Zumustin 100mg Injection

Brand Name Zumustin 100mg Injection
Salt Composition

Bendamustine (100mg)

Strength 100mg
Product Form Injection
Pack 1 Injection in 1 Vial
Storage Store below 30°C
Category

Anti-Cancer

SubCategory

Blood Cancer

Country of Origin India
Manufacturer

Zuventus Healthcare Ltd

Manufacturer/Marketer Address Zuventus Healthcare Ltd, Office No. 5119, 5th Floor, 'D' Wing, Oberoi Garden Estates, Chandivili, Andheri (E), Mumbai - 400 072.
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Zumustin 100mg Injection, Bendamustine 100mg Injection, Price, Uses, Side effects – Drugcarts watermark
M.R.P : Rs.2028.00       Price : Rs.1622.40

You Save : Rs.405.60    Inclusive of all taxes

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1 Injection in 1 Vial

Availability : In Stock


    Medical Description of Zumustin 100mg Injection

    Zumustin 100mg Injection contains Bendamustine 100mg used to treat Chronic lymphocytic leukemia, Non-Hodgkin lymphoma that has progressed within six months of treatment with rituximab. It is used alone or in combination with other medications as chemotherapy. It works by inhibiting the growth and multiplication of cancer cells by damaging the DNA and RNA of cancer cells. It is not recommended in children and adolescents who are below 18 years old.


    Zumustin 100mg Injection Uses

    It is used in the treatment of the following conditions as Chronic lymphocytic leukemia, and Non-Hodgkin lymphoma.

     


    Zumustin 100mg Injection Benefits

    Chronic lymphatic leukemia

    It is a type of blood and bone marrow cancer. The exact cause is unknown but it is assumed that some changes happen in the DNA of blood-producing cells. It progresses more slowly when compared with other leukemia. Symptoms include inflamed lymph nodes, fever, night sweats, weight loss, enlarged spleen, fatigue, and frequent infections.

    Non-Hodgkins leukemia

    It is also known as Non-Hodgkin’s disease, cancer in part of your immune system called the lymphatic system. It occurs when there is a change in the DNA of white blood cells called B lymphocytes. Symptoms include fever, night sweats, weight loss, severe itching, increased sensitivity, and swelling of lymph nodes.


    Zumustin 100mg Injection Indication

    The Zumustin 100mg Injection is prescribed in the following indications as

    • Non-Hodgkin lymphoma
    • Chronic lymphocytic leukemia
    • It is used as an orphan drug in the treatment of mantle cell lymphoma, Waldenström's Macroglobulinemia, Recurrent multiple myeloma


    Mechanism of action of Zumustin 100mg Injection

    Zumustin 100mg Injection contains Bendamustine 100mg is an anti-cancer medication, an alkylating agent produces its action by causing intra- and inter-strand crosslinks between DNA bases causing a break in DNA strand thus apoptosis is induced resulting in cell death of abnormal DNA containing cancer cells.


    How Zumustin 100mg Injection works

    Zumustin 100mg Injection contains Bendamustine 100mg is an anti-cancer medication, an alkylating agent produces its action by causing fragmentation in the DNA base pair which leads to inhibition of further synthesis and transcription of DNA. Thus it inhibits proliferation and induces apoptosis (cell death) of these abnormal cancer cells.


    Zumustin 100mg Injection Contraindication

    • Do not take this medicine if you are allergic to Bendamustine
    • It is contraindicated to use this medicine in patients who are having atrial fibrillation, congestive heart failure, myocardial infarction, and palpitation


    Zumustin 100mg Injection Side Effects

    • Lymphopenia
    • Anemia
    • Vomiting
    • Diarrhea
    • Constipation
    • Increases bilirubin
    • Cough
    • Weight loss
    • Dehydration
    • Peripheral edema
    • Abdominal pain
    • Urinary tract infection
    • Taste alteration
    • Chest pain
    • Hypokalemia
    • Injection site pain
    • Febrile neutropenia


    FAQs for Zumustin 100mg Injection

    • Is Zumustin 100mg Injection safe?

    Yes, the use of this medicine is considered safe if you have taken the medicine as per the dose and duration advised by the doctor.

    • I am experiencing nausea and fatigue. Is this due to Zumustin 100mg injection?

    Yes, the common side effect of this medicine is nausea and fatigue so it is better to eat more frequent meals to decrease nausea and also avoid foods that are salty, spicy, fatty. Drink plenty of rest and do light exercise to keep yourself active

    • Does Zumustin 100mg Injection cause hair loss?

    Yes, one of the common side effects of this medicine is hair loss. This will get treated once you stop the treatment.


    Precautions and general warning of Zumustin 100mg Injection

    Alcohol

    It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

    Driving or operating machinery

    It is not clear that the use of this medicine will affect the ability to drive. Kindly consult with your doctor.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

    Breast Feeding

    The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

    Kidney Problem

    It is considered safe to use this medicine in patients who are having a renal impairment. Kindly consult with your doctor.

    Liver Disease

    Therapy should be administered with caution in patients who are having hepatic impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.


    How to Take Zumustin 100mg Injection

    Zumustin 100mg Injection comes in a liquid solution as an intravenous. It is injected by a health care professional in doctor clinics, hospitals. Use the injection as prescribed by your doctor. Do not discontinue the medicine when you feel better kindly consult together with your doctor.


    Use of Zumustin 100mg Injection in Adult

    It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.


    Use of Zumustin 100mg Injection in children

    Safety and efficacy were not established in children. Kindly consult with your doctor.


    Use of Zumustin 100mg Injection in Elderly Patients

    Zumustin 100mg Injection should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • The use of this medicine may get interrupted if a severe infusion reaction occurs
    • Therapy should be administered with caution in patients who are with mild-moderate renal and hepatic impairment
    • Myelosuppression may occur
    • Tumor lysis syndrome was reported while you are receiving this medicine
    • The use of this medicine can cause fetal harm, so it is advised to females to use effective contraception to avoid pregnancy
    • The use of this medicine may increase the risk for developing reactivation of infection includes hepatitis Bm cytomegalovirus, mycobacterium tuberculosis, and herpes zoster
    • Progressive multifocal leukoencephalopathy was reported


    Talk to your doctor if

    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You have a receiving any concomitant medication and disease
    • You develop shortness of breath


    General instructions

    Bendamustine 100mg is used to treat Chronic lymphocytic leukemia, Non-Hodgkin lymphoma. It produces its action by causing fragmentation in the DNA base pair which leads to inhibition of further synthesis and transcription of DNA. Thus it inhibits proliferation and induces apoptosis (cell death) of these abnormal cancer cells.


    Drug Interaction of Zumustin 100mg Injection

    Drug-Drug Interaction

    Tofacitinib

    Use alternative drug because the combination of this medicine either increase the toxicity of the other by immunosuppressive effect and it also increases the risk for developing an infection.

    Carbamazepine

    Therapy should be administered with caution because the use of carbamazepine decreases the effect of bendamustine by affecting its hepatic enzyme metabolism.

    Cisplatin

    Therapy should be administered with caution because the combination of this medicine either increases the toxicity of the other by pharmacodynamic synergism

    Ethinyl estradiol

    Therapy should be administered with caution because the use of Ethinyl estradiol increases the effect of bendamustine by decreasing its metabolism

    Secobarbital

    Therapy should be administered with caution because the use of secobarbital increases the effect of bendamustine by increasing its metabolism

    Drug-Food Interaction

    The use of caffeine may increase the blood level of bendamustine and it also increases the risk for developing side effect that affects your bone marrow. Kindly consult with your doctor if you have experience paleness, fatigue, dizziness, fainting, bleeding, fever, chills, sore throat, body aches, and fever.

    Drug-Disease Interaction

    Infections

    The use of this medicine is contraindicated in patients who are having the infectious disease because of their cytotoxic effect their induce myelosuppression.

    Tumor lysis syndrome

    After taking the first infusion of this medicine in patients who are with Non-Hodgkin lymphoma may cause acute renal failure, hyperkalemia, hypocalcemia, hyperuricemia, and hyperphosphatemia

    Hepatic impairment

    Therapy should be administered with caution in patients with hepatic impairment and it should not be used in patients with moderate to severe hepatic impairment

    Renal impairment

    Therapy should be used in patients whose creatinine clearance value is less than 40ml/min

    Myelosuppression

    Therapy should not be administered in patients whose neutrophil count is less than 1,100/mm3. The use of this medicine may cause myelosuppression, bone marrow failure, and severe immunosuppression which leads to developing septic shock and sepsis


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 25°C at room temperature.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Bendamustine 100mg is an anti-cancer medication, an alkylating agent
    • It is used to treat Chronic lymphocytic leukemia, Non-Hodgkin lymphoma
    • Do not withdraw the medicine without consulting with a doctor
    • Kindly consult with your doctor if you have experienced shortness of breath, chest pain, loss of appetite, and dark urine while you are receiving this medicine


    References