X-Trant 140mg Capsule

Brand Name X-Trant 140mg Capsule
Salt Composition

Estramustine (140mg)

Strength 140mg
Product Form Capsule
Pack 100 Capsule(s) in Strip
Category

Anti-Cancer

SubCategory

Prostate Cancer

Country of Origin India
Manufacturer

Natco Pharma Ltd

Manufacturer/Marketer Address Natco Pharma Ltd,Natco House, Road No:2, Banjara Hills, Hyderabad, (A.P ) 500 033 India
-20%
X-Trant 140mg Capsule, Estramustine 140mg Capsule, Price, Uses, Side effects –Drugcarts watermark

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    Medical Description of X-Trant 140mg Capsule

    X-Trant 140mg Capsule contains Estramustine 140mg used to treat prostate cancer which has spread to other parts of the body. It works by inhibiting the growth of the abnormal cells. This is not recommended in females, children, and adolescents. It is used alone or with a combination of other anti-cancer medicines.


    X-Trant 140mg Capsule Uses

    It is used in the treatment of the following conditions prostate cancer  


    X-Trant 140mg Capsule Benefits

    Prostate cancer

    It is cancer that occurs in a man’s prostate. Usually, it grows slowly and is confined to the prostate gland. Symptoms include difficulty in urinating, blood in urine, semen, bone pain, weight loss, and erectile dysfunction. This medicine helps to inhibit the multiplication of cancer cells.


    X-Trant 140mg Capsule Indication

    The X-Trant 140mg Capsule is prescribed in the following indications as Prostate cancer.


    Mechanism of action of X-Trant 140mg Capsule

    X-Trant 140mg Capsule contains Estramustine 140mg is an anti-cancer medication, hormones. It produces its action by inhibiting the function of tubulin by binding to the microtubule proteins. This antitumor effect may result from the estrogenic effect. Plasma testosterone levels get reduced while there is an increase in estrogen level which leads to apoptosis.


    How X-Trant 140mg Capsule works

    X-Trant 140mg Capsule contains Estramustine 140mg is an anti-cancer medication, hormones. It produces its action by inhibiting the production of protein which is required for the growth and reproduction of the cancer cell and it also increases the level of estrogen which results in apoptosis


    X-Trant 140mg Capsule Contraindication

    • Do not take this medicine if you are allergic to Estramustine
    • It is contraindicated to use this medicine in patients with active thrombophlebitis and thromboembolic disorder


    X-Trant 140mg Capsule Side Effects

    • Edema
    • Nausea
    • Dyspnea
    • Diarrhea
    • Breast enlargement
    • Insomnia
    • Myocardial infarction
    • Thrombophlebitis
    • Pulmonary embolism
    • Dry skin
    • Impotence
    • Leg pain
    • Decreased testosterone


    FAQs for X-Trant 140mg Capsule

    • How and in what dose should I take the X-Trant 140mg Capsule?

    Take the medicine as per the dose and duration advice by the doctor. Take the dose daily without missing the frequency of the drug.

    • Can I stop using the X-Trant 140mg Capsule immediately or do I have to slowly wean off the use?

    You should not withdraw the medicine immediately, you should taper the dose to avoid rebound effects.

    • What is X-Trant 140mg Capsule?

    It belongs to a class of anticancer medication called an antimicrotubule agent which is used to treat prostate cancer


    Precautions and general warning of X-Trant 140mg Capsule

    Alcohol

    It is not clear whether consuming alcohol may affect the effectiveness of the drug. Kindly consult with your doctor.

    Driving or operating machinery

    It is not clear that the use of this medicine will alter the ability to drive. Kindly consult with your doctor

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

    Breast Feeding

    Limited information is available regarding the use of this medicine in patients during breastfeeding. Kindly consult with your doctor.

    Kidney Problem

    It is considered safe to use this medicine in patients who are having a renal impairment. Kindly consult with your doctor.

    Liver Disease

    Therapy should be administered with caution in a patient with hepatic impairment. Kindly consult with your doctor


    How to Take X-Trant 140mg Capsule

    X-Trant 140mg Capsule can be taken orally with or without food. You should not chew, cut or crush the capsule. Take the medicine as per the dose and duration advised by your doctor. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.


    Use of X-Trant 140mg Capsule in Adult

    It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor


    Use of X-Trant 140mg Capsule in children

    Safety and efficacy were not established. Kindly consult with your doctor.


    Use of X-Trant 140mg Capsule in Elderly Patients

    X-Trant 140mg Capsule should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • The use of this medicine may increase the risk of developing thrombosis, and hypertension
    • Liver dysfunction, a metabolic bone disease associated with hypercalcemia, and renal insufficiency was reported
    • Monitor if patients are diabetic because it may decrease the glucose tolerance
    • Therapy should be administered with caution because the use of this medicine may cause fluid retention, peripheral edema, gynecomastia, and impotence
    • The use of this medicine may cause allergic reactions including angioedema
    • Kindly avoid this medicine if you are pregnant because it may cause fetal harm


    Talk to your doctor if

    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You have a receiving any concomitant medication and disease


    General instructions

    Estramustine 140mg is used to treat prostate cancer. It produces its action by inhibiting the production of protein which is required for the growth and reproduction of the cancer cell and it also increases the level of estrogen which results in apoptosis


    Drug Interaction of X-Trant 140mg Capsule

    Drug-Drug Interaction

    Deferiprone

    Use alternative drug because the combination of this medicine either increases the toxicity of the other by pharmacodynamic synergism

    Palifermin

    Use alternative drugs because the use of palifermin increases the toxicity of the estramustine by increasing the severity and duration of oral mucositis

    Calcium acetate

    Therapy should be administered with caution because the use of calcium acetate decreases the effect of estramustine by inhibiting the GI absorption

    Ofatumumab

    Therapy should be administered with caution because the combination  of this medicine either increase the effect of the other by immunosuppressive effects and also increase the risk of infection

    Drug-Food Interaction

    Food and milk products affect the level of estramustine in your body. So it is recommended to take this medicine at least one hour before or after two hours of meals.

    Drug-Disease Interaction

    Hypertension

    Therapy should  be administered with caution in patients with hypertension because the use of this medicine may increase the risk of myocardial infarction and strokes

    Thromboembolism

    Therapy should be administered with caution in patients with cerebrovascular diseases, coronary artery diseases, and a history of a thrombotic disorder because the use of estramustine and estradiol is contraindicated in patients who are with active thrombotic disorders

    Hypercalcemia in breast cancer

    When the patient is treated with estrogen. The patients who are with breast cancer and bone metastases may develop severe hypercalcemia

    Hypercalcemia

    Therapy should be administered with caution in patients with hypercalcemia because the use of this medicine may influence the metabolism of calcium and phosphorus. Intestinal absorption and calcium retention are increased which leads to hypercalcemia

    Liver diseases

    Therapy should be administered with caution in patients with liver impairment because the patients who are with impaired liver function may be at higher risk of adverse effects due to the decreased drug clearance


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 2-8°C in a refrigerator.
    • Do not freeze
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Estramustine 140mg is an anti-cancer medication, a hormone
    • It is used to treat prostate cancer in adult men
    • Kindly use birth control to avoid pregnancy while you are receiving this medicine.
    • Avoid taking milk and calcium-containing products because this may interfere with the effect of the medicine
    • Do not withdraw the medicine without consulting with a doctor
    • Monitor calcium level, liver function, blood cell count while you are receiving this medicine