Viropil Tablet 30s Pack

Viropil Tablet contains its active substance called Dolutegravir, Lamivudine, and Tenofovir disoproxil fumarate. Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is an antiretroviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection. Dolutegravir present in Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is an integrase strand transfer inhibitor. Emtricitabine and Tenofovir Lamivudine and Tenofovir disoproxil fumarate present in Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is a nucleoside analogue. Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) works by reducing the viral load of HIV in your body. Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) improves your immune system and reduces the risk of conditions associated with HIV infection. 

Viropil Tablet contains its active substance called Dolutegravir, Lamivudine, and Tenofovir disoproxil fumarate. Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is used to treat adults and children above the weight class 35kg only who are infected by HIV-1.

Viropil Tablet contains its active substance called Dolutegravir, Lamivudine, and Tenofovir disoproxil fumarate. Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is used to help control HIV infection. Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) helps to decrease the amount of HIV in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is not a cure for HIV infection, it improves immunity that results in longevity of life. Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is recommended for use in children from 35kgs and in adults.

Viropil Tablet contains its active substance called Dolutegravir, Lamivudine, and Tenofovir disoproxil fumarate. Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is indicated in case of HIV-1 infection that causes AIDS in humans. Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) boost immunity of the affected hosts. Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is indicated in adults and children above 35kgs.

Viropil Tablet contains its active substance called Dolutegravir, Lamivudine, and Tenofovir disoproxil fumarate. Dolutegravir present in Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is a inhibits strand transfer activity of integrase in DNA thus blocks replication of HV-1. Lamivudine present in Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is an analogue that is phosphorylated to its active forms lamivudine triphosphate that incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Tenofovir disoproxil fumarate present in Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is an analogue of adenosine 5-monophosphate which is converted to tenofovir after hydrolysis after which tenofovir inhibits HIV-1 reverse transcriptase. Tenofovir competes with AMP as a substrate and competes to incorporate themselves into the DNA strand thus stops the replication of viral particles. Thus, the active HIV molecules becomes inactive and further reproduction and multiplication process is stopped.

Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) contains an integrase inhibitor and nucleoside reverse transcriptase inhibitor. Dolutegravir inhibits transfer of integrase in DNA and Lamivudine and tenofovir incorporates themselves into the DNA thus stops the replication of viral particles. Thereby preventing the formation of mature virus particles into infectious virions that spreads the infection.

• if you are allergic to Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) and its contents
• if you are pregnant
• if you are breastfeeding
• if you have kidney disease
• if you have liver disease like hepatitis B or C
• if you are diabetic
• if you have bleeding disorder like haemophilia
• if you have heart diseases

Very common side effect that occur more than 1:10 patients: headache, diarrhoea, nausea,

Common side effects that occur 1:10 patients: rash, pruritus, vomiting, abdominal pain, flatulence, insomnia, abnormal dreams, depression dizziness, tiredness, changes in LFT and increased creatine kinase, insomnia, Cough, vomiting, abdominal pain or cramps, Rash, alopecia, Arthralgia, Fatigue, malaise, fever, hypophosphataemia, asthenia

Uncommon side effects that occur 1:100 patients: hepatitis, suicidal thoughts and behaviours, joint and muscle pain, Neutropenia and anaemia, thrombocytopenia, hypokalaemia, proximal renal tubulopathy 

Rare side effects that occur 1:1000 patients: osteonecrosis, Pure red cell aplasia, Lactic acidosis, Peripheral neuropathy, Rhabdomyolysis

• Is Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) safe during pregnancy?

No, Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is not safe during pregnancy. Consult your physician.

• Can Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) be taken while breast feeding?

No, in general HIV virions can pass via breastfeeding thus it is suspected that antiretrovirals can also pass via breastfeeding.

• Can Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) be taken while alcohol consumption?

The interaction is unknown but this medication causes side effects. Thus, consult your physician.

• Can I take drive or operate heavy machineries while on Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg)?

This medication causes side effects thus caution is used while driving or operating machineries.

• Can Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) be taken as a prophylactic to exposure?

No, Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) cannot be taken as a prophylactic.

Alcohol

Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) generally causes side effects thus it is advised not to be taken with alcohol. For further queries, consult your physician.

Driving or operating machinery

It is preferred to drive or operate heavy machinery with caution as Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) causes side effects. For further queries, consult your physician.

Pregnancy

The use of Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is not recommended during pregnancy.

Breast Feeding

The use of Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effect in newborn.

Kidney Problem

Renal filtration impairment and kidney stone formation – monitor function. For further queries, consult your physician.

Liver Disease

• liver disorders and diseases like hepatitis B or C, Child Pugh disease
• Monitor liver function before and during therapy, especially in patients with other

• Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is taken with food at regular time.
• Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) should not be crushed or chewed it must be swallowed.
• After therapy has been initiated, do not take more or less of this drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing your dose without approval may cause the amount of the virus to increase making the infection more difficult to treat, or worsen side effects.

• If you are pregnant or breastfeeding inform your physician as they are not advisable.
• The recommended dosage for Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is one tablet taken once per day
• These drugs must be taken with food on a regular time basis.

• The recommended weight is above 35kgs
• The recommended dosage above this weight class is one tablet taken once per day

Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.

• New onset diabetes mellitus or hyperglycemia – Monitor blood glucose and insulin levels. When needed add oral hypoglycemic and insulin
• Blood disorders Hemophilia, hemolytic anemia
• Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
• Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
• Accumulation or Redistribution of body fat or
• immune reconstitution syndrome.
• Any sign of infection – fever or lymph node enlargement
• Lactose intolerance or galactose malabsorption

• If you have any allergy
• If you have a liver problem
• If you have a kidney problem
• If you have hypertension or any heart problem
• If you are diabetic
• If you have a blood disorder
• If you are pregnant or breastfeeding

Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is an antiretroviral taken orally as prescribed dosage at specific time regularly with food.

Drug-Drug Interaction

• Fampridine
• Carbamazepine/ Oxcarbazepine/ Clarithromycin
• Phenytoin/ Phenobarbital/ Probenecid
• Ketoconazole, Fluconazole, Itraconazole, Posaconazole, Voriconazole
• Calcium supplements, iron supplements or multivitamins
• St. John's wort
• Magnesium/ aluminium-containing antacid
• Atazanavir/ Acyclovir/ Amikacin /Amphotericin B
• Didanosine/ Deferoxime/
• Ibuprofen
• Ketorolac/ Ketoconazole
• Mefenamic acid/ Methadone
• Naproxen
• Rifampin

Drug-Food Interaction

Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) can be safely taken with food, if doubts arise kindly refer to your physician. Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) generally causes side effects thus it is advised not to be taken with alcohol. It is preferred to drive or operate heavy machinery with caution.

Drug-Disease Interaction

• Liver disorders – used with caution in severe liver diseases. Consult physician before use
• Kidney disorders – used with caution in severe kidney diseases. Consult physician before use
• Cardiac disorders – used with caution in heart failure and MI. Consult physician before use
• Respiratory disorders – used with caution in respiratory distress. Consult physician before use
• Blood disorders – used with caution in anemia and hemophilia. Consult physician before use

Contact your doctor, pharmacist or nurse immediately.

• In general, if you take once a day dosage, the missed single dose of Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) can be taken within the next 12 hrs, you can take it. If it is more than 12 hrs, skip the dose and take the next dose at the recommended time.
• Don’t take a double dose for a forgotten dose.

• Keep the medication out of children’s reach
• Keep the medication away from pets
• Once expired dispose immediately
• Store at 30C

• Viropil Tablet (Dolutegravir 50mg + Lamivudine 300mg + Tenofovir disoproxil fumarate 300mg) is a reverse transcriptase and integrase inhibitor.
• It is used to control and treat HIV infection.
• Do not use this medication while pregnant or lactation period.
• Don’t use this medication with liver disease and kidney diseases.
• This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury etc.