Tofocom Tablet

Brand Name Tofocom Tablet
Salt Composition

Emtricitabine (200mg) + Tenofovir disoproxil fumarate (300mg)

Strength 300mg + 200mg
Product Form Tablet
Pack 30 Tablet(s) in Bottle
Storage Store below 30°C
Category

HIV

SubCategory

HIV

Country of Origin India
Manufacturer

Alkem Laboratories Limited

Manufacturer/Marketer Address Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
-22.5%
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M.R.P : Rs.1971.42       Price : Rs.1527.85

You Save : Rs.443.57    Inclusive of all taxes

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30 Tablet(s) in Bottle

Availability : In Stock


    Medical Description of Tofocom Tablet

    Tofocom tablet contains Tenofovir disoproxil fumarate 300mg and Emtricitabine 200mg. Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV)-1 infection. Tofocom tablet is a nucleotide reverse transcriptase inhibitor. Tofocom tablet acts on HIV reverse transcriptase enzyme thus interfere with their reproduction cycle.


    Tofocom Tablet Uses

    Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet is used to treat adults and adolescence above 18 years of age who are infected by HIV. Tofocom tablet is used in caution with liver and renal impairment patients.


    Tofocom Tablet Benefits

    Tofocom (Tenofovir disoproxil fumarate 300 mg + Emtricitabine 200 mg) is used with other anti-HIV medication to help control HIV infection. Tofocom tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Tofocom tablet is not a cure for HIV infection, it improves immunity that results in longevity of life; thus, precautions are necessary while sexual intercourse, surgery etc. Tofocom tablet is safely used in adolescence above 35 kgs of weight. Tofocom tablet is used as a pre prophylactic to exposure in a previously negative HIV test.


    Tofocom Tablet Indication

    Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet is indicated in the treatment of HIV infection that causes AIDS in humans. Tofocom tablet is used with other antiviral medications to boost immunity of the affected hosts by reducing the viral load of the infected cells. Tofocom tablet is safely used in adolescence above 35 kgs of weight. Tofocom tablet is used as a pre prophylactic to exposure in a previously negative HIV test.


    Mechanism of action of Tofocom Tablet

    Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet is a nucleotide reverse transcriptase inhibitor. Tenofovir disoproxil fumarate present in Tofocom tablet is an analogue of adenosine 5-monophosphate which is converted to tenofovir after hydrolysis after which tenofovir inhibits HIV-1 reverse transcriptase and HBV reverse transcriptase. Tenofovir competes with AMP as a substrate and competes to incorporate themselves into the DNA strand thus stops the replication of viral particles. Emtricitabine present in Tofocom tablet is an analogue of cytidine is phosphorylated to its active form. Emtricitabine 5 triphosphate inhibits the activity of HIV-1 reverse transcriptase and incorporates themselves into the DNA thus results in the termination of replication process. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped by the use of Tofocom tablet.


    How Tofocom Tablet works

    Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet competes with AMP and cytidine respectively and incorporates themselves into DNA strand and thus replication process of viral particle is terminated. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.


    Tofocom Tablet Contraindication

    • if you are a positive HIV case
    • if you are allergic to Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet and its combinate
    • if you have liver disease like hepatitis B or C or hepatomegaly with steatosis
    • if you have kidney impairment
    • if <35 kgs of weight
    • if you are breastfeeding 


    Tofocom Tablet Side Effects

    Common side effects that occur 1:10 patients: diarrhea, nausea, fatigue, headache, dizziness, depression, insomnia, abnormal dreams, and rash

    Rare side effects that occur 1:1,000 patients: hepatomegaly, worsening hepatitis B infection, decreased bone density,

    Very rare side effects that occur 1:10,000 patients: lactic acidosis, immune reconstitution syndrome, Interstitial Nephritis, peripheral neuropathy, Fanconi syndrome, renal tubular necrosis, inflammatory hepatitis, angioedema


    FAQs for Tofocom Tablet

    Is Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet safe during pregnancy?

    This medication is not recommended in pregnancy unless pros outweigh the cons. Consult your physician.

    Can Tofocom tablet be taken while breastfeeding?

    There is no specific study to detail this. But in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding. Thus, consult your physician.

    Can Tofocom tablet be taken while alcohol consumption?

    The interaction is unknown but this medication causes dizziness. Thus, consult your physician.

    Can I take drive or operate heavy machineries while on Tofocom tablet?

    This medication causes dizziness and instability thus caution is used while driving or operating machineries.

    Can Tofocom tablet be taken as a prophylactic?

    Yes, only if you are tested negative immediately after exposure. Please consult a physician before use.


    Precautions and general warning of Tofocom Tablet

    Alcohol

    Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution as Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet causes side effects. For further queries, consult your physician.

    Pregnancy

    Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet is cautiously used during pregnancy as it may cause some side effects on the fetus. Thus, consult your physician.

    Breast Feeding

    The use of Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effect in newborn.

    Kidney Problem

    Inform your physician if you have compromised kidney function as Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet may cause renal disorders that results in end-stage kidney failure

    Liver Disease

    Inform your physician if you have hepatitis B or C

    Hepatomegaly with steatosis


    Use of Tofocom Tablet in children

    The recommended dosage of Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet in single dose taken once per day orally with or without food


    Use of Tofocom Tablet in Elderly Patients

    Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Bone density loss
    • Pancreatitis
    • Lactic acidosis
    • Hepatic decompensation
    • Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
    • Accumulation or Redistribution of body fat
    • immune reconstitution syndrome.


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have any kidney diseases

    If you are pregnant or breastfeeding


    General instructions

    Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet is taken at specific time regularly with food. If Tofocom tablet is taken without food the efficiency of medicine is reduced significantly, thus it is ill advised.


    Drug Interaction of Tofocom Tablet

    Drug-Drug Interaction

    Atazanavir/Acyclovir/Amikacin/Amphotericin B

    Carbamazepine/Clarithromycin

    Didanosine/Deferoxime/

    Probenecid/Phenobarbital/Phenytoin

    Ibuprofen

    Ketorolac/Ketoconazole

    Mefenamic acid/ Methadone

    Naproxen

    Fluconazole

    Rifampin

    Drug-Food Interaction

    Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. Tofocom tablet generally causes known side-effects thus it is advised not to be taken with alcohol.


    Over Dose

    Symptoms of overdose include dizziness, palpitations etc. Contact your doctor immediately.


    Missed Dose

    You can take the missed dosage if you notice within 12 hours if you take them once a day. If it is more than 12 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Store them at <30°C

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately


    Fast Tag

    Tofocom (Tenofovir disoproxil fumarate (300mg) + Emtricitabine (200mg)) tablet is a nucleotide reverse transcriptase inhibitor

    It is used to control and treat HIV infection

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease and kidney disease.

    Do not use this medication as a prophylactic, consult a physician before use

    This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury etc.