Virem R Tablet

Brand Name Virem R Tablet
Salt Composition Darunavir (600mg) + Ritonavir (100mg)
Strength 600mg + 100mg
Product Form Tablet
Pack 60 Tablet(s) in Bottle
Storage Store at room temperature (10-30°C)
Category HIV
Country of Origin India
Manufacturer Emcure Pharmaceuticals Ltd
Manufacturer/Marketer AddressEmcure Pharmaceuticals Ltd, 255/2, Hinjawadi, Pune - 411057, India.
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Virem R Tablet, Darunavir 600mg, Ritonavir 100mg, price, Uses, Side Effects - Drugcarts watermark
M.R.P : Rs.7000.00       Price : Rs.5600.00

You Save : Rs.1,400.00    Inclusive of all taxes

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Availability : In Stock


    Medical Description of Virem R Tablet

    Darunavir 600mg+Ritonavir 100mg  contains two drugs namely darunavir 600mg and ritonavir 100mg. Darunavir 600mg+Ritonavir 100mg  is an antiretroviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection in adults. Darunavir 600mg+Ritonavir 100mg

    acts as a protease inhibitorthat interferes with the reproductive cycle of HIV thus reduces the viral load of HIV in your body. Ritonavir50mg  is a potent CYP3A inhibitor that increases plasma drug concentrations of other protease inhibitors. The drug is used in combination with other antiretrovirals to control and treat HIV-1 infection.


    Virem R Tablet Uses

    Darunavir 600mg+Ritonavir 100mg  is used to treat adults and children above 3 years of age or if weight is more than 15Kg who are infected by HIV-1. Darunavir 600mg+Ritonavir 100mg  is a protease inhibitor that interferes with the multiplication of HIV particles.


    Virem R Tablet Benefits

    Darunavir 600mg+Ritonavir 100mg  decreases the amount of HIV in your body , thus your immunityworks better by reducing your chance of getting HIV complications like co-infections and other cancers.Darunavir 600mg+Ritonavir 100mg  is a protease inhibitor that interfers with the reproduction cycle of HIV.Darunavir 600mg+Ritonavir 100mg  is not a cure for HIV infection, it improves immunity that results in longevity of life.


    Virem R Tablet Indication

    Darunavir 600mg+Ritonavir 100mg  is indicated in case of HIV-1 infection that causes AIDS in humans.Darunavir 600mg+Ritonavir 100mg  is used with together to boost immunity of the affected hosts. Darunavir 600mg+Ritonavir 100mg  is indicated in ages above 3 years or above 15kgs of body weight.


    Mechanism of action of Virem R Tablet

    Darunavir 600mg+Ritonavir 100mg  is HIV-1 protease inhibitor. Protease inhibitors are used as a part of highly active antiretroviral therapy (HAART) in HIV infected patients. Darunavir 600mg+Ritonavir 100mg prevents HIV replication by binding to this specific enzyme thus selectively inhibits the cleavage of HIV-1 encoded Gag-Pol polyproteinsprecursors of HIV-1 protease in cells affected by the virus, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection.


    How Virem R Tablet works

    Darunavir 600mg+Ritonavir 100mg  is HIV-1 protease inhibitor. Darunavir 600mg+Ritonavir 100mg  binds to different sites on the enzyme namely the active site and the surface of one of the flexible flaps in the protease dimer. Darunavir 600mg+Ritonavir 100mg prevents HIV replication by binding to this specific enzyme thus selectively inhibits the cleavage of HIV-1 encoded Gag-Pol polyproteins in cells affected by the virus, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection.


    Virem R Tablet Contraindication

    Absolute contraindicationsofDarunavir 600mg+Ritonavir 100mg :

    • if you are allergic to darunavir or ritonavir- toxic epidermal necrolysis (TEN) or Stevens-Johnson syndrome
    • if you have severe liver problems like hepatitis B or C
    • if you have any bleeding disorders like haemophilia

    Relative contraindicationof Darunavir 600mg+Ritonavir 100mg tab:

    • if you are diabetic
    • if you have lipid disorder like hyperlipidaemia
    • if you have heart diseases
    • if you are pregnant – this medication lowers the risk of passing HIV infection to the baby
    • if you have kidney disease


    Virem R Tablet Side Effects

    Common side effects that occur 1:10 patients: diarrhoea, vomiting, nausea, abdominal pain or distension, dyspepsia, flatulence, flushing, headache, tiredness, dizziness, fatigue, swelling of the face or lymph glands, increase of eosinophils, drowsiness, numbness, tingling or pain in hands or feet, loss of strength,itching, rash, difficulty falling asleep.

     

    Uncommon side effects that occur 1:100 patients: chest pain, rapid heart rate, decrease in skin sensitivity, pins and needles, loss of memory, problems with balance, difficulty breathing, cough, nosebleed, heartburn, retching, dry mouth, constipation, belching, kidney stones, frequent or excessive passage of urine, urticaria, severe swelling of the skin around lips or eyes, eczema, excessive sweating, hair loss, acne, scaly skin, colouration of nails, muscle pain, muscle cramps or weakness, osteoporosis, high blood pressure, flushing, red or dry eyes, fever, swelling of lower limbs due to fluids, malaise, irritability, erectile dysfunction, decrease in sexual drive, enlargement of breasts, sleeping problems.

     

    Rare side effects that occur 1:1000 patients: a reaction called DRESS [severe rash, accompanied by fever, , effects on liver, kidney or lung], severe or life-threatening skin reaction including blisters like Stevens Johnson syndrome, toxic epidermal necrolysis, anaphylaxis heart attack, slow heart beating, visual disturbance, chills, altered mood, fainting, epileptic fits, changes or loss of taste, mouth sores, vomiting blood, skin lesions, dry skin, stiffness of muscles or joints, joint pain with or without inflammation, changes in blood chemistry, changes in urine chemistry

     


    FAQs for Virem R Tablet

    • IsDarunavir 600mg+Ritonavir 100mg ) safe during pregnancy?

    Yes, taking Darunavir 600mg+Ritonavir 100mg  during pregnancy is safe and this significantly reduces the rate of the viral load transmitted to the fetus.

    • CanDarunavir 600mg+Ritonavir 100mg be taken while breast feeding?

     Consult your physician

    What is the most common side effect ofDarunavir 600mg+Ritonavir 100mg )?

    Diarrhea is the most common side effect caused byDarunavir 600mg+Ritonavir 100mg

    and this can be treated by taking plenty of fluids.

    • Can I take Darunavir 600mg+Ritonavir 100mg with alcohol?

    Darunavir 600mg+Ritonavir 100mg is not advised to be taken with alcohol. For queries talk to your physician

    Can I drive or operate heavy machinery while onDarunavir 600mg+Ritonavir 100mg?

    It is not advisable to drive or operate heavy machinery while onDarunavir 600mg+Ritonavir 100mg.For queries talk to your physician


    Precautions and general warning of Virem R Tablet

    Alcohol

    Darunavir 600mg+Ritonavir 100mg generally causes blurry vision, fainting, and movement disorders thus it is advised not to be taken with alcohol.For further queries, consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution asDarunavir 600mg+Ritonavir 100mg  causes fainting spells and movement disorders. For further queries, consult your physician.

    Pregnancy

    The use of Darunavir 600mg+Ritonavir 100mg is well tolerated during pregnancy. In addition, it decreases the rate of HIV transmission to the fetus and decreases mortality rate.

    Breast Feeding

    Consult your doctor

    Kidney Problem

    Monitor renal function. For further queries, consult your physician.

    Liver Disease

    In patients with hepatitis B or C or marked transaminase elevation caution is recommended as Darunavir 600mg+Ritonavir 100mg may cause hepatotoxicity and lead to death. Thus, monitor liver function before and during therapy.


    Use of Virem R Tablet in children

    Darunavir 600mg+Ritonavir 100mg has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Use of Virem R Tablet in Elderly Patients

    Darunavir 600mg+Ritonavir 100mg has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Drug interactions
    • Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis. In mild cases, additional medications are prescribed to control the spread of infection. DiscontinueDarunavir 600mg+Ritonavir 100mg, if a severe reaction develops.
    • Pancreatitis – discontinue treatment
    • Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
    • New onset diabetes mellitus or hyperglycemia – Monitor blood glucose and insulin levels. When needed add oral hypoglycemic and insulin
    • Accumulation or Redistribution of body fat or immune reconstitution syndrome.
    • Known case of sulfonamide allergy.
    • Hemophilia may develop increased bleeding events.
    • Immune Reconstitution Syndrome
    • Any sign of infection – fever or lymph node enlargement
    • Avoid in case of patients below 3 years of age


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have hypertension or any heart problem

    If you have any bleeding problem

    If you are pregnant or breastfeeding


    General instructions

    Darunavir 600mg+Ritonavir 100mg is taken with ritonavir orally as prescribed dosage at specific time regularly with food.


    Drug Interaction of Virem R Tablet

    Drug-Drug Interaction

    Amiodarone

    Alfuzosin

    Midazolam

    Colchicine

    Cisapride

    Ergot alkaloids

    Lovastatin

    Lurasidone

    Rifampicin

    Lopinavir

    Lovastatin

    Lomitapide

    Ritonavir

    Ranolazine

    Sildenafil

    Domperidone

    Quinidine

    Voriconazole


    Over Dose

    Contact your doctor immediately


    Missed Dose

    You can take the missed dosage of Darunavir 600mg+Ritonavir 100mg if you notice within 6 hours. Always Darunavir 600mg+Ritonavir 100mg with food. If it is more than 6 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.

     


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 25?C


    Fast Tag

    Darunavir 600mg+Ritonavir 100mg) contains two drugs namely darunavir 600mg and ritonavir 100mg. Darunavir 600mg+Ritonavir 100mg is an antiretroviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection in adults. Darunavir 600mg+Ritonavir 100mg acts as a protease inhibitorthat interferes with the reproductive cycle of HIV thus reduces the viral load of HIV in your body. Ritonavir50mg  is a potent CYP3A inhibitor that increases plasma drug concentrations of other protease inhibitors. The drug is used in combination with other antiretrovirals to control and treat HIV-1 infection.