Zyceva 100mg Tablet

Brand Name Zyceva 100mg Tablet
Salt Composition Erlotinib (100mg)
Strength 100mg
Product Form Tablet
Storage Store at room temperature (10-30°C)
Category Anti Cancer
Country of Origin India
Manufacturer Natco Pharma Ltd
Manufacturer/Marketer AddressNatco Pharma Ltd,Natco House, Road No:2, Banjara Hills, Hyderabad, (A.P ) 500 033 India
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    Medical Description of Zyceva 100mg Tablet

    Zyceva 100mg Tablet contains Erlotinib. Erlotinib is a tyrosine kinase inhibitor. It acts as an epidermal growth factor receptor inhibitor and shrinks and stops the progression of abnormal cancer cells. Zyceva 100mg Tablet is used in the treatment of lung and pancreatic cancer. This medication is recommended only for adults.


    Zyceva 100mg Tablet Uses

    Zyceva 100mg Tablet is used in the treatment of non-small cell lung cancer and pancreatic cancer. It is used as an orphan drug for the treatment of malignant glioma. It is not used in children.


    Zyceva 100mg Tablet Benefits

    Zyceva 100mg Tablet is used in the treatment of non-small cell lung cancer that exhibits exon 19 deletions or exon 21 exon substitution. This tablet is used in the treatment of pancreatic cancer which is metastasised, locally advanced or unresectable. It is recommended only in adults.


    Zyceva 100mg Tablet Indication

    Zyceva 100mg Tablet inhibits the multiplication or proliferation of abnormal cells by inhibiting epidermal growth factors. Non-small cell lung cancer and pancreatic cancer can be treated with this tablet. This medication must be used only in adults.


    Mechanism of action of Zyceva 100mg Tablet

    Erlotinib is an antineoplastic and a tyrosine kinase inhibitor. The epidermal cells have surface growth receptors that has phosphotyrosine which is inhibited by Erlotinib thus the signalling process required for angiogenesis and proliferation of abnormal cells are inhibited. Erlotinib shrinks the abnormal cells and minimises metastasis thus treats and controls cancers or tumours.


    How Zyceva 100mg Tablet works

    Zyceva 100mg Tablet is an antineoplastic and tyrosine kinase inhibitor. It inhibits phosphotyrosine present in epithelial growth factor receptors thus the signalling process for angiogenesis and proliferation of abnormal cells is inhibited. Thus, the abnormal cells minimise the growth of abnormal cancer cells and terminate metastasis of tumours or cancers


    Zyceva 100mg Tablet Contraindication

    Absolute contraindication:

    • if you are allergic to Zyceva 100mg (Erlotinib 100mg) Tablet or its constituents
    • if you are pregnant
    • if you are breastfeeding
    • if you are lactose intolerant
    • if you are less than 18 years of age

    Relative contraindication:

    • if you have an interstitial lung disorder
    • if you have renal disorder
    • if you have a liver disorder
    • if you are diabetic


    Zyceva 100mg Tablet Side Effects

    Common side effects that occur 1:10 patients: Rash, Anorexia, Diarrhea, Fatigue, Nausea, Infection, Vomiting, Dyspnea, Stomatitis, Cough, Pruritus, Conjunctivitis, Dry skin, Keratoconjunctivitis sicca, Abdominal pain

    Uncommon side effects that occur 1:100 patients: Elevated LFT's, Acne, Paronychia, Weight loss, Pneumonitis pulmonary infiltrate, Pulmonary fibrosis

    Rare side effects that occur 1:1,000 patients: Interstitial lung disease-like events, rhabdomyolysis, uveitis


    FAQs for Zyceva 100mg Tablet

    Is Zyceva 100mg (Erlotinib 100mg) Tablet safe during pregnancy?

    No, taking Zyceva 100mg Tablet during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

    Can Zyceva 100mg Tablet be taken while breastfeeding?

    No, in general it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Zyceva 100mg Tablet can also pass via breastfeeding.

    Can Zyceva 100mg Tablet be taken while alcohol consumption?

    The interaction is unknown but Zyceva 100mg Tablet causes side effects. Thus, consult your physician.

    Can I take a drive or operate heavy machineries while on Zyceva 100mg Tablet?

    Zyceva 100mg Tablet causes side effects thus caution is used while driving or operating machineries.

    What is the best time to take Zyceva 100mg Tablet?

    You should take Zyceva 100mg Tablet on an empty stomach either 1 hr before food or 2 hrs after food intake.


    Precautions and general warning of Zyceva 100mg Tablet

    Alcohol

    Intake of Alcohol with Zyceva 100mg Tablet causes side effects thus caution is required. consult your physician

    Driving or operating machinery

    Driving or operating heavy machinery with Zyceva 100mg Tablet causes side effects thus caution is required. consult your physician

    Pregnancy

    Using Erlotinib during pregnancy may cause embryo-fetal toxicity. Consult your physician

    Breast Feeding

    Using Erlotinib during Breastfeeding may cause easy bruising and bleeding. Consult your physician

    Kidney Problem

    Using Erlotinib may lead to renal failure. During therapy monitor kidney function before and during treatment. Consult your physician

    Liver Disease

    During Erlotinib therapy monitor liver function before and during treatment.Consult your physician


    How to Take Zyceva 100mg Tablet

    This tablet is taken orally.

    This tablet must be taken at the same time once a day as prescribed by your physician.

    This tablet should be taken without food either 1 hr before food or 2 hrs after food intake

    This tablet must be swallowed as a whole.

    Don’t chew or crush this tablet.

    Don’t use antacids with this tablet.

    After therapy has been initiated, do not take more or less of Zyceva drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing Zyceva 100mg Tablet dose without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.


    Use of Zyceva 100mg Tablet in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.

    The recommended dosage in non-small cell lung cancer is 150mg taken orally once a day on empty stomach


    Use of Zyceva 100mg Tablet in children

    This tablet is not recommended in children.


    Use of Zyceva 100mg Tablet in Elderly Patients

    This tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Allergic reactions - It can be mild hypersensitivity and angioedema to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Electrolyte imbalance – causes hypokalemia/ hypertension/ edema. monitor function before and during treatment
    • Lung disorder – interstitial lung disorder. Monitor function before and during treatment
    • Hepatotoxicity– monitor function before and during treatment
    • Renal toxicity – renal failure. Monitor function before and during treatment.
    • Gastrointestinal perforation
    • Cardiotoxicity – MI
    • Blood disorders – hemolytic anemia and thrombocytopenia
    • Ocular conditions – uveitis, corneal perforation
    • Bleeding disorder – easy bruising and bleeding
    • Pregnancy – causes embryo-fetal toxicity
    • Breastfeeding – causes side effects similar to adults
    • Alcohol intake or Driving or operating heavy machinery – Zyceva 100mg Tablet causes side effects thus caution is required. consult your physician


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have an electrolyte problem

    If you have a renal problem

    If you are pregnant or breastfeeding


    General instructions

    Zyceva 100mg Tablet is taken orally as prescribed dosage at a specific time regularly without food either 1 hr before food or 2 hrs after food intake to avoid adverse effects. This tablet is always taken with prednisolone.


    Drug Interaction of Zyceva 100mg Tablet

    Drug-Drug Interaction

    Serum concentration is decreased by Acetaminophen, Aluminium hydroxide, Calcium carbonate

    Serum concentration is increased by Allopurinol, Ciprofloxacin, folic acid

    Severity of adverse effects is increased by Obeticholic acid

    St. John's Wort

    Drug-Food Interaction

    Do not take grapes and grape juice while taking the tablet. To avoid diarrhoea, take small sips of sugar-free drinks or take small amounts of a meal or take spicy food with the tablet. This tablet should be taken either 1 hr before or 2 hrs after food, if doubts arise kindly refer to your physician. It generally causes side effects thus it is advised not to be taken with alcohol. It is preferred to drive or operate heavy machinery with caution.

    Drug-Disease Interaction

    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
    • Blood disorders – used with caution in hemophilia or anemia. Consult a physician before use.
    • Pancreases disorders – used with caution in pancreatitis. Consult a physician before use


    Over Dose

    Overdosage of this tablet has less literature thus Contact your physician.


    Missed Dose

    You can take the missed dosage if you notice within 12 hours. If it is more than 12 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 30°C


    Fast Tag

    Zyceva 100mg Tablet is an antiangiogenic antineoplastic medication

    Erlotinib is a tyrosine kinase inhibitor

    This tablet is used to control and treat non-small cell lung cancer and pancreatic cancer

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease or kidney disease or cardiac disorders.