Brand Name Zenotin tablet
Salt Composition

Ofloxacin (200mg) + Tinidazole (600mg)

Strength 200mg + 600mg
Product Form Tablet
Pack 10 Tablet(s) in Strip
Storage Store below 30°C
Category

Antibiotic

SubCategory

Anti-Biotic

Country of Origin India
Manufacturer

Mankind Pharma Ltd

Manufacturer/Marketer Address Mankind Pharma Ltd, Unit-III, Blocck B & C, Village Kunja, Rampur Ghat Road, Opp. Dental College, Sirmaur, Himachal Pradesh - 173025
-10%
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Availability : In Stock

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    Medical Description of Zenotin tablet

    Zenotin Tablet contains Ofloxacin 200mg and Tinidazole 500mg used to treat Diarrhoea and Dysentery. Ofloxacin 200mg is an antibiotic that helps to inhibit the growth of infection. Mainly this bacterial infection targets the urinary tract, nose, throat, skin and soft tissues, and lungs. Tinidazole 500mg  is antihelmintic which kills the parasites and anaerobic bacteria. This combination of medicine helps to kill microorganisms.


    Zenotin tablet Uses

    It is used in the treatment of the following conditions as parasitic infections such as Diarrhoea and Dysentery


    Zenotin tablet Benefits

    Parasitic infections

    It is an organism that lives in another organism like your body for its food and place to survive. You can get a parasitic infection from contaminated water, food, bug bites o sexual contact. It is a one-celled organism called protozoa which can be seen in the naked eye. Symptoms include stomach pain, nausea, vomiting, dehydration, weight loss, inflamed lymph nodes, constipation, diarrhea, rashes, eczema, hives, muscle, and joint pain.

    Diarrhea

    Infection to the digestive tract leads to increased frequency of bowel movements or loose watery bowel movements caused by bacteria called diarrhea. It leads to worsening the patient’s health condition. This medicine is used to treat this bacterial infection.

    Dysentery

    It is also called infectious diarrhea. Inflammation of the gut (intestine) leads to bloody stools or watery stools. It is most often caused by shigella bacteria (shigellosis) or an amoeba (parasite), spreading through contaminated food or water. This medicine is used to treat this bacterial infection.


    Zenotin tablet Indication

    The Zenotin Tablet is prescribed in the following indications as Diarrhoea and Dysentery


    Mechanism of action of Zenotin tablet

    Zenotin Tablet contains Ofloxacin 200mg and Tinidazole 500mg is a combination of two medicines. Ofloxacin 200mg is a quinolone antibiotic that produces its action by inhibiting the activity of a bacterial enzyme called DNA gyrase and preventing the bacterial cell from reproduction and repairing themselves and killing the bacteria which is responsible for the infection. Tinidazole 500mg is antihelmintic that produces its action by damaging their DNA and killing the parasites and anaerobic bacteria which is responsible for infections.


    How Zenotin tablet works

    Zenotin Tablet contains Ofloxacin 200mg and Tinidazole 500mg is a combination of two medicines. Ofloxacin 200mg is a quinolone antibiotic that produces its action by inhibiting the activity of a bacterial enzyme called DNA gyrase and preventing the bacterial cell from reproduction and repairing themselves and killing the bacteria which is responsible for the infection. Tinidazole 500mg is antihelmintic that produces its action by damaging their DNA and killing the parasites and anaerobic bacteria which is responsible for infections.


    Zenotin tablet Contraindication

    • Do not take this medicine if you are allergic to Tinidazole and Ofloxacin
    • The use of these medicines associated with side effects include tendinitis, tendon rupture, peripheral neuropathy, and the central nervous system effects
    • It is contraindicated to use this medicine in patients who are having a history of myasthenia gravis


    Zenotin tablet Side Effects

     

    • Anxiety
    • Abdominal pain
    • Confusion
    • Dark or clay-colored stools
    • Difficulty in urination
    • Dizziness
    • Sleepiness
    • Drowsiness 
    • Flatulence
    • Skin rash, and itching


    FAQs for Zenotin tablet

    • Is the Zenotin Tablet is effective?

    Yes, it is considered effective when you have taken the medication as per the dose and duration advised by the doctor. If you stop the medicine without completing the course of treatment it may worsen the conditions

    • Can I stop taking Zenotin Tablets when I feel better?

    No, you should not stop the medicine on your own until you complete a full course of treatment because it may worsen your conditions.

    • How long should I take the Zenotin Tablet?

    Normally the duration of this medicine depends upon the severity of the disease. You should take this according to your doctor advice


    Precautions and general warning of Zenotin tablet

    Alcohol

    The use of alcohol may produce harmful effects while you are receiving this treatment. Kindly consult with your doctor.

    Driving or operating machinery

    It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects on the fetus. Kindly consult with your doctor

    Breast Feeding

    The use of this medicine is considered unsafe during breastfeeding because it may excrete via breast milk. Kindly consult with your doctor

    Kidney Problem

    The medicine should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

    Liver Disease

    It is considered safe to use this medicine in patients with hepatic impairment and it does not require dose modification. Kindly consult with your doctor.


    How to Take Zenotin tablet

    Zenotin Tablet is taken orally with food. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.


    Use of Zenotin tablet in Adult

    It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor.


    Use of Zenotin tablet in children

    It is considered unsafe to use this medicine in children who are below 18 years old. Kindly consult with your doctor.


    Use of Zenotin tablet in Elderly Patients

    Zenotin Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

     

    • At long-term treatment seizure and aseptic meningitis were reported
    • The use of this medicine may cause encephalopathy and peripheral neuropathy
    • Kindly avoid using this medicine in absence of any suspected bacterial or parasitic infection because it increases the risk of developing drug-resistant bacteria and parasites
    • Therapy should be administered with caution in patients who are having hepatic and renal impairment, and multiple sclerosis 
    • Use this medicine with care in patients who are having a history of blood dyscrasia, agranulocytosis, leucopenia, and neutropenia
    • Kindly avoid receiving this medicine along with antiandrogen because it may cause gynecomastia
    • Long-term use may cause superinfection

    Dialysis

    • Using this medicine doesn’t show effects in patients on dialysis. This medicine should be scheduled before or after the dialysis procedure.

    Tendinitis and Tendon rupture (Muscle damage)

    • This medicine causes tendinitis and tendon rupture, which mainly affects your shoulder, hands, ankles, or other joint parts of your body. And muscle damage also occurs usually on the tendons surrounding the muscles. It may experience pain, numbness, or tingling sensations in your muscles. It should be a risk in patients of more than 60 years of age or undergone a transplant of kidney, heart, or lung. If necessary, then needs dose adjustment or replacement

                 Diarrhea

    • This medicine kills the good helpful bacteria in your stomach or intestine and causes diarrhea. It leads to worsening the patient’s health condition. Better to take probiotics with this medicine to avoid diarrhea.

                  Antibiotic resistance

    • Finish the complete course of antibiotics even if you feel better. Otherwise, it will lead to Antibiotic resistance (the bacteria may be resistant to antibiotics)


    Talk to your doctor if

    • You have a history of gastrointestinal disease, seizures, or epilepsy
    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You have a Glucose-6 phosphate dehydrogenase


    General instructions

    • Zenotin Tablet consist of Ofloxacin 200mg and Tinidazole 500mg is used in the treatment of bacterial and parasitic infection, diarrhea and dysentry.
    • Ofloxacin 200mg is a fluoroquinolone antibiotic used to treat bacterial infection by preventing the bacteria from reproduction and repairing themselves. Tinidazole 500mg is a Nitroimidazole derivative Antibacterial and Antiprotozoal drug used to treat bacterial and protozoal infections. This drug combination together prevents the infection effectively.


    Drug Interaction of Zenotin tablet

    Drug-Drug Interaction

    Dronabinol

    The use of this drug is contraindicated because the use of Tinidazole increases the toxicity of dronabinol by inhibiting aldehyde dehydrogenase

    Flibanserin

    The use of this drug is contraindicated because the use of Tinidazole will increase the effect of flibanserin by affecting its hepatic and intestinal enzyme metabolism

    Mebendazole

    Use alternative drug because the use of mebendazole increase the toxicity of Tinidazole by increasing the risk of developing toxic epidermal necrolysis

    Aluminum hydroxide

    Use alternative drugs because the use of aluminum hydroxide decreases the effect of Ofloxacin by inhibiting the GI absorption

    Escitalopram

    Therapy should be administered with caution because the use of escitalopram increase the toxicity of Ofloxacin by QTc interval

    Estradiol

    Therapy should be administered with caution because the use of Ofloxacin decreases the effect of estradiol by altering the intestinal flora and it also lowers the risk of contraceptive failure.

    Warfarin

     Use alternative drugs because the use of Tinidazole increases the effect of warfarin by decreasing its metabolism

    Drug-Food Interaction

    No interaction was found while using this medicine

    Drug-Disease Interaction

    Neurologic toxicity

    Using this medicine should be cautious in patients with neurological toxicity (convulsions and peripheral neuropathy) leads to develop numbness, tingling, or burning sensation of hands and feet like neurological effects leads to worsening the patient health condition.

    Blood Dyscrasias

    Using this medicine should be cautious in patients with blood Dyscrasias (low blood count) leads to a decrease in the blood cell count tends to developing leukopenia, thrombocytopenia, and bone marrow aplasia. It leads to worsening the patient's health condition.

    Kidney diseases

    It should be used with caution in a patient with renal impairment or kidney disease. Then it develops the risk of kidney damage. Inform your doctor and then take. Based on the patient's health condition, dose adjustment or replacement of medicine is needed.

    Liver diseases

    It should be used with caution in a patient with hepatic impairment or liver disease. Then it develops a risk of liver damage. Inform your doctor and then take. Based on the patient's health condition, dose adjustment or replacement of medicine is needed.

    Central nervous system disorders

    Using this medicine is needs caution in patients with seizures, other central nervous system abnormalities, or fits. It causes hallucinations, anxiety, confusion, and restlessness, etc. Inform the doctor, then will do dose adjustment or replacement is needed. If necessary to take this medicine with seizure medications.

    Colitis

    This medicine kills the good helpful bacteria in your stomach or intestine and causes diarrhea. This drug should be used caution in patients with gastrointestinal disease, especially colitis (swelling of the colon inner lining). It leads to worsening the patient’s health condition.

    QT prolongation

    This drug should be used with caution in patients with heart-related problems such as irregular heart rate, in which this drug alters the heart rate.


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 10-30°C room temperature.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Zenotin Tablet contains Ofloxacin 200mg and Tinidazole 500mg used to treat Diarrhoea and Dysentery. Ofloxacin 200mg is a fluoroquinolone antibiotic used to treat bacterial infection by preventing the bacteria from reproduction and repairing themselves. Tinidazole 500mg is a Nitroimidazole derivative Antibacterial and Antiprotozoal drug used to treat bacterial and protozoal infections. This drug combination together prevents the infection effectively.
    • Kindly inform your doctor if you have expericend any pain in your tendons, numbness and tingling sensations.
    • Kindly avoid this medicine if you are constipated