Zybirra 500mg Tablet
Brand Name | Zybirra 500mg Tablet |
Salt Composition |
Abiraterone Acetate (500mg) |
Strength | 500mg |
Product Form | Tablet |
Storage | Store below 30°C |
Category |
Anti-Cancer |
SubCategory |
Prostate Cancer |
Country of Origin | India |
Manufacturer |
Zydus Cadila |
Manufacturer/Marketer Address | Zydus Cadila,Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India. |
You Save : Rs.12,142.86 Inclusive of all taxes
- Castration-resistant
- Chemotherapy with docextal has failed
- Metastasis to other organs
- Do not take this medicine if you are allergic to Abiraterone
- It is not recommended to use in women and children
- Increased liver enzymes
- Hypertriglyceridemia
- Fatigue
- Hypokalemia
- Edema
- Constipation
- Insomnia
- Confusion
- Diarrhea
- Hot flush
- Urinary tract infection
- Hypertension
- Muscle discomfort
- Why do I need to take prednisone with the Zybirra 500mg Tablet?
- How to take an Zybirra 500mg Tablet?
- I am experiencing nausea and fatigue. Is this due to the Zybirra 500mg Tablet?
- Therapy should be administered with caution in patients with a history of cardiovascular disease
- Hypertension, hypokalemia, and fluid retention may occur due to increased mineralocorticoid due to CYP17 inhibition
- Kindly monitor for QT prolongation in patients who develop hypokalemia
- While taking the medicine along with prednisone you may have adrenocortical insufficiency
- Kindly avoid pregnancy while you are receiving this medicine because it will cause fetal harm and loss of pregnancy
- You are not responding to the treatment
- You have experienced any allergic reaction like rashes and itching
- You have a receiving any concomitant medication and disease
- Stored at 10-30°C room temperature.
- Protect from light and heat.
- Keep away from children and pets. Otherwise, it becomes toxic to them.
- Disposed of properly in a suitable bag.
- Abiraterone Acetate 500mg is an anti-cancer medication, an antiandrogen
- It is used to treat prostate cancer in adult men
- Take this medicine on an empty stomach
- Kindly use birth control to avoid pregnancy while you are receiving this medicine.
- Monitor blood pressure, liver function, and potassium level in your blood while you are receiving this medicine
- Abiraterone Acetate. Patheon Inc.: Mississauga, Canada; 2011 [revised May 2016]. [Accessed 26 Mar. 2019] (online) Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/202379s023lbl.pdf
- Abiraterone: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 19 August 2017]. Available from: https://medlineplus.gov/druginfo/meds/a611046.html
- Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 19 August 2017]. Available from: https://www.tga.gov.au/prescribing-medicines-pregnancy-database
Medical Description of Zybirra 500mg Tablet
Zybirra 500mg Tablet contains Abiraterone Acetate 500mg used to treat prostate cancer in adult men along with prednisone that has spread to other parts of your body. It works by inhibiting the enzyme which is responsible for the production of male hormone (androgen) and stops the growth of cancer cells. It is used with other medicines like chemotherapy.
Zybirra 500mg Tablet Uses
It is used in the treatment of the following conditions as Prostate cancer
Zybirra 500mg Tablet Benefits
Prostate cancer
It is cancer that occurs in a man’s prostate. Usually, it grows slowly and is confined to the prostate gland. Symptoms include difficulty in urinating, blood in urine, semen, bone pain, weight loss, and erectile dysfunction. This medicine helps to inhibit the multiplication of cancer cells.
Metastatic castration-Resistant prostate cancer
It is an advanced form of advanced prostate cancer. It is also found in other parts of the body and it can also spread lymph nodes, bones, the bladder rectum, liver, lungs, and brain. Symptoms include difficulty in urination, pain while urinating, weight loss, shortness of breath, and bone pain. This medicine helps to inhibit the multiplication of cancer cells.
Zybirra 500mg Tablet Indication
The Zybirra 500mg Tablet is prescribed in the following indications as prostate cancer. It is recommended when prostate cancer is
Mechanism of action of Zybirra 500mg Tablet
Zybirra 500mg Tablet contains Abiraterone Acetate 500mg is an anti-cancer medication, an antiandrogen. It produces its action by inhibiting 17-alpha-hydroxylase also called CYP17 present in the testis, adrenal glands, and prostate. In general, CYP 17, assists in the conversion process of progesterone and androstenedione. Abiraterone acetate reduces serum testosterone and progesterone levels. The visible decline in (Prostate-specific antigen) PSA levels is seen with the use of this medicine in the treatment of chemo-resistant metastatic prostate cancer.
How Zybirra 500mg Tablet works
Zybirra 500mg Tablet contains Abiraterone Acetate 500mg is an anti-cancer medication, an antiandrogen. It produces its action by inhibiting 17-alpha-hydroxylase used in conversion processes that results in the formation of progesterone and androstenedione. It reduces serum levels of progesterone and testosterone levels by decreasing the size of prostate cancer. It treats prostate cancer by inhibiting testosterone formation and decreasing serum testosterone levels.
Zybirra 500mg Tablet Contraindication
Zybirra 500mg Tablet Side Effects
FAQs for Zybirra 500mg Tablet
Yes, you have to take prednisone along with this medicine because the combination of this medicine reduces the risk of getting high blood pressure, fluid retention, decreased potassium in your blood.
Kindly take this medicine on an empty stomach with water. 1 hour before or after 2 hours after eating because the food may increase the level of Zybirra in blood.
Yes, the common side effect of this medicine is nausea and fatigue so it is better to eat more frequent meals to decrease nausea and also avoid foods that are salty, spicy, fatty. Drink plenty of rest and do light exercise to keep yourself active
Precautions and general warning of Zybirra 500mg Tablet
Alcohol
It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.
Driving or operating machinery
It is considered safe to drive while you are receiving this medicine it does not affect your ability to drive. Kindly consult with your doctor.
Pregnancy
The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor
Breast Feeding
The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor
Kidney Problem
It is considered safe to use this medicine in patients who are having a renal impairment. Kindly consult with your doctor.
Liver Disease
Therapy should be administered with caution in patients who are having hepatic impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.
How to Take Zybirra 500mg Tablet
Zybirra 500mg Tablet is to be taken on an empty stomach. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.
Use of Zybirra 500mg Tablet in Adult
It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor
Use of Zybirra 500mg Tablet in children
Safety and efficacy were not established. Kindly consult with your doctor.
Use of Zybirra 500mg Tablet in Elderly Patients
Zybirra 500mg Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.
Other general warnings
Talk to your doctor if
General instructions
Abiraterone Acetate 500mg is used to treat prostate cancer. It produces its action by inhibiting 17-alpha-hydroxylase used in conversion processes that results in the formation of progesterone and androstenedione. It reduces serum levels of progesterone and testosterone levels by decreasing the size of prostate cancer. It treats prostate cancer by inhibiting testosterone formation and decreasing serum testosterone levels.
Drug Interaction of Zybirra 500mg Tablet
Drug-Drug Interaction
Ritonavir
It is contraindicated to use this medicine because the use of abiraterone will increase the effect of ritonavir by decreasing its metabolism
Apalutamide
Use alternative drugs because the use of apalutamide will decrease the effect of abiraterone by affecting its hepatic and intestinal enzyme metabolism.
Dichlorphenamide
Therapy should be administered with caution because the combination of this medicine decreases the serum potassium level.
Ceritinib
Therapy should be administered with caution because the use of abiraterone increases the effect of ceritinib by P-glycoprotein efflux transporter.
Drug-Food Interaction
Food may increase the amount of medicine get absorbed by your body and it also increases the side effects such as high blood pressure, water retention, low blood potassium level.
Drug-Disease Interaction
Hepatic impairment
Therapy should be administered with caution in patients with severe hepatic toxicity includes fulminant hepatitis, acute hepatic failure, and death.
Cardiovascular diseases
Therapy should be administered with caution in patients with increased blood pressure, hypokalemia, recent myocardial infarction, and ventricular arrhythmias because the use of this medicine may cause hypertension, hypokalemia, and fluid retention as there is an increase in mineralocorticoid level which results from CYP17 inhibition.
Over Dose
Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.
Missed Dose
Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).
Storage and Disposal
Fast Tag
References