Zilion 300mg Tablet

Brand Name Zilion 300mg Tablet
Salt Composition

Zidovudine (300mg)

Strength 300mg
Product Form Tablet
Pack 10 Tablet(s) in Strip
Storage Store below 30°C
Category

HIV

SubCategory

HIV

Country of Origin India
Manufacturer

Cadila Pharmaceuticals

Manufacturer/Marketer Address Cadila Pharmaceuticals,,Cadila Corporate Campus, Sarkhej Dholka road, Bhat, India
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M.R.P : Rs.215.00       Price : Rs.165.55

You Save : Rs.49.45    Inclusive of all taxes

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10 Tablet(s) in Strip

Availability : In Stock


    Medical Description of Zilion 300mg Tablet

    Zilion tablet contains Zidovudine 300mg. Zilion (Zidovudine (300mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection. It is a nucleoside reverse transcriptase inhibitor. Zidovudine works by reducing the viral load of HIV in your body. Zilion tablet improves your immune system and reduces the risk of conditions associated with HIV infection. Zilion tablet is used in combination with other antivirals for efficiency. Zilion tablet is used in children above 1 month of age or in weight more than 4 kgs and in adults.


    Zilion 300mg Tablet Uses

    Zilion (Zidovudine (300mg)) tablet is used to treat adults and children above 4kgs weight or more than 1 month of age who are infected by HIV-1. Zilion tablet must be taken in combination with other anti-HIV medicines. Your doctor will discuss which combination of medicines is best for you. Zilion tablet can be cautiously used in case of pregnancy because it prevents maternal fetal transmission of HIV.


    Zilion 300mg Tablet Benefits

    Zilion (Zidovudine (300mg)) tablet is used with other anti-HIV medication to help control HIV infection. Zilion tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. It is nucleoside reverse transcriptase inhibitor. It is not a cure for HIV infection, it improves immunity that results in longevity of life. Zilion tablet is not recommended for use in children less than 4Kgs of weight or more than 1 month of age due to the increased risk of serious side effects. Zilion tablet is cautiously used in pregnancy because it prevents maternal-fetal transmission of HIV.


    Zilion 300mg Tablet Indication

    Zilion (Zidovudine (300mg)) tablet is indicated in the treatment of HIV-1 infection that causes AIDS in humans. Zilion tablet is used with other antiviral medications to boost the immunity of the affected hosts. Zilion tablet is indicated in ages above 4Kgs of body weight or more than 1 month of age. It can cautiously be used in case of pregnancy.


    Mechanism of action of Zilion 300mg Tablet

    Zilion tablet contains Zidovudine 300mg. Zidovudine is HIV-1 nucleoside reverse transcriptase inhibitor. Zidovudine is phosphorylated to its active forms Zidovudine triphosphate that is incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.


    How Zilion 300mg Tablet works

    Zilion (Zidovudine (300mg)) tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Zilion tablet inhibits the action of HIV-1 reverse transcriptase enzyme by incorporating themselves into the nucleotide sequence thus inhibits the action of the reverse transcriptase of HIV-1, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection and improves immunity.


    Zilion 300mg Tablet Contraindication

    Absolute contraindication:

    • if you are allergic to Zilion (Zidovudine (300mg)) tablet
    • if you are pregnant
    • if you are lactating

    Relative contraindication:

    • if you have liver disorder like hepatitis B or C or Child Pugh disease
    • if you have blood disorders like anemia/ neutropenia
    • if you have renal diseases


    Zilion 300mg Tablet Side Effects

    Headache, nausea, vomiting, constipation, insomnia, loss of appetite, joint pain, and changes in the shape or location of body fat, weight loss, numbness or tingling of the hands/feet/arms/legs, lethargy, vision changes, signs of infection, signs of an overactive thyroid, difficulty breathing/swallowing/moving your eyes, drooping face, paralysis, slurred speech.


    FAQs for Zilion 300mg Tablet

    Is Zilion (Zidovudine (300mg)) tablet safe during pregnancy?

    Yes, taking Zilion tablet during pregnancy has decreased the transmission of HIV from mother to fetus. Consult your physician.

    Can Zilion tablet be taken while breastfeeding?

    No, in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding.

    Can Zilion tablet be taken while alcohol consumption?

    The interaction is unknown but this medication causes side effects. Thus, consult your physician.

    Can I take drive or operate heavy machineries while on Zilion tablet?

    This medication causes side effects thus caution is used while driving or operating machineries.

    Can Zilion tablet be taken as monotherapy in HIV treatment?

    No, Zilion tablet must be taken with other antivirals.


    Precautions and general warning of Zilion 300mg Tablet

    Alcohol

    Zilion (Zidovudine (300mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution as Zilion (Zidovudine (300mg)) tablet causes side effects. For further queries, consult your physician.

    Pregnancy

    The use of Zilion (Zidovudine (300mg)) tablet is recommended during pregnancy. The transmission of HIV particles from mother to fetus is decreased. Consult your physician.

    Breast Feeding

    The use of Zilion (Zidovudine (300mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effect in newborn.

    Kidney Problem

    renal filtration impairment – monitor function. For further queries, consult your physician.

    Liver Disease

    liver disorders and diseases like hepatitis B or C, hepatomegaly with steatosis

    Monitor liver function before and during therapy, especially in patients with other


    How to Take Zilion 300mg Tablet

    Zilion (Zidovudine (300mg)) tablet is taken orally with or without food.

    Zilion tablet must be taken at the same time once a day as prescribed by your physician.

    Zilion tablet is always taken with other antivirals.

    After therapy has been initiated, do not take more or less of Zilion medicine than prescribed or stop taking it without your physicians’ approval. Skipping or changing Zilion tablet dose without approval may cause the amount of the virus to increase making the infection more difficult to treat, or worsen side effects.


    Use of Zilion 300mg Tablet in Adult

    The recommended dosage in an adult for Zilion (Zidovudine (300mg)) tablet is 300mg taken twice per day

    Zilion tablet must be taken with other antivirals as prescribed by the physician without fail. These drugs must be taken with or without food on a regular time basis.


    Use of Zilion 300mg Tablet in children

    Zilion (Zidovudine (300mg)) tablet must be taken with other antivirals as prescribed by the physician without fail. These drugs must be taken with or without food on a regular time basis.


    Use of Zilion 300mg Tablet in Elderly Patients

    Zilion (Zidovudine (300mg)) tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Bone marrow supression
    • Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
    • New onset diabetes mellitus or hyperglycemia – Monitor blood glucose and insulin levels. When needed add oral hypoglycemic and insulin
    • Accumulation or Redistribution of body fat
    • immune reconstitution syndrome.
    • Lactic acidosis
    • Any sign of infection – fever or lymph node enlargement


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you are pregnant or breastfeeding


    General instructions

    Zilion (Zidovudine (300mg)) tablet is taken with other antivirals orally as prescribed dosage at specific time regularly.


    Drug Interaction of Zilion 300mg Tablet

    Drug-Drug Interaction

    side effects are increased by Acyclovir, Beclomethasone, Hydroxyurea, Tretinoin

    serum concentration is decreased by St. John's Wort, Cholesterol

    serum concentration is increased by Caffeine, Methadone, Omeprazole

    Drug-Food Interaction

    Zilion (Zidovudine (300mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. Caffeine decreases the excretion of medicine thus should not be used. Zilion tablet generally causes side effects thus it is advised not to be taken with alcohol.

    Drug-Disease Interaction

    • Liver disorders – used with caution in severe liver diseases. Consult physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult physician before use
    • Blood disorders – used with caution in hemophilia or anemia. Consult physician before use.


    Over Dose

    Contact your doctor, pharmacist or nurse immediately.


    Missed Dose

    If you take once a day dosage, then the missed dosage if you notice within 12 hours. If it is more than 12 hours, then skip the dosage and take the next doses as usual. If you take twice a day dosage, then the missed dosage if you notice within 6 hours. If it is more than 6 hours, then skip the dosage and take the next doses as usual. Always take with other antivirals Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 30°C


    Fast Tag

    Zilion tablet contains Zidovudine 300mg.

    Zilion (Zidovudine (300mg)) tablet is a nucleoside reverse transcriptase inhibitor.

    Zilion tablet is used to control and treat HIV infection with other antivirals

    Do not use this medication while the lactation period.

    Don’t use this medication with liver disease and blood disorders.

    This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury, etc.