Viropil Tablet 30s Pack

Brand Name Viropil Tablet 30s Pack
Salt Composition Dolutegravir (50mg) + Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)
Strength 50mg + 300mg + 300mg
Product Form Tablet
Category HIV
Country of Origin India
Manufacturer Emcure Pharmaceuticals Ltd
Manufacturer/Marketer AddressEmcure Pharmaceuticals Ltd, 255/2, Hinjawadi, Pune - 411057, India.
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Viropil Tablet, Tenofovir Disoproxil Fumarte 300mg, Dolutegravir 50mg, Lamivudine 300mg, Price, Uses, Side Effects - Drugcarts watermark
M.R.P : Rs.4121.00       Price : Rs.3296.80

You Save : Rs.824.20    Inclusive of all taxes

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Availability : In Stock


    Medical Description of Viropil Tablet 30s Pack

    Viropil Tablet contains Dolutegravir 50mg, Lamivudine 300mg and Tenofovir disoproxil fumarate 300mg. Viropil tablet (Dolutegravir (50mg) + Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg))  is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection. Dolutegravir is an integrase strand transfer inhibitor. Emtricitabine and Tenofovir Lamivudine and Tenofovir disoproxil fumarate present in is a nucleoside analogue. Viropil tablet works by reducing the viral load of HIV in your body. Viropil tablet improves your immune system and reduces the risk of conditions associated with HIV infection. 


    Viropil Tablet 30s Pack Uses

    Viropil tablet is used to treat adults and children above the weight class 35kg only who are infected by HIV-1.


    Viropil Tablet 30s Pack Benefits

    Viropil tablet is used to help control HIV infection. It helps to decrease the amount of HIV in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. It is not a cure for HIV infection, it improves immunity that results in longevity of life. It is recommended for use in children from 35kgs and in adults.


    Viropil Tablet 30s Pack Indication

    Viropil tablet is indicated in the treatment of HIV-1 infection that causes AIDS in humans.It boosts the immunity of the affected hosts. Viropil tablet is indicated in adults and children above 35kgs.


    Mechanism of action of Viropil Tablet 30s Pack

    Viropil Tablet contains Dolutegravir 50mg, Lamivudine 300mg and Tenofovir disoproxil fumarate 300mg. Dolutegravir is a inhibits strand transfer activity of integrase in DNA thus blocks replication of HV-1. Lamivudine is an analogue that is phosphorylated to its active forms lamivudine triphosphate that is incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Tenofovir disoproxil fumarate is an analogue of adenosine 5-monophosphate which is converted to tenofovir after hydrolysis after which tenofovir inhibits HIV-1 reverse transcriptase. Tenofovir competes with AMP as a substrate and competes to incorporate themselves into the DNA strand thus stops the replication of viral particles. Thus, the active HIV molecules become inactive and further reproduction and multiplication process is stopped.


    How Viropil Tablet 30s Pack works

    Viropil tablet contains an integrase inhibitor and nucleoside reverse transcriptase inhibitor. Dolutegravir inhibits the transfer of integrase in DNA and Lamivudine and tenofovir incorporates themselves into the DNA thus stops the replication of viral particles. Thereby preventing the formation of mature virus particles into infectious virions that spreads the infection.


    Viropil Tablet 30s Pack Contraindication

    Absolute contraindication:

    • if you are allergic to Viropil (Dolutegravir (50mg) + Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet and its contents
    • if you are pregnant
    • if you are breastfeeding

    relative contraindication:

    • if you have kidney disease
    • if you have a liver disease like hepatitis B or C
    • if you are diabetic
    • if you have a bleeding disorder like haemophilia
    • if you have heart diseases


    Viropil Tablet 30s Pack Side Effects

    Very common side effect that occur more than 1:10 patients: headache, diarrhoea, nausea,

    Common side effects that occur 1:10 patients: rash, pruritus, vomiting, abdominal pain, flatulence, insomnia, abnormal dreams, depression dizziness, tiredness, changes in LFT and increased creatine kinase, insomnia, Cough, vomiting, abdominal pain or cramps, Rash, alopecia, Arthralgia, Fatigue, malaise, fever, hypophosphataemia, asthenia

    Uncommon side effects that occur 1:100 patients: hepatitis, suicidal thoughts and behaviours, joint and muscle pain, Neutropenia and anaemia, thrombocytopenia, hypokalaemia, proximal renal tubulopathy 

    Rare side effects that occur 1:1000 patients: osteonecrosis, Pure red cell aplasia, Lactic acidosis, Peripheral neuropathy, Rhabdomyolysis


    FAQs for Viropil Tablet 30s Pack

    Is Viropil (Dolutegravir (50mg) + Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet safe during pregnancy?

    No, Viropil tablet is not safe during pregnancy. Consult your physician.

    Can a Viropil tablet be taken while breastfeeding?

    No, in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding.

    Can Viropil tablet be taken while alcohol consumption?

    The interaction is unknown but this medication causes side effects. Thus, consult your physician.

    Can I take a drive or operate heavy machineries while on a Viropil tablet?

    This medication causes side effects thus caution is used while driving or operating machineries.

    Can a Viropil tablet be taken as a prophylactic to exposure?

    No, Viropil tablet cannot be taken as a prophylactic.


    Precautions and general warning of Viropil Tablet 30s Pack

    Alcohol

    Viropil tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution as Viropil tablet causes side effects. For further queries, consult your physician.

    Pregnancy

    The use of Viropil tablet is not recommended during pregnancy.

    Breast Feeding

    The use of a Viropil  tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause an adverse effects in newborn.

    Kidney Problem

    Renal filtration impairment and kidney stone formation – monitor function. For further queries, consult your physician.

    Liver Disease

    Liver disorders and diseases like hepatitis B or C, Child-Pugh disease

    Monitor liver function before and during therapy, especially in patients with other


    How to Take Viropil Tablet 30s Pack

    Viropil tablet is taken with food at the regular time.

    Viropil tablet should not be crushed or chewed it must be swallowed.

    After therapy has been initiated, do not take more or less of Viropil than prescribed or stop taking it without your physicians’ approval. Skipping or changing Viropil tablet dose without approval may cause the amount of the virus to increase making the infection more difficult to treat, or worsen side effects.


    Use of Viropil Tablet 30s Pack in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.

    The recommended dosage for Viropil tablet is one tablet taken once per day

    These medicines must be taken with food on a regular time basis.


    Use of Viropil Tablet 30s Pack in children

    The recommended dosage of Viropil tablet above this weight class is one tablet taken once per day.


    Use of Viropil Tablet 30s Pack in Elderly Patients

    Viropil  tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • New onset diabetes mellitus or hyperglycemia – Monitor blood glucose and insulin levels. When needed add oral hypoglycemic and insulin
    • Blood disorders Hemophilia, hemolytic anemia
    • Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
    • Accumulation or Redistribution of body fat or
    • immune reconstitution syndrome.
    • Any sign of infection – fever or lymph node enlargement
    • Lactose intolerance or galactose malabsorption


    Talk to your doctor if

    If you have any allergy

    If you have a blood disorder

    If you are pregnant or breastfeeding


    General instructions

    Viropil tablet is an antiviral taken orally as prescribed dosage at a specific time regularly with food.


    Drug Interaction of Viropil Tablet 30s Pack

    Drug-Drug Interaction

    Metabolism increased by Carbamazepine, Oxcarbazepine, Phenytoin, Phenobarbital

    Metabolism decreased by Ketoconazole, Fluconazole, Itraconazole

    Serum concentration increased by Bisoprolol, Clarithromycin, Carvedilol, clomifene, acetaminophen

    Cerum concentration is decreased by Acetazolamide, carbamazepine

    St. John's wort

    Decreased absorption caused by Magnesium/aluminum-containing antacid

    side effects are increased by aceclofenac, acyclovir, amikacin

    Drug-Food Interaction

    Viropil tablet can be safely taken with food, if doubts arise kindly refer to your physician. Viropil tablet generally causes side effects thus it is advised not to be taken with alcohol.

    Drug-Disease Interaction

    • Liver disorders – used with caution in severe liver diseases. Consult physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult physician before use
    • Blood disorders – used with caution in anemia and hemophilia. Consult physician before use


    Over Dose

    Contact your doctor, pharmacist or nurse immediately.


    Missed Dose

    In general, if you take once a day dosage, the missed single dose of Viropil (Dolutegravir (50mg) + Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet can be taken within the next 12 hrs, you can take it. If it is more than 12 hrs, skip the dose and take the next dose at the recommended time. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 30?C


    Fast Tag

    Viropil tablet is used to control and treat HIV infection.

    Do not use this medication while pregnant or lactation period.

    Don’t use this medication with liver disease and kidney diseases.

    This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury, etc.