • The use of this drug may increase the risk of malignancy, lymphoproliferative disorders, GI perforation, viral reactivation, diverticulitis, and non-melanoma skin cancers was reported.
    • The use of this drug gradually decrease the lymphocyte and neutrophils counts
    • The use of this drug increases the liver function tests, lipid parameters including total cholesterol, LDL, and HDL.
    • It is not recommended to use this drug in patients with severe hepatic impairment
    • Therapy should be administered with caution in a patient with a history of lung diseases, chronic infection, and tuberculosis.


    Talk to your doctor if

    If you are allergic to the composition of the tablet

    If you are using any concomitant medications

    If you are not responding to the treatment


    General instructions

    Consult with your doctor


    Drug Interaction of Tofashine 5mg Tablet

    Drug-Drug Interaction

    Abatacept + Tofacitinib

    The combination of this drug either increases the toxicity of the others by immunosuppressive effects. Use alternative drugs because the use of this drug may increase the risk of infections.

    Atazanavir + Tofacitinib

    Atazanavir increases the level of tofacitinib by affecting hepatic and intestinal enzyme metabolism. Use alternative drugs.

    Cimetidine + Tofacitinib

    Cimetidine increases the level of tofacitinib by decreasing its metabolism. Use alternative drugs.

    Deferiprone + Tofacitinib

    The combination of this drug either increases the toxicity of the others by pharmacodynamic synergism. Use alternative drugs because the use of this drug may increase the risk of neutropenia and agranulocytosis.

    Fluconazole + Tofacitinib

    Therapy should be administered with caution because the use of fluconazole increases the effect of tofacitinib by affecting its hepatic enzyme metabolism.

    Drug-Food Interaction

    No information is available kindly consult with your doctor

    Drug-Disease Interaction

    Viral reactivation:

    The use of Tofashine tablet has been associated with viral reactivation including herpes viral reactivation. Before initiating the therapy it is recommended to screen for the reoccurrence of viral hepatitis.

    GI perforation:

    Therapy should be administered with caution in patients with an increased risk of gastrointestinal perforation.  Patients who are with new onset of abdominal symptoms should be evaluated for early identification of gastrointestinal perforation.

    Hepatic disorder:

    Tofashine tablet has not been studied in a patient with severe hepatic impairment and the use of tofacitinib has been associated with an increased risk of liver enzyme elevation. So it is recommended in patients with hepatic impairment. Routine monitoring of liver function tests is recommended.

    Infections:

    Serious bacterial, mycobacterial, invasive fungal, viral and other opportunistic infections have been reported in patients who are all receiving tofacitinib. Before initiating the treatment it is recommended to avoid the use of tofacitinib in patients with an active and serious infection. Closely monitor the patient for the development of signs and symptoms of infection during and after treatment.

    Renal disease:

    Patients with moderate and severe renal impairment had greater tofacitinib blood levels so the recommended dose of tofacitinib is 5 mg once daily. No dose adjustment of tofacitinib is necessary for patients with mild renal impairment.


    Over Dose

    Consuming more tablets than the prescribed dose may lead to overdose. Kindly use the medicine as per your doctor advice


    Missed Dose

    If you missed the dose take it as soon as you remember. If it is time for the next dose skip the missed dose and continue with a regular dose


    Storage and Disposal

    Store the medicine in a closed container at room temperature, away from heat, moisture, and direct sunlight

    Keep out of the reach of children

    Do not keep outdated medicine

    Ask your doctor or pharmacist how to  dispose of medicine that is not in use

    Store below 30°C


    Fast Tag

    Tofashine (Tofacitinib (5mg)) tablet is a Janus Kinase inhibitor

    Tofashine tablet is used to treat rheumatoid arthritis, Psoriatic arthritis, and ulcerative colitis

    Tofashine tablet is taken orally by mouth twice daily with or without food.  The extended-release tablet is usually taken once daily with or without food.

    Do not use this medicine if you are allergic to the composition of the tablet