Zienam Monovial 250mg/250mg Injection

Brand Name Zienam Monovial 250mg/250mg Injection
Salt Composition Imipenem (250mg) + Cilastatin (250mg)
Strength 250mg + 250mg
Product Form Injection
Pack 1 Injection in 1 Vial
Storage Store at room temperature (10-30°C)
Category Antibiotic
Country of Origin India
Manufacturer MSD Pharmaceuticals Pvt Ltd
Manufacturer/Marketer AddressMSD Pharmaceuticals Pvt Ltd,Platina, 8th Floor, C.59, G Block, Bandra Kurla Complex, Bandra (East) , Mumbai - 400098,
-20%
image
M.R.P : Rs.1950.00       Price : Rs.1560.00

You Save : Rs.390.00    Inclusive of all taxes

- +
1 Injection in 1 Vial

Availability : In Stock

  Online Payment Only



    Medical Description of Zienam Monovial 250mg/250mg Injection

    Zienam Monovial 250mg/250mg Injection contains Imipenem 250mgand Cilastatin 250mg used to treat bacterial infections such as Lower respiratory tract infections, Urinary tract infections, Intraabdominal infections, Bacterial septicemia, Bone and joint infections, Skin and skin structure infections, Endocarditis, and Gynecological infections. Mainly this bacterial infection targets the bacterial infections of the respiratory tract, lungs, blood, bone and joints, skin and skin structures, heart, vagina or genital tract, and urinary tract. Imipenem 250mg is a Carbapenem antibiotic used to treat severe bacterial infections by inhibiting the bacterial cell wall synthesis which is essential for bacterial growth. Cilastatin 250mg is a Dehydropeptidase I inhibitor to inhibit the Dehydropeptidase I enzyme produced by bacteria. This enzyme destroys the action of antibiotics. The combination of this medicine helps to fight against the bacteria which are responsible for infections. This medicine is not used for common flu and cold symptoms that occur due to viral infections. This medicine is commonly prescribed for cough and colds caused by bacterial and parasitic infections


    Zienam Monovial 250mg/250mg Injection Uses

    It is used in the treatment of the following conditions as Lower respiratory tract infections, Urinary tract infections, Intraabdominal infections, Bacterial septicemia, Bone and joint infections, Skin and skin structure infections, Endocarditis, and Gynecological infections


    Zienam Monovial 250mg/250mg Injection Benefits

    Bacterial infections        

    Bacterial infection occurs when bacteria enter your body and start multiplying which may cause tissue damage and make you sick. Mostly it is caused by Staphylococcus and Streptococcus organisms. The bacterial diseases are cholera, bacterial meningitis, tetanus, gonorrhea, pneumonia, and syphilis. Symptoms include fever, chills, and sweats, inflamed lymph nodes, headache, diarrhea, abdominal pain

    Pneumonia

    It is a lung infection that causes inflammation in the alveoli. It is usually caused by Streptococcus pneumonia. Symptoms include chest pain, fatigue, fever, sweating, nausea, vomiting, diarrhea, breathing difficulty, cough, and confusion

    Skin infection

    It is usually caused by bacteria, fungi, viruses, and parasites. Common skin infection includes cellulitis, impetigo. Symptoms include red skin, blisters, swelling, pain, red spots, and tenderness

    Bacterial meningitis

    Infection and inflammation to the meninges (in the brain). It is caused by Streptococcus pneumonia, Neisseria meningitis, Haemophilus influenza. Symptoms include high fever, stiff neck, severe headache, confusion, and sensitivity to light.

    Intra-abdominal infections

    It is an accumulation of fluid surrounded by inflamed tissue which is present inside your bellies such as peritonitis, pancreatitis, diverticulitis, cholecystitis, and cholangitis. It is caused by Enterobacteriaceae, Enterococci, and Bacteroides fragilis. Symptoms include lack of appetite, belly pain, fever, change in bowel movements, and rectal tenderness.

    Urinary tract infection

    It is a type of infection that affects the urethra, kidneys, and bladder. It is caused by Escherichia coli (E.coli). Symptoms include abdominal pain, frequent urination, dysuria, blood in urine, foul-smell while urinating

    Bacterial septicemia

    The presence of bacteria in your bloodstream. It is caused by Staphylococcus aureus, E.coli, Pneumococcal bacteria, Salmonella, and Pseudomonas aeruginosa. Symptoms include fever, chills, and shivering.

    Bacterial endocarditis

    Infection in the inner lining of the heart. It usually occurs when the bacteria enter your bloodstream by destroying your immune system. Symptoms include muscle pain, fatigue, fever, chills, night sweats, shortness of breath, heart murmur, and swelling.

    Bone and joint infections

    Bone infection is also called Osteomyelitis. It is caused by bacteria called staphylococcus which travels through the bloodstream to the weak area in a bone. Symptoms include fever, pain, fatigue, tenderness, redness, and warmth.


    Zienam Monovial 250mg/250mg Injection Indication

    Zienam Monovial 250mg/250mg Injection is prescribed in the following indications as  Lower respiratory tract infections, Urinary tract infections, Intraabdominal infections, Bacterial septicemia, Bone and joint infections, Skin and skin structure infections, Endocarditis, and Gynecological infections


    Mechanism of action of Zienam Monovial 250mg/250mg Injection

    Zienam Monovial 250mg/250mg Injection contains Imipenem 250mg and Cilastatin 250mg is a combination of two medicines. Imipenem 250mg is a Carbapenem antibiotic is used to treat bacterial infections. It blocks the bacterial cell wall synthesis which is essential for bacterial growth and also prevents the spreading of infections without making them resistant to further treatment. Cilastatin 250mg is a Dehydropeptidase I inhibitor to inhibit the Dehydropeptidase I enzyme produced by bacteria. This enzyme destroys the action of Imipenem antibiotics. Then Imipenem remains in our body for longer time effectiveness.


    How Zienam Monovial 250mg/250mg Injection works

    Zienam Monovial 250mg/250mg Injection contains Imipenem 250mg and Cilastatin 250mg is a combination of two medicines. Imipenem 250mg is a Carbapenem antibiotic is used to treat bacterial infections. It blocks the bacterial cell wall synthesis which is essential for bacterial growth and also prevents the spreading of infections without making them resistant to further treatment. Cilastatin 250mg is a Dehydropeptidase I inhibitor to inhibit the Dehydropeptidase I enzyme produced by bacteria. This enzyme destroys the action of Imipenem antibiotics. Then Imipenem remains in our body for longer time effectiveness.


    Zienam Monovial 250mg/250mg Injection Contraindication

    • Do not take this medicine if you are allergic to Imipenem and Cilastatin
    • Kindly avoid this medicine if you are having hepatic and renal impairment
    • Seizures are most commonly found in patients who are with CNS disorders


    Zienam Monovial 250mg/250mg Injection Side Effects

    • Phlebitis
    • Eosinophilia
    • Seizures
    • Abnormal urinalysis
    • Agitation
    • Anaphylaxis
    • Anemia
    • Dizziness
    • Dyskinesia
    • Elevated liver function test
    • Increased prothrombin time
    • Neutropenia
    • Palpitations
    • Pruritus
    • Pseudomembranous colitis


    FAQs for Zienam Monovial 250mg/250mg Injection

    • How long should I take the Zienam Monovial 250mg/250mg Injection?

    Normally the duration of this medicine depends upon the severity of the disease. You should take this according to your doctor advice

    • Is the Zienam Monovial 250mg/250mg Injection is effective?

    Yes, it is considered effective when you have taken the medication as per the dose and duration advised by the doctor. If you stop the medicine without completing the course of treatment it may worsen the conditions

    • What if I do not get better after using the Zienam Monovial 250mg/250mg Injection?

    If you do not feel better after completing the full course of treatment kindly inform your doctor.


    Precautions and general warning of Zienam Monovial 250mg/250mg Injection

    Alcohol

    It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

    Driving or operating machinery

    It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects on the fetus. Kindly consult with your doctor

    Breast Feeding

    The use of this medicine is considered safe during breastfeeding because it does not excrete via breastmilk. Kindly consult with your doctor

    Kidney Problem

    The Injection should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor

    Liver Disease

    Limited information is available regarding the use of this medicine to patients who are having hepatic impairment. Kindly consult with your doctor


    How to Take Zienam Monovial 250mg/250mg Injection

    Zienam Monovial 250mg/250mg Injection comes in an intravenous dosage form and shakes well before use. It is injected by a health care professional in doctor clinics, hospitals. Use the injection as prescribed by your doctor. Do not discontinue the medicine when you feel better kindly consult together with your doctor.


    Use of Zienam Monovial 250mg/250mg Injection in Adult

    It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.


    Use of Zienam Monovial 250mg/250mg Injection in children

    Zienam Monovial 250mg/250mg Injection should be administered with caution in children who are having central nervous system problems. Kindly consult with your doctor.


    Use of Zienam Monovial 250mg/250mg Injection in Elderly Patients

    Zienam Monovial 250mg/250mg Injection should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • Therapy should be administered with caution if you have a history of penicillin allergy and gastrointestinal disease
    • Long-term use may cause bacterial or fungal overgrowth
    • The use of this medicine in renal failure patients may cause thrombocytopenia
    • The use of this medicine can cause Clostridium difficile-associated diarrhea
    • It produces limited effect against anaerobes
    • The use of this medicine may decrease the serum level of divalproex sodium


    Talk to your doctor if

    • You have a history of gastrointestinal disease
    • You have diarrhea during the treatment
    • You have any sudden allergic effects like rashes, itching, inflammation, dizziness, and difficulty in breathing
    • You are not responding to the treatment


    General instructions

    Zienam Monovial 250mg/250mg Injection contains Imipenem 250mg and Cilastatin 250mg used to treat bacterial infections such as Lower respiratory tract infections, Urinary tract infections, Intraabdominal infections, Bacterial septicemia, Bone and joint infections, Skin and skin structure infections, Endocarditis, and Gynecological infections. Mainly this bacterial infection targets the bacterial infections of the respiratory tract, lungs, blood, bone and joints, skin and skin structures, heart, vagina or genital tract, and urinary tract. Imipenem 250mg is a Carbapenem antibiotic used to treat severe bacterial infections by inhibiting the bacterial cell wall synthesis which is essential for bacterial growth. Cilastatin 500mg is a Dehydropeptidase I inhibitor to inhibit the Dehydropeptidase I enzyme produced by bacteria. This enzyme destroys the action of antibiotics. The combination of this medicine helps to fight against the bacteria which are responsible for infections.


    Drug Interaction of Zienam Monovial 250mg/250mg Injection

    Drug-Drug Interaction

    BCG vaccine live

    The use of this medicine is contraindicated because the use of medicine decreases the effect of the BCG vaccine live by pharmacodynamic antagonism

    Cholera vaccine

    Use alternative medicine, because the use of the cholera vaccine with antibiotics may activate the vaccine strain. So, avoid receiving this combination of medicines before 14 days of vaccination

    Probenecid

    It is a uricosuric used to treat chronic gout and gouty arthritis. This medicine alters the action of probenecid. . Kindly consult with your doctor

    Valproic acid

    Use alternative drugs because the combination of this medicine may decrease the effect of valproic acid by an unknown mechanism.

    Cyclosporine

    Therapy should be administered with caution because the use of imipenem decrease or increase the cyclosporine serum concentration level

    Drug-Food Interaction

    The food may increase the effect of  the medicine in your body so it is advised to take this Injection with food to increase the absorption

    Drug-Disease Interaction

    Central nervous system disorders

    It should be used with caution in patients with seizures, other central nervous system abnormalities, or fits. It causes hallucinations, anxiety, confusion, and restlessness. Kindly inform your doctor if you have experienced any of these effects

     Colitis

    This medicine kills the good helpful bacteria in your stomach or intestine and causes diarrhea. This drug should be used caution in patients with gastrointestinal disease, especially colitis (swelling of the colon inner lining). It leads to worsening the patient's health conditions.

    Kidney disease

    It should be used with caution in a patient with renal impairment or kidney disease. Then it leads to the risk of kidney damage. Inform your doctor, and then take for a better life. Based on your conditions, dose adjustment is needed.


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 10-30°C room temperature.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    Zienam Monovial 250mg/250mg Injection contains Imipenem 250mg and Cilastatin 250mg used to treat bacterial infections such as Lower respiratory tract infections, Urinary tract infections, Intraabdominal infections, Bacterial septicemia, Bone and joint infections, Skin and skin structure infections, Endocarditis, and Gynecological infections. Mainly this bacterial infection targets the bacterial infections of the respiratory tract, lungs, blood, bone and joints, skin and skin structures, heart, vagina or genital tract, and urinary tract.

    Imipenem 250mg is a Carbapenem antibiotic used to treat bacterial infections. It blocks the bacterial cell wall synthesis which is essential for bacterial growth. Cilastatin 500mg is a Dehydropeptidase I inhibitor to inhibit the Dehydropeptidase I enzyme produced by bacteria. This enzyme destroys the action of antibiotics. This drug combination together prevents the infection effectively.

    This medicine is not used for common flu and cold symptoms. And not treat viral infections. This medicine is commonly prescribed for cough and colds caused by bacterial and parasitic infections.

    This medicine is contraindicated to allergic symptoms such as skin rash, itching, swelling, and breathing difficulties.