Zidine 300mg Tablet

Zidine tablet contains Zidovudine 300mg. Zidine (Zidovudine (300mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection. It is a nucleoside reverse transcriptase inhibitor. Zidovudine works by reducing the viral load of HIV in your body. Zidine tablet improves your immune system and reduces the risk of conditions associated with HIV infection. Zidine tablet is used in combination with other antiretrovirals for efficiency. Zidine tablet is used in children above 1 month of age or in weight more than 4 kgs and in adults.

Zidine (Zidovudine (300mg)) tablet is used to treat adults and children above 4kgs weight or more than 1 month of age who are infected by HIV-1. Zidine tablet must be taken in combination with other anti-HIV medicines. Your doctor will discuss which combination of medicines is best for you. Zidine tablet can be cautiously used in case of pregnancy because it prevents maternal fetal transmission of HIV.

Zidine (Zidovudine (300mg)) tablet is used with other anti-HIV medication to help control HIV infection. Zidine tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. It is nucleoside reverse transcriptase inhibitor. It is not a cure for HIV infection, it improves immunity that results in longevity of life. Zidine tablet is not recommended for use in children less than 4Kgs of weight or more than 1 month of age due to the increased risk of serious side effects. Zidine tablet is cautiously used in pregnancy because it prevents maternal-fetal transmission of HIV.

Zidine (Zidovudine (300mg)) tablet is indicated in the treatment of HIV-1 infection that causes AIDS in humans. Zidine tablet is used with other antiretroviral medications to boost the immunity of the affected hosts. Zidine tablet is indicated in ages above 4Kgs of body weight or more than 1 month of age. It can cautiously be used in case of pregnancy.

Zidine tablet contains Zidovudine 300mg. Zidovudine is HIV-1 nucleoside reverse transcriptase inhibitor. Zidovudine is phosphorylated to its active forms Zidovudine triphosphate that is incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.

Zidine (Zidovudine (300mg)) tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Zidine tablet inhibits the action of HIV-1 reverse transcriptase enzyme by incorporating themselves into the nucleotide sequence thus inhibits the action of the reverse transcriptase of HIV-1, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection and improves immunity.

Absolute contraindication:

• if you are allergic to Zidine (Zidovudine (300mg)) tablet
• if you are pregnant
• if you are lactating

Relative contraindication:

• if you have liver disorder like hepatitis B or C or Child Pugh disease
• if you have blood disorders like anemia/ neutropenia
• if you have renal diseases

Headache, nausea, vomiting, constipation, insomnia, loss of appetite, joint pain, and changes in the shape or location of body fat, weight loss, numbness or tingling of the hands/feet/arms/legs, lethargy, vision changes, signs of infection, signs of an overactive thyroid, difficulty breathing/swallowing/moving your eyes, drooping face, paralysis, slurred speech.

Is Zidine (Zidovudine (300mg)) tablet safe during pregnancy?

Yes, taking Zidine tablet during pregnancy has decreased the transmission of HIV from mother to fetus. Consult your physician.

Can Zidine tablet be taken while breastfeeding?

No, in general HIV virions can pass via breastfeeding thus it is suspected that antiretrovirals can also pass via breastfeeding.

Can Zidine tablet be taken while alcohol consumption?

The interaction is unknown but this medication causes side effects. Thus, consult your physician.

Can I take drive or operate heavy machineries while on Zidine tablet?

This medication causes side effects thus caution is used while driving or operating machineries.

Can Zidine tablet be taken as monotherapy in HIV treatment?

No, Zidine tablet must be taken with other antiretrovirals.

Alcohol

Zidine (Zidovudine (300mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, consult your physician.

Driving or operating machinery

It is preferred to drive or operate heavy machinery with caution as Zidine (Zidovudine (300mg)) tablet causes side effects. For further queries, consult your physician.

Pregnancy

The use of Zidine (Zidovudine (300mg)) tablet is recommended during pregnancy. The transmission of HIV particles from mother to fetus is decreased. Consult your physician.

Breast Feeding

The use of Zidine (Zidovudine (300mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effect in newborn.

Kidney Problem

renal filtration impairment – monitor function. For further queries, consult your physician.

Liver Disease

liver disorders and diseases like hepatitis B or C, hepatomegaly with steatosis

Monitor liver function before and during therapy, especially in patients with other

Zidine (Zidovudine (300mg)) tablet is taken orally with or without food.

Zidine tablet must be taken at the same time once a day as prescribed by your physician.

Zidine tablet is always taken with other antiretrovirals.

After therapy has been initiated, do not take more or less of Zidine medicine than prescribed or stop taking it without your physicians’ approval. Skipping or changing Zidine tablet dose without approval may cause the amount of the virus to increase making the infection more difficult to treat, or worsen side effects.

The recommended dosage in an adult for Zidine (Zidovudine (300mg)) tablet is 300mg taken twice per day

Zidine tablet must be taken with other antiretrovirals as prescribed by the physician without fail. These drugs must be taken with or without food on a regular time basis.

Zidine (Zidovudine (300mg)) tablet must be taken with other antiretrovirals as prescribed by the physician without fail. These drugs must be taken with or without food on a regular time basis.

Zidine (Zidovudine (300mg)) tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.

• Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
• Bone marrow supression
• Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
• New onset diabetes mellitus or hyperglycemia – Monitor blood glucose and insulin levels. When needed add oral hypoglycemic and insulin
• Accumulation or Redistribution of body fat
• immune reconstitution syndrome.
• Lactic acidosis
• Any sign of infection – fever or lymph node enlargement

If you have any allergy

If you have a liver problem

If you are pregnant or breastfeeding

Zidine (Zidovudine (300mg)) tablet is taken with other antiretrovirals orally as prescribed dosage at specific time regularly.

Drug-Drug Interaction

side effects are increased by Acyclovir, Beclomethasone, Hydroxyurea, Tretinoin

serum concentration is decreased by St. John's Wort, Cholesterol

serum concentration is increased by Caffeine, Methadone, Omeprazole

Drug-Food Interaction

Zidine (Zidovudine (300mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. Caffeine decreases the excretion of medicine thus should not be used. Zidine tablet generally causes side effects thus it is advised not to be taken with alcohol.

Drug-Disease Interaction

• Liver disorders – used with caution in severe liver diseases. Consult physician before use
• Kidney disorders – used with caution in severe kidney diseases. Consult physician before use
• Cardiac disorders – used with caution in heart failure and MI. Consult physician before use
• Respiratory disorders – used with caution in respiratory distress. Consult physician before use
• Blood disorders – used with caution in hemophilia or anemia. Consult physician before use.

Contact your doctor, pharmacist, or nurse immediately.

If you take once a day dosage, then the missed dosage if you notice within 12 hours. If it is more than 12 hours, then skip the dosage and take the next doses as usual. If you take twice a day dosage, then the missed dosage if you notice within 6 hours. If it is more than 6 hours, then skip the dosage and take the next doses as usual. Always take with other antiretrovirals Don’t take a double dose for a forgotten dose.

Keep the medication out of children’s reach

Keep the medication away from pets

Once expired dispose immediately

Store at 30?C

Zidine tablet contains Zidovudine 300mg.

Zidine (Zidovudine (300mg)) tablet is a nucleoside reverse transcriptase inhibitor.

Zidine tablet is used to control and treat HIV infection with other antiretrovirals

Do not use this medication while the lactation period.

Don’t use this medication with liver disease and blood disorders.

This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury, etc.